Researchers have developed a new technique for creating
human embryonic stem cells by fusing adult somatic cells with embryonic stem cells.
But no one has yet succeeded in making
human embryonic stem cells by cloning.
This year, a team led by the Hebrew University of Jerusalem finally produced haploid
human embryonic stem cells by forcing unfertilized egg cells to divide.
Not exact matches
ESCR scientists are mounting a furious political assault against the lawsuit, currently back in Royce Lamberth's court urging that
human embryonic stem cell research continue to be funded
by the Feds, hoping to pressure the judge to see it their way.
This question has been the topic of considerable legal and social debate over the years since the Supreme Court's Roe v. Wade decision» debate that has only been intensified
by the recent controversies over
human embryonic stem cells and
human....
He decreed that the case brought
by researchers Drs James Sherley and Theresa Deisher, along with a number of Christian groups including the Christian Medical Association, should be heard; and ordered an injunction temporarily blocking federal funding allocated for
human -
embryonic -
stem -
cell research.
One of the best talks of this conference was given
by Dr. Renee Reijo Pera, Professor and Director of the Center for
Human Embryonic Stem Cell Research at Stanford University.
Faced with an often - hostile Congress, Obama enacted many of his signature policies
by executive order — from reversing restrictions on research with
human embryonic stem cells to helping communities prepare for climate change.
Geron was bigger and better funded than ACT, and it was the first company to be approved
by the US Food and Drug Administration (FDA) to test a therapy in
humans based on
embryonic stem (ES)
cells.
Oliver Brüstle, director of the Institute of Reconstructive Neurobiology at the University of Bonn, Germany, who had a patent on a method for generating neurons from
human embryonic stem cells rejected
by the court, called the ruling «the worst possible outcome», and «a disaster for Europe».
Researchers at Geron, meanwhile, had successfully derived neurons from
human embryonic stem cells and were pursuing research that would eventually look to repair the damage caused
by spinal - cord injuries, a possible use for
embryonic stem cells that was much touted at the time.
«We've figured out for the first time how to produce these
cells from
human embryonic stem cells literally
by the billions and billions,» Lanza says.
Some of the researchers at the centre will study the differentiation of
stem cells into other
cell types, one group
by using
human embryonic stem cell biology and another
by studying early embryo development.
Human embryonic stem cell (hESC) research had been backed
by federal funds for more than a decade, but a surprise August injunction
by a federal judge threw the field's future into question.
Then, a team led
by Robert Lanza, the chief scientific officer of Advanced
Cell Technology Inc. in Marlborough, Massachusetts, and his colleagues published the first results ever of a clinical trial using
human embryonic stem cells.
To see whether cancer
stem cell renewal involves a chain of events similar to that used
by embryonic stem cells, and whether the process was affected
by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two
human breast cancer
cell lines that responded to low oxygen
by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.
For the purpose of additional experiments, the researchers generated myocardial
cells from
embryonic stem cells and
human skin
cells, in collaboration with the lab headed
by Prof Dr Jürgen Hescheler at the University of Cologne.
Newcastle University and the NorthEast England
Stem Cell Institute are aware that the research paper «Derivation of
Human Sperm from
Embryonic Stem Cells»
by a group led
by Professor Karim Nayernia has been withdrawn from the academic journal
Stem Cells and Development.
The final guidelines on research with
human embryonic stem cells issued on Monday
by the National Institutes of Health set out criteria for determining which ES
cell lines can be used in federally funded experiments and give NIH discretion to approve old lines that don't meet stringent modern ethical requirements.
Lamberth granted a preliminary injunction on this research after hearing a petition from a group of advocates who argued that, contrary to the U.S. government's view, research on
embryonic stem cells does in fact destroy embryos — action that is prohibited
by legislation known as the «Dickey - Wicker Amendment» to the bill that funds the Department of Health and
Human Services.
But after learning that work
by South Korean scientist Woo Suk Hwang had been faked, the journal Science retracted Hwang's landmark papers from 2004 and 2005, which reported the first
human embryonic stem cells from cloned embryos.
Mouse
embryonic stem cells, reported in 1981
by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of
human disease.
The work was led
by Dan S. Kaufman, a hematologist, and James A. Thomson, the first scientist to grow
human embryonic stem cells in culture.
The ethics council finally issued its 20 - page report just before Christmas, voting in favor of allowing the import of
human embryonic stem cells, under certain conditions,
by a small majority of 15 to 9, paving the way for next week's final showdown.
The National Institutes of Health (NIH) pleased
stem cell watchers today
by announcing the names of 10 companies and research groups that have
human embryonic stem cells federally funded researchers can use.
«Though the degree to which
human embryonic stem cells possess this feature is not entirely clear,
by understanding how another complex organism's genome works we ultimately learn more about how our own genome works,» said Zhou.
Yesterday, the same day an appeals court questioned lawyers about the case, the government filed documents in a lower court arguing that the lawsuit brought
by two researchers who oppose
human embryonic stem cell (hESC) research should be thrown out.
Obama and Clinton both voted for the
Stem Cell Research Enhancement Act, which would have broadly extended federal funding to human embryonic stem cell lines but was vetoed by Bush in 2006 and 2
Stem Cell Research Enhancement Act, which would have broadly extended federal funding to human embryonic stem cell lines but was vetoed by Bush in 2006 and 2
Cell Research Enhancement Act, which would have broadly extended federal funding to
human embryonic stem cell lines but was vetoed by Bush in 2006 and 2
stem cell lines but was vetoed by Bush in 2006 and 2
cell lines but was vetoed
by Bush in 2006 and 2007.
Replacement tissue that avoids rejection
by a patient's immune system is a step closer to the clinic, as researchers have created
human embryonic stem cells carrying the DNA of specific adults.
University of Michigan, Ann Arbor,
stem cell researcher Sean Morrison, an outspoken proponent of allowing research on
human embryonic stem cells (hESCs) in the state, has been wooed to Texas
by its $ 3 billion state cancer research program.
Advocates for research with
human embryonic stem cells are worried
by the latest twist in the
cells» political story.
The long - awaited registry of
human embryonic stem cell lines approved
by the National Institutes of Health (NIH) went up on the Web this week.
Because embryos are not destroyed to create them, they have been hailed as a way out of the ethical dilemma posed
by human embryonic stem cells.
Since its inception, CIRM has sought to create a system from the ground up for funding research on
human embryonic stem cells to fill in the gaps left
by federal funding restrictions (ScienceNOW, 12 April).
Experiments conducted
by lead author Fatima Syed - Picard, Ph.D., also of Pitt's Department of Ophthalmology, and the team showed that
stem cells of the dental pulp, obtained from routine
human third molar, or wisdom tooth, extractions performed at Pitt's School of Dental Medicine, could be turned into corneal stromal
cells called keratocytes, which have the same
embryonic origin.
Until recently, such
cells could be produced only
by destroying
human embryos and harvesting
embryonic stem cells.
Human embryonic stem cells derived from affected embryos during a pre-implantation diagnostic (PGD), as well as the conversion of somatic
cells, such as skin fibroblasts, into induced pluripotent
stem cells by genetic manipulation, offer the unique opportunity to have access to a large spectrum of disease - specific
cell models.
Twenty - seven
human embryonic stem cell (hESC) lines are ethically derived and should be approved for use in research funded
by the US linkurl: National Institutes of Health; http://www.nih.gov/ (NIH), a committee advising the NIH director linkurl: recommended today (December 4).
Neuronal developmental gene and miRNA signatures induced
by histone deacetylase inhibitors in
human embryonic stem cells.
Lamba and colleagues recently demonstrated that
human embryonic stem cells could be directed to differentiate into photoreceptors and respond to a light stimulus as measured
by ERG in crx − / − mice (a model for Leber's congenital amaurosis)[5].
Human pluripotent
stem cells from two sources today, one physiological
embryonic stem cells «ES» from the embryo, and the other experimental
cells «iPS» induced pluripotency
by reprogramming genetic somatic
cells.
What Collins does not say, however, is that the new NIH guidelines also allow for federal funds to be used in studying new
human embryonic stem cell lines that are created (
by private entities, of course) beyond the 700 currently in existence.
by Paroma Basu Scientists grow critical nerve
cells MADISON, WI — January 31, 2005 — After years of trial and error, scientists have coaxed
human embryonic stem cells to become spinal motor neurons, critical nervous system pathways that relay messages from the brain to the rest of the body.
When transplanted to the subretinal space of mice lacking functional photoreceptors,
human embryonic stem cells directed toward a retinal lineage integrate into the outer nuclear layer, express photoreceptor markers, and restore a light response as determined
by the electroretinogram (ERG)[5].
It has recently been demonstrated that mouse and
human fibroblasts can be reprogrammed into an
embryonic stem cell - like state
by introducing combinations of four transcription factors.
[6] S.A. Kuznetsov, N. Cherman, P.G. Robey, «In vivo bone formation
by progeny of
human embryonic stem cells,» Stem Cells Dev, 20:269 − 87, 2
stem cells,» Stem Cells Dev, 20:269 − 87,
cells,»
Stem Cells Dev, 20:269 − 87, 2
Stem Cells Dev, 20:269 − 87,
Cells Dev, 20:269 − 87, 2010.
Now researchers led
by the Wellcome Trust - Medical Research Council Cambridge
Stem Cell Institute have managed to induce a ground state by rewiring the genetic circuitry in human embryonic stem (ES) cells and in adult cells that have been induced into a pluripotent st
Stem Cell Institute have managed to induce a ground state
by rewiring the genetic circuitry in
human embryonic stem (ES) cells and in adult cells that have been induced into a pluripotent st
stem (ES)
cells and in adult
cells that have been induced into a pluripotent state.
Scientists investigating the mechanisms of Down Syndrome (DS) have revealed the earliest developmental changes in
embryonic stem cells caused
by an extra copy of
human chromosome 21 — the aberrant inheritance of which results in the condition.
Familial Dysautonomia (FD)
Human Embryonic Stem Cell Derived PNS Neurons Reveal that Synaptic Vesicular and Neuronal Transport Genes Are Directly or Indirectly Affected
by IKBKAP Downregulation.
At present, there are no
embryonic stem -
cell treatments approved
by the US Food and Drug Administration, and most
human studies of such therapies have shown unremarkable results.