«The most important application of this patent will be the use of our patented
human endoderm cells to screen for agents that potentially affect endoderm differentiation, for example, to any of the important cells derived from endoderm such as lung, liver, intestine, pancreas, thymus, parathyroid and thyroid.»
U.S. Patent No. 7,510,876, issued on March 31, 2009 is directed to an in vitro
human endoderm composition.
Not exact matches
But we do know that, like other animals, the
human embryo in its earliest stages consists of three main components known as germ layers: the ectoderm, the
endoderm and the mesoderm.
Pancreatic
endoderm derived from
human embryonic stem cells generates glucose - responsive insulin - secreting cells in vivo.
Initial imaging analysis of fluorescently labelled
human iPSC - derived hepatic
endoderm cells, umbilical cord - derived endothelial cells (HUVECs), and mesenchymal stem cells (MSCs) co-cultured in a solidified matrix gel to promote 3D growth found that the different cells collectively and automatically «condensed» into a multicellular central unit.
San Diego, CA (June 3, 2009)-- Novocell, Inc., a stem cell engineering company, today announced that it has received U.S. Patent No. 7,541,185 with method claims covering the use of
endoderm cells derived from
human embryonic stem cells (hESCs) for drug discovery.
Rational Bioprocess Design for
Human Pluripotent Stem Cell Expansion and
Endoderm Differentiation Based on Cellular Dynamics.
ViaCyte's patent portfolio covers many of the intermediary cell types generated when
human pluripotent stem cells progress along the differentiation pathway to pancreatic progenitor cells, including mesendoderm and definitive
endoderm.
On the other hand, ES cells and cells differentiating into
endoderm and mesoderm lineages from ES cells express OCT - 4 in mice and
humans [66], and SSEA1 expression is found in other type of cells including neural stem cells and mesenchymal stem cells [67], [68].
In November 2014, BioPharma-Reporter.com reported that ViaCyte won a U.S. patent to manufacture
human pancreatic progenitor cells from
endoderm (embryonic stem) cells.
«This settlement resolves the parties» various patent disputes worldwide with respect to
human definitive
endoderm cells from
human pluripotent stem cells.
Differentiation into extraembryonic
endoderm [21] or neural progenitors [33] are frequent early outcomes of spontaneous differentiation when
human ES cells are cultured in the presence of a feeder cell layer, and it is interesting to speculate that the cells are being primed for these fates.
San Diego, CA (March 31, 2009)-- Novocell, Inc., a stem cell engineering company, today announced that it has received U.S. Patent 7,510,876 with claims covering
human definitive
endoderm cells, an essential cell for generating not only pancreatic type cells, which Novocell is developing for use as a cell therapy for diabetes, but also other
endoderm lineage - derived tissues and organs such as lungs, intestine, liver, thymus and thyroid.