Sentences with phrase «human fibroblasts into»

W. Hu et al., «Direct conversion of normal and Alzheimer's disease human fibroblasts into neuronal cells by small molecules,» Cell Stem Cell, doi: 10.1016 / j.stem.2015.07.006, 2015.

Oct4, Sox2, c - Myc, and Klf4 were the four original factors that were capable of converting mouse and human fibroblasts into iPs cells [1], [3], [5], [11], [12].

Not exact matches

Researchers used the CRISPR / Cas9 gene editing technique to introduce a segment of a human gene causing Huntington's, with a very long glutamine repeat region, into pig fibroblast cells.

For the new study, the team used a cell - reprogramming technique (similar to those used to reprogram skin cells into stem cells) to generate human DRG - type sensory neurons from ordinary skin cells called fibroblasts.

Human embryonic stem cells derived from affected embryos during a pre-implantation diagnostic (PGD), as well as the conversion of somatic cells, such as skin fibroblasts, into induced pluripotent stem cells by genetic manipulation, offer the unique opportunity to have access to a large spectrum of disease - specific cell models.

It has recently been demonstrated that mouse and human fibroblasts can be reprogrammed into an embryonic stem cell - like state by introducing combinations of four transcription factors.

Nectin - 1 / HveC mediates herpes simplex virus type - 1 entry into primary human sensory neurons and fibroblasts.

They have already shown that they can transform human fibroblast cells into pluripotent stem cells, and now plan to start working on delivering the proteins needed to differentiate stem cells into specialized tissues.

His research is focused on retinal regeneration by reprogramming human fibroblasts either into induced pluripotent stem cells or directly into photoreceptors.

The researchers then successfully prodded what they call keratinocyte - derived iPS cells or KiPS cells to distinguish them from fibroblast - derived iPS cells into becoming all the cell types in the human body, including heart muscle cells and dopamine - producing neurons, which are affected by Parkinson's disease.

«When we injected GMT into each of the three types of human fibroblasts, nothing happened — they never transformed — so we went back to the drawing board to look for additional genes that would help initiate the transformation,» said Gladstone Staff Scientist Ji - dong Fu, PhD, the study's lead author.

«Our findings here serve as a proof of concept that human fibroblasts can be reprogrammed successfully into beating heart cells.»

The research team began by injecting all candidate genes into the human fibroblasts.