Not exact matches
So Daniel Anderson at the Massachusetts Institute of Technology exposed
human bone marrow stem
cells to biodegradable nanoparticles carrying the
human gene for vascular
endothelial growth factor (VEGF),
which attracts blood vessels to injury sites.
The protein, they found, preferentially binds to
human endothelial cells, allowing the retrovirus,
which would not normally infect
human cells, to enter them.
In experiments conducted on
human lung
endothelial cells and in mice, the researchers showed that NS1 caused permeability of the endothelium,
which lines the walls of blood and lymph vessels.
Malinski's team has developed unique methods and systems of measurements using nanosensors,
which are about 1,000 times smaller in diameter than a
human hair, to track the impacts of Vitamin D3 on single
endothelial cells, a vital regulatory component of the cardiovascular system.
The epithelium's maturation into a villus intestinal epithelium with long finger - like extensions was helped along by co-culturing
human intestinal microvascular
endothelial cells on the opposite side of the shared matrix - coated porous membrane in the «vascular» channel where they assembled a surrogate blood vessel with a hollow lumen through
which feeding medium was flowed.
In an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in
which cells from a
human intestinal
cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from
human blood vessel - derived
endothelial cells in the adjacent channel.
To study this barrier and determine why a lack of blood flow causes it to leak, the researchers built a blood - vessel - on - a-chip model consisting of a channel lined with a layer of
human endothelial cells surrounded by extracellular matrix within a microfluidic device,
which allowed them to easily simulate and control the flow of blood through a vessel and evaluate the
cells» responses.
The present demonstration of T
cell - mediated apoptosis of allogeneic corneal
cells from CD4 KO mice is consistent with previous findings,
which noted the presence of apoptotic keratocytes and corneal
endothelial cells in rejected corneal allografts in
humans and rats respectively (5, 32).
A team led by Young - sup Yoon, MD, PhD developed a new method for generating
endothelial cells,
which make up the lining of blood vessels, from
human induced pluripotent stem
cells..
Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after
which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study,
human coronary artery
endothelial cells were exposed to the smoke equivalent to one cigarette,
which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart
cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain
cells.96