The relationship between stromal cell derived SPARC
in human gastric cancer tissue and its clinicopathologic significance.
«Our data, combining computational, experimental assays, and analyses
of human gastric cancers, indicates that the use of these less immunogenic variants may enhance the ability of a tumour to bypass the host's immune system.
Here, we tested
whether human gastric cancers, which are among the most aggressive tumor entities, express the cellular receptor of Shiga toxin, the glycosphingolipid globotriaosylceramide (Gb3 / CD77).
Moreover, the C - terminal region of LARP7, which is essential for the sequestration of P - TEFb in 7SK snRNP, is required for LARP7's suppression of breast cancer survival and is frequently deleted in
human gastric cancer (Mori et al., 2002), suggesting that LARP7 may be a potential tumor suppressor in a broad range of human carcinomas.