Q: In Darwin's Radio, you wrote about the evolution of a new human species that is triggered by an HERV, or
Human Endogenous Retrovirus — which, if I understand correctly, is a kind of ancient virus that has entered into human DNA and persisted there in a dormant state for hundreds of thousands, if not millions, of years.
The more powerful one occurred within a stretch of DNA, or locus, that contains the HCP5 gene, which codes for
a human endogenous retrovirus — a genetic fossil of a virus that wove itself into human chromosomes long ago but no longer produces infectious progeny.
Our DNA carries dozens of copies of Perron's virus, now called
human endogenous retrovirus W, or HERV - W, at specific addresses on chromosomes 6 and 7.
The virus, called
human endogenous retrovirus W (HERV - W), codes for a protein that, when activated, sets off an inflammatory cascade in the brain that leads to symptoms.
Of individuals with recent - onset schizophrenia, 29 % exhibited signs of a particular family of retroviruses known as
Human Endogenous Retrovirus W (HERV - W), compared with none of the control patients.
Some of the first genes to start expressing themselves again are former viruses turned into transposable elements known as
human endogenous retroviruses, particularly one called HERVK, Wysocka and colleagues found.
Called
human endogenous retroviruses (HERVs), the vast majority of these ancient viruses are no longer functional.
Not exact matches
Vestigial features, study of ebryonic development, biogeography, DNA sequencing, examining pseudogenes, study of
endogenous retroviruses, labratory direct examination of natural selection in action in E-Coli bacteria, lactose intolerance in
humans, the peppered moth's colour change in reaction to industrial pollution, radiotrophic fungi at Chernobyl all add to the modern evolutionary synthesis.
Tangible proof can be found by studying vestigial features, ebryonic development, biogeography, DNA sequencing, pseudogenes,
endogenous retroviruses, labratory direct examination of natural selection in action in E-Coli bacteria, lactose intolerance in
humans, the peppered moth's colour change in reaction to industrial pollution, radiotrophic fungi at Chernobyl... all of these things add to the modern evolutionary synthesis.
Evolutionary theory has been validated in the successful prediction of a wide range of biological observations, e.g., the fused 2nd
human chromosome, the phylogenetic distribution of
endogenous retroviruses, the relative positions and features of intermediate and transitional fossils, etc, etc..
Now a team led by Robin Weiss of London's Institute of Cancer Research reports that the «PK» porcine
endogenous retrovirus, which does not appear to harm pigs, can replicate in mink and
human cells.
And in lab experiments, these porcine
endogenous retroviruses (PERVs) tended to leap from pig to
human cells.
But such genetic intrusions stick around a very long time, so
humans are chockablock full of these embedded, or
endogenous,
retroviruses.
We are conducting a systematic survey to monitor genome stability, including transcriptional activation of
endogenous retroviruses (ERVs) in the
human genome following iPS reprogramming and differentiation.
In 2011, Paprotka, et al. reported that XMRV likely originated through recombination between 2
endogenous murine
retroviruses, PreXMRV - 1 and PreXMRV - 2, during in vivo passaging of the
human prostate cancer xenograft CWR - R1, resulting in establishment of the XMRV - infected 22Rv1 cell line [38].