They have made possible wholesale scans that turn up new gene modifications and variations, and the same should prove true for the new
human gene arrays, says Joseph Ecker, a plant scientist at the Salk Institute for Biological Studies in La Jolla, California, who has helped pioneer whole - genome chips for Arabidopsis.
Not exact matches
On the contrary, he finds it useful to ponder an
array of reductionist attempts to explain the existence of religion, from that which seeks to pinpoint the area of the
human brain or the specific
genes connected to religiosity to that which sees religion as a malfunction of the
human mind or a vestigial remnant from a primitive stage of
human development suitable only for whimpering, immature dullards (a point of view championed by the new atheists).
The Duke researchers who made this discovery say it may help explain how a relatively small number of
genes can create the dazzling
array of different cell types found in
human brains and the nervous systems in other animals.
For his part, Collins, who has led NIH since 2009 and been kept on by the Trump administration, pointed to an
array of promising NIH activities, including the development of new technologies to provide insights into
human brain circuitry and function through the Brain Research through Advancing Innovative Neuroethologies (BRAIN initiative) and the use of the
gene - editing tool CRISPR - Cas9 to correct mutations and clear the way to develop and test a «curative therapy» for the first molecular disease: sickle cell disease.
Two recent studies — one in mice and another in
humans — provide new evidence that a mind - numbingly complex
array of
genes influence body weight.
He identified dozens of
genes staph had snatched from a wide
array of organisms, ranging from fellow bacteria to
humans.
The company now has an
array of fully
human antibodies in its pipeline created with its proprietary VelocImmune mouse, which has been engineered to express
human antibody
genes while still mounting a robust immune response by making antibodies with fully
human variable regions and mouse constant regions.
mRNA expression was analyzed in adipose tissue from discordant twins using GeneChip
Human Gene 1.0 ST
arrays (Affymetrix, Santa Clara, CA) according to the manufacturer's recommendations.
Array CGH provided a much better look at the
gene content on the chromosomes of
human embryonic stem cells, with a resolution about 100 times better than standard clinical methods.
Using novel
gene -
array technology to measure the extent of
gene expression in thousands of
genes simultaneously, this study shows that as
humans diverged from their ape ancestors in the last five million years,
genes for transcription factors — which control the expression of other
genes — were four times as likely to have changed their own expression patterns as the
genes they regulate.
For custom
gene expression projects the Genomics Core has a platform that uses sets of
human and mouse custom
arrays whose probe content is aimed at
gene expression studies in the areas of cancer, immunology and other complex diseases.
Gene expression profiles measured using
human genome Affymetrix
Gene Chip
arrays were grouped by hierarchical clustering, and correlation coefficients were computed for all pair-wise comparisons (Fig. 4A).
Human cancers exhibit a diverse
array of genomic gains and losses that alter the dosage of hundreds of
genes at once.
«For DNA
arrays involving
human genes, we're talking about analyzing 18,000 segments of DNA,» he said.
By analyzing genome sequence data from
human populations, including 1269 individuals from sub-Saharan Africa, we identify a diverse
array of large copy number variants affecting the host invasion receptor
genes GYPA and GYPB We find that a nearby association with severe malaria is explained by a complex structural rearrangement involving the loss of GYPB and gain of two GYPB - A hybrid
genes, which encode a serologically distinct blood group antigen known as Dantu.
The
human microbiome — the diverse
array of bacteria, yeast, parasites, and other single - celled organisms that live in and on our bodies — is comprised of more microbes than there are stars in the galaxy, and the
genes encoded in microbiome DNA vastly outnumber our own
genes.