Sentences with phrase «human gene data»

Not exact matches

Katherine High, Spark's president and chief scientific officer, expressed her enthusiasm for the early clinical data related to SPK - 8011: «The encouraging start of our SPK - 8011 clinical trial reinforces the strength of our gene therapy platform, delivers human proof - of - concept in a second liver - mediated disease — a significant achievement in the gene therapy field — and positions us well to potentially transform the current treatment approach for this life - altering disease with a one - time intervention.»

The data suggest that around 3500 B.C. — roughly the same time that many linguists place the origin of PIE and that archaeologists date horse domestication — Yamnaya genes replaced about 75 percent of the existing human gene pool in Europe.

An apparently new Variant of human serum albumin, albumin Naskapi, has been found in high frequency in the Naskapi Indians of Quebec and, in lower frequency, in other North American Indians.The family and population data of the albumin are consistent with its inheritance as a simple autosomal trait Controlled by a gene designated Al Naskapi.

Data published by the International Human Genome Sequencing Consortium indicate that somewhere between 113 and 223 genes present in bacteria and in the human genome are absent in well - studied organisms — such as the yeast Saccharomyces cerevisiae, the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans — that lie in between those two evolutionary extrHuman Genome Sequencing Consortium indicate that somewhere between 113 and 223 genes present in bacteria and in the human genome are absent in well - studied organisms — such as the yeast Saccharomyces cerevisiae, the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans — that lie in between those two evolutionary extrhuman genome are absent in well - studied organisms — such as the yeast Saccharomyces cerevisiae, the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans — that lie in between those two evolutionary extremes.

Our data demonstrate the feasibility of targeted gene disruption in multiple rat strains within 4 months time, paving the way to a humanized monoclonal antibody platform and additional human disease models.

Data - heavy phenomena like gene regulation may be too complicated for human scientists to pin down.

In a new study published in The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cooking.

«We used the Allen Human Brain Atlas data to quantify how consistent the patterns of expression for various genes are across human brains, and to determine the importance of the most consistent and reproducible genes for brain function.&rHuman Brain Atlas data to quantify how consistent the patterns of expression for various genes are across human brains, and to determine the importance of the most consistent and reproducible genes for brain function.&rhuman brains, and to determine the importance of the most consistent and reproducible genes for brain function.»

«It is exciting to find a correlation between brain circuitry and gene expression by combining high quality data from these two large - scale projects,» says David Van Essen, Ph.D., professor at Washington University in St. Louis and a leader of the Human Connectome Project.

«Those modern humans» selected genes under selection may prove central to a relevant process of domestication, given that these interactions may provide significant data on relevant phenotypic traits,» said Boeckx.

The scientists» analyses detected antibiotic resistance gene determinants in all 71 environments represented in the public data, including soil, oceans, and human feces.

ET: «What this data analysis pipeline, moreover, creates is motivation to look for similar forms of gene loss in other types of symbioses, such as that between humans and their gut microbiomes.

... Accessing systems... cataloging human genomic data... compiling... analyzing... detecting essential genes... learning... modeling... accessing literature... tracking pathogens... outbreaks... viral interactions... RNAi... CRISPR... learning... modeling... analyzing social networks... crypto mining... ordering synthetic biopolymers... sending... waiting...

Their analysis — which used DNA data from a Neandertal woman from the Altai Mountains in Siberia (SN: 1/25/14, p. 17) and 112,338 present - day British people — confirmed some links between Neandertal heritage and human diseases made by previous studies (SN: 3/5/16, p. 18), but didn't find evidence that Neandertal gene variants contribute to obesity.

They show that about 92 per cent of the population harbors bacteria with a variant of the gene sequence, according to a survey of public genome data from 250 adult humans.

The first stumbling block was obtaining enough data to work out how often human genes are inherited together in families.

Andrechek's federally funded study looked at mice containing all subtypes and compared the makeup of the rodent tumors and the way the genes acted, known as gene expression, to human tumor data.

The measurement data prove that the feature is inherited in a similar way in all primates — humans included — and varies across different species and genera in a way that mirrors the evolutionary relationships worked out earlier by analyzing bones and comparing genes.

In a Cell paper published on April 7, Lanner's team analysed gene expression in 88 early human embryos and is using those data to identify genes to disrupt in embryos using CRISPR — Cas9.

HDNetDB allows users to obtain, visualise and prioritise molecular interaction networks using Huntington's disease - related gene expression and other types of data obtained from human samples and other sources.

If, say, an unexpected adverse event pops up in a human trial, the informaticians can then sift animal, lab, and human data to investigate the possibility that certain gene variants or other factors predispose patients to the adverse event.

When Peter Parham's postdoc first showed him data suggesting a gene in some wild chimpanzees infected with the AIDS virus closely resembled one that protects humans from HIV, he was skeptical.

They entered the sequence of the gene that encoded the transporters in a genome data bank and saw that it closely matched the genes for Rh proteins in humans.

In today's issue of Science Translational Medicine, he and his colleagues present a more efficient way of finding such new uses for old drugs: by bringing together data on how diseases and drugs affect the activity of the roughly 30,000 genes in a human cell.

I'm not liking what I'm hearing, I tell Mattingly with a nervous laugh, but she reiterates that the data on human toxicity and the impact of pollutants on genes remain sketchy.

Our data provide proof that siRNAs can be delivered to human liver and therein modulate gene expression through RNAi.

Bethesda, Md., Thurs., Sept. 29, 2011 — Over the next five years, National Institutes of Health (NIH)- funded researchers will extensively test and generate data about mice with disrupted genes to gain clues about human diseases.

A mile - stone has been achieved with data for 75 % of the human protein - coding genes and protein evidence for all human genes predicted from the genome sequence.

The Human Protein Atlas has reached a major milestone by releasing protein data for more than 80 % of the human protein - coding genes and RNA expression data for more than 90 % of the gHuman Protein Atlas has reached a major milestone by releasing protein data for more than 80 % of the human protein - coding genes and RNA expression data for more than 90 % of the ghuman protein - coding genes and RNA expression data for more than 90 % of the genes.

«This data allows classification of all human protein - coding genes into those coding for house - hold functions (present in all cells) and those that are tissue - specific genes with highly specialized expression in particular organs and tissues, such as kidney, liver, brain, heart, pancreas.

ENSEMBL makes available substantial and diverse transcript information, including the CCDS [13, 41], Human and Vertebrate Analysis and Annotation (HAVANA)[42], Vertebrate Genome Annotation (Vega)[43], ENCODE data [12] and the GENCODE gene and transcript sets [15].

«We are truly excited about the RNA transcript data and the map of gene expression that we now have for 27 different organ - specific tissues», says Professor Mathias Uhlén, Program Director of the Human Protein Atlas.

The gene - centric visualization with data covering a majority of the human protein - coding genes is now complemented with RNA transcript data.

These knockout mice, together with the wealth of associated data, will serve as a valuable, freely available, resource for French researchers investigating gene function and human pathophysiology.

This is a great example of a potential gene therapy target that still needs a fair amount of work to validate the thesis and the initial data, but having a large number of existing human carriers is a good sign on the safety front.

Those genes were also found in a large data set of mice who had gone through the same types of experiments, which gave the team hope that they'd be in anxious humans, too.

With the reference cell census data in hand, the research team is excited to conduct additional studies, including ones involving models or human patients with gastrointestinal conditions — Crohn's disease, ulcerative colitis, gastrointestinal cancers, forms of food allergy, etc. — aimed at identifying changes in gene expression and epithelial structure and function that could reveal new insights and opportunities for therapeutic development.

Improving human health by enabling safer, more effective cell and gene medicines through proprietary genomics, bioinformatics and intelligent data driven design

The challenge for the years to come is to convert data on new genes, gene defects and human genome variation in patients with genetic cardiovascular disease into functionally relevant information on the diverse pathophysiological mechanisms and clinical manifestations.

We focus on developing computational methods and tools for (a) analyzing large - scale gene expression data related to human cancer in search for gene markers and disease sub-categories, (b) identifying regulatory elements such as miRNA precursors and their targets in whole genomes of plants and mammals, (c) building theoretical models of gene regulatory networks.

He has helped generate and interpret mountains of data through microbial gene sequencing efforts, showing how microbes influence human well - being.

The new data — from animals and human cells — show that the vapors released by e-cigarettes can alter the activity of genes.

In worms, flies, mice and human, there are insufficient data as yet to determine what proportion of genes are duplication products.

The September 2012 release includes data corresponding to 14,079 human genes (approx. 70 % of the total genome).

The normalized Tags Per Million for each gene were calculated and subsequently used to categorize the genes using the same classification as described above and using Tags Per Million ≥ 1 as threshold for detection to allow for comparisons with the Human Protein Atlas data.

To build upon the encouraging early discoveries, Helmsley renewed and expanded its Crohn's funding for the Institute in 2013 to begin new work with three major aims: 1) continue studies of individual genes to determine how genetic differences between Crohn's patients and healthy individuals contribute to the disease; 2) evaluate promising small molecules in disease - relevant studies and prioritize insights from genetics to help develop novel therapeutics; and 3) begin basic experimentation in animal models with Crohn's disease to provide the data necessary to begin testing new therapies in humans.

Test each mutant mouse line (4,000 mouse lines in the first 5 years, and ultimately up to 20,000) through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human diseases.Through this activity and employing data annotation tools, systematically aim to discover and ascribe biological function to each gene, driving new ideas and underpinning future research into biological systems.

While the data answer many questions about such issues as Neanderthal language capacity and the genes they passed onto humans through interbreeding, we're still a long way from being able to resurrect one.

The quality and novelty of the data, leads to new insights into the replication landscape of the human genome and to further unravel the links between replication, gene expression, epigenetic modification and 3D genome organization in normal and cancer cells.

The aim of his research was to use microarray gene expression data in order to characterize ageing in different human tissues and identify the age at which major changes in genetic expression profiles occur.