Sentences with phrase «human gene maps»

Buffeted by the shifting winds of human genome research, government officials have decided to close an 8 - year - old collection of human gene maps maintained by Johns Hopkins University.

Not exact matches

Then, given your clearly profound understanding of the relevant science, you can explain how humans came to possess a defunct gene for egg - yolk proteins in our placental mammal genomes and why the presence of this dead gene and the mutations rendering it defunct map to the lineages observable in the fossil record?

Billions of dollars and thousands of scientists are devoted to producing an exhaustive map of the chromosome structure that contains the DNA comprising the genes of human beings.

The most compelling comes from the study of genes, especially now that the Human Genome Project has been completed and the genomes of many other species being constantly mapped.

2) As to Neanderthal they did not have the brain capacity (Steve Olson, Mapping Human History: Genes, Race, and Our Common Origins (New York: Houghton Mifflin Co., 2002), to wonder, thus not the first Adam 3) Nicodemus went to Jesus in the dark of night and Jesus said «I have spoken to you of earthly things and you do not believe so how can you believe when I speak of heavenly things».

She has also been able to map the process of human embryos expressing their genes.

Erwin compares the endeavor to the Human Genome Project, in which scientists mapped the sequence of our genes.

A screen for mouse genes dependent on dHAND, a transcription factor implicated in neural crest development, identified Ufd1, which maps to human 22q11 and encodes a protein involved in degradation of ubiquitinated proteins.

The map is a key tool that geneticists rely on to find disease genes and identify the functional genetic variations at the core of human diversity.

For the first time, a research team led by Dr. Ralf Gilsbach and Prof. Dr. Lutz Hein from the Institute of Experimental and Clinical Pharmacology and Toxicology at the University of Freiburg have mapped out the gene regulators in the DNA of human cardiac muscle cells.

The new research focused on just nine genes, those most strongly associated with autism in recent sequencing studies, and investigated their effects using precise maps of gene expression during human brain development.

The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response of breast and ovarian tumor cells to common classes of chemotherapy treatment.

«We couldn't have done this even two years ago,» State said, «because we didn't have the key ingredients: a set of unbiased autism genes that we have confidence in, and a map of the landscape of the developing human brain.

From there, we can map these genes in humans.

Alongside its soon - to - be — unveiled physical map, CEPH - Genethon is also leading the world with its efforts to build human «genetic maps» — maps which show the relative positions of thousands of genes, culled from careful genealogical work on the way characteristics are passed on in human families.

To find and clone a human gene of unknown function, researchers begin with a genetic map.

First maps of gene expression in Neanderthals and Denisovans could explain why they looked different from us — and why autism may be unique to humans

When scientists first started mapping human genomes and comparing them to other organisms, they were shocked to discover humans don't have that many more genes than flies do.

The Allen Institute for Brain Science in Seattle, Washington, US, is today launching a four - year, $ 55 - million effort to build a three - dimensional map documenting the levels of activity of some 20,000 different genes across the human brain.

By the time the DNA sequencer made the Human Genome Project possible in the late 1990s, scientists were mapping genes at thousands of times the rate that they had done two decades before.

Hubbard does not dispute this: what concerns her, rather, is that the intensified effort to «map» the human genome puts too much emphasis on genes and too little on the contexts in which they work — or in which people work.

Geneticists speak of «mapping» the human genome, so that we know where genes «for» all kinds of things (from homosexuality to manic depression) are located; a promotional video produced by the Human Genome Project asks viewers to «imagine a map that would lead us to the richest treasure in the world», with which we will know «where... every genetic inheritance of humankind is to be found&rahuman genome, so that we know where genes «for» all kinds of things (from homosexuality to manic depression) are located; a promotional video produced by the Human Genome Project asks viewers to «imagine a map that would lead us to the richest treasure in the world», with which we will know «where... every genetic inheritance of humankind is to be found&raHuman Genome Project asks viewers to «imagine a map that would lead us to the richest treasure in the world», with which we will know «where... every genetic inheritance of humankind is to be found».

This approach has contributed to the successful mapping of genes involved in numerous human diseases such as Huntington's disease and cystic fibrosis, an important first step in understanding these conditions.

The Allen Spinal Cord Atlas, which will be available online for free in early 2009, will map out which genes are active in which locations along the spine in mice, which share 90 percent of their genetic material with humans.

Freiburg researchers map out the atlas of gene regulators in human cardiac cells for the first time

For example, many studies on human microbiota identify species (or operational taxonomic units) and map evolutionary relationships using the 16S ribosomal RNA gene.

In their comprehensive study, which involved a search of gene activity maps as well as testing of human brain tissue, the researchers identified more than 100 enhancers which were much more active in the brain than in other tissues.

For instance, the Human Microbiome Project (HMP)(Turnbaugh et al, 2007; Peterson et al, 2009; Huttenhower et al, 2012) and MetaHIT (Qin et al, 2010) have generated maps of bacterial species abundances throughout the human body, reference genomes, and catalogs of more than 100 million microbial genes assembled from shotgun sequencing of in vivo communiHuman Microbiome Project (HMP)(Turnbaugh et al, 2007; Peterson et al, 2009; Huttenhower et al, 2012) and MetaHIT (Qin et al, 2010) have generated maps of bacterial species abundances throughout the human body, reference genomes, and catalogs of more than 100 million microbial genes assembled from shotgun sequencing of in vivo communihuman body, reference genomes, and catalogs of more than 100 million microbial genes assembled from shotgun sequencing of in vivo communities.

For their seminal contributions to concepts and methods of creating a genetic map in the human, and of positional cloning, leading to the identification of thousands of human disease genes and ushering in the era of human genetics.

These efforts include theAllen Brain Atlas, which has spatially mapped gene expression across the human brain, and the NIH» sBRAIN Initiative, which is accelerating the development and application of new technologies.

«We are truly excited about the RNA transcript data and the map of gene expression that we now have for 27 different organ - specific tissues», says Professor Mathias Uhlén, Program Director of the Human Protein Atlas.

The 2013 Warren Alpert Foundation Prize will be awarded to David Botstein of Princeton University, and Ronald W. Davis and David S. Hogness, of Stanford University School of Medicine, for their seminal contributions to the concepts and methods of creating a genetic map in the human, leading to the identification of thousands of disease genes.

Botstein and Davis» landmark conceptual breakthrough, published in 1980, gave researchers the tools to trace and map out the genetic inheritance of disease in humans, while Hogness» work provided the means of identifying the precise physical location of genes of interest on chromosomes.

The researchers identified the human gata5 gene and mapped it to chromosome 20 as a first step towards identifying human mutations.

The current SNP map now makes it possible for genome - wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.

The ENCODE maps allow researchers to inspect the chromosomes, genes, functional elements and individual nucleotides in the human genome in much the same way.»

An international team of scientists led from Sweden's Karolinska Institutet / SciLifeLab has for the first time mapped all the genes that are activated in the first few days of a fertilized human egg.

«In addition to our gene - mapping efforts, we try to provide diagnostic expertise for doctors and patients, since the surprising diversity of genetic disorders of human cortical development is only beginning to be appreciated.»

In 1997, when few genome sequences were available, Hieter helped create XREFdb, a public database that linked the functional annotations of genes studied in model organisms with the phenotypic annotations on the human and mouse genetic maps.

Previous honorees include David Botstein of Princeton University and Ronald W. Davis and David S. Hogness of Stanford University School of Medicine for their seminal contributions to the concepts and methods of creating a human genetic map, leading to the identification of thousands of disease genes; Julian Adams of Infinity Pharmaceuticals, Alfred Goldberg of Harvard Medical School and Kenneth Anderson and Paul Richardson, both of Dana - Farber Cancer Institute, for the development of bortezomib, a drug that has altered the lives of hundreds of thousands of people with multiple myeloma; Alain Carpentier of Hôpital Européen Georges Pompidou in Paris and Robert S. Langer of MIT for innovations in bioengineering.

(G) Heat map derived from quantitative RT - PCR depicting relative expression of multiple genes associated with pluripotency comparing human MSCs, NSCs, and ESCs.

All human genes have been mapped to representative PDB structure protein chains (selected from sequence clusters at 40 % sequence identity) to show which regions of a gene are available in PDB coordinates.

The map evaluated mutations in virtually all known human protein - encoding genes, comprised of more than 20,000 genes, in 24 pancreatic cancers and 22 brain cancers.

A paper describing the discovery, entitled «A major susceptibility gene for asthma maps to chromosome 14q24,» has been published in the online edition of the American Journal of Human Genetics at www.ajhg.org.

In 2001, it took 15 months and 300 million dollars to map the 20,000 genes in the human genome.

The gene was mapped to a small region on chromosome 18, which previous studies have suggested may play a role in blood pressure regulation in humans, mice and rats.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

A Susceptibility Gene for Psoriatic Arthritis Maps to Chromosome 16q: Evidence for Imprinting American Journal of Human Genetics 2003 Jan; 72 (1): 125 - 31.

Mutations that allow human Ad2 and Ad5 to express late genes in monkey cells map in the viral gene encoding the 72K DNA binding protein

mRNA levels of the CYP4F gene cluster were quantified in human liver samples (n = 149) obtained from a well - characterized liver bank and fine mapping of the CYP4F gene cluster encompassing CYP4F2, CYP4F11, and CYP4F12 was performed.