Sentences with phrase «human gene regulation»

«This paper lifts the lid off something that had been largely unsuspected: the tremendous species - specific dimension of human gene regulation,» says Trono.

Not exact matches

For 50 years, the fundamental principles and mechanisms of the epigenetic regulation of gene expression have been explored across myriad organisms and human diseases.

«The reversible nature of the m6A methylmark adds a new layer to the regulation of gene expression now termed «epitranscriptomics» and warrants further research to establish links with human disease such as cancer,» adds Dr Irmgard Haussmann of Coventry University.

Data - heavy phenomena like gene regulation may be too complicated for human scientists to pin down.

Cavalli and his team at the Institute of Human Genetics (University of Montpellier / CNRS) are the first to show that regulation of gene position can lead to transgenerational inheritance.

Now researchers have identified a mutation in the human ATP4a gene that is involved in the gastric acid secretion regulation and has been identified as responsible of an aggressive form of inherited, early - onset gastric NET.

The protein studied in the mold is part of a larger family of proteins also found in humans and involved in many essential biological processes including gene regulation and fatty acid metabolism.

«We set out to find out about human genes that are implicated in the regulation of the gut microbiome, and we found some that are,» says senior author Ruth Ley, an Associate Professor in the Department of Microbiology at Cornell University and the study's senior author.

An international consortium of researchers in the Genotype - Tissue Expression (GTEx) Consortium published findings about how genetic variation effects gene regulation in 44 human tissue types.

Xu applied the DNA microarray technique to screen more than 100,000 genes in the human genome to find the exact gene regulation pathway.

Building on years of mouse and gene regulation studies, they have developed a resource that can help scientists better understand how similarities and differences between mice and humans are written in their genomes.

«In general, the gene regulation machinery and networks are conserved in mouse and human, but the details differ quite a bit,» noted co-senior author Michael Snyder, Ph.D., director, Stanford Center for Genomics and Personalized Medicine, Stanford University, Stanford, California.

In Britain, the regulations governing genetically modified organisms came into force in 1992, before the implications for gene therapy were appreciated, and in practice the law has not been applied strictly to humans.

«This is the first piece of evidence that humans may have a faster rate» of change in the regulation of gene expression, notes Caro - Beth Stewart, a molecular evolutionist at the State University of New York, Albany.

Among the areas where the researchers have seen intriguing dissimilarities between humans and gorillas are in genes associated with sensory perception, keratin (a skin protein) production, insulin regulation, immunity, reproduction and cell signaling.

In a study published online in Genome Research, researchers devised a strategy for genome - wide annotation of primary miRNA transcripts, providing extensive new annotations in human and mouse, and shedding light on mechanisms of regulation of microRNA gene expression.

«The knowledge gained will help us understand many human disorders caused by malfunctions of gene regulation, a major goal of the NIH and of our new Institute for Genomics and Systems Biology in Chicago» White said.

Professor Segal's research has two major directions 1) Gene regulation — using quantitative and computational models to understand how DNA sequence variation among human individuals generates phenotypic diversity 2) Microbiome and Nutrition — understanding how the microbial composition of individuals affect their physiology and health.

Our technological expertise ranges from the most fundamental approaches to study membrane transport in lymphocytes and dendritic cells (subcellular compartmentalization, intravital microscopy, phagosomal functions), the systematic analysis of gene expression and it regulation (RNAseq, Chip Seq, proteomics) and physiological and pathological immune responses (mouse models for cancer immunity, immunomodulation / vaccination, human clinical studies in cancer).

His lab is interested in the regulation of gene expression by mRNA processing in C. elegans and human cells.

His research interests involve pharmacogenomics for hemoglobinopathies and neuropsychiatric disorders, transcriptional regulation of human fetal globin genes and genotype - phenotype correlation in human genetic disorders.

Genes that regulate Smn protein in mice may be involved in the regulation of SMN2 protein in humans.

Transgenic mice are extremely useful for scientists studying gene function or regulation and human diseases, such as Alzheimer's disease.

Using databases created by other labs, the Duke University scientists cross-checked areas of human DNA that had developed differences from chimp DNA with areas of DNA they expected to be important for gene regulation.

Since they confer regulation on the majority of human genes, it is not surprising that microRNAs are involved in numerous biological processes, including cardiovascular, immunological, neurodegenerative, and psychiatric diseases and cancer.

Liu's scientific research focuses on the functional genomics of human cancers, particularly breast cancer, uncovering new oncogenes, and deciphering on a genomic scale the dynamics of gene regulation that modulate cancer biology.

October 17, 2013 Gene regulation differences between humans and chimpanzees more complex than thought Changes in gene regulation have been used to study the evolutionary chasm that exists between humans and chimpanzees despite their largely identical Gene regulation differences between humans and chimpanzees more complex than thought Changes in gene regulation have been used to study the evolutionary chasm that exists between humans and chimpanzees despite their largely identical gene regulation have been used to study the evolutionary chasm that exists between humans and chimpanzees despite their largely identical DNA.

The answers they have discovered so far reveal critical information about gene regulation; specifically, that cells are used to record the positional identity in human tissues, and that the «perturbation,» the disturbance, of such programs plays a major role in cancer progression, especially in metastasis, whereby cancer cells spread to other parts of the body.

In the article describing the work in Molecular Therapy, co-authors Charis Himeda, Takako Jones and Peter Jones highlight the important implications for similar types of genetic diseases: «With increasing evidence that the repeat genome (comprising nearly half the human genome) plays important roles in gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they write.

Their preservation in the zebrafish allows us to visualize in this transparent genetic vertebrate model whether these variants are just neutral or if they disrupt the regulation of one the neighbor genes, possibly revealing the actual gene affected in AMD human patients.

The vast differences between humans and chimpanzees are due more to changes in gene regulation than differences in individual genes themselves, researchers from Yale, the University of Chicago, and the Hall Institute in Parkville, Victoria, Australia, argue in the March 9, 2006, issue of the journal Nature.

«For 30 years scientists have suspected that gene regulation has played a central role in human evolution,» said Kevin White, PhD, associate professor of genetics and ecology and evolution at Yale and senior author of the study.

That 1975 paper documented the 99 - percent similarity of genes from humans and chimps and suggested that altered gene regulation, rather than changes in coding, might explain how so few genetic changes could produce the wide anatomic and behavioral differences between the two.

Regulation of the expression of human ornithine decarboxylase gene and ornithine decarboxylase promoter - driven reporter gene in transgenic mice

To understand gene regulation, Panne works on a cell - free model of the human interferon beta response to viral infection.

Our computational biology research programme focuses on gene expression regulation and the mechanisms by which it can be disrupted in human diseases such as cancer.

The gene was mapped to a small region on chromosome 18, which previous studies have suggested may play a role in blood pressure regulation in humans, mice and rats.

• In nutrigenomics, the basic goal is to discover how diet affects metabolic pathways in the body and how this regulation may be disturbed in diet - related disease — i.e., humans with a certain mutated gene absorb higher levels of fat from the intestine, leading to elevated cholesterol and possible atherosclerosis.

Growth hormone (GH) receptors in prostate cancer: gene expression in human tissues and cell lines and characterization, GH signaling and androgen receptor regulation in LNCaP cells.

Identification of a novel sequence element in the common promoter region of human collagen type IV genes, involved in the regulation of divergent transcription

In this session, we review the recent advances in the identification of non-coding mutations and structural variations that influence gene regulation and their consequences for human disease.

268/4: 45 Identifying the transcription factors mediating enhancer — target gene regulation in the human genome.

In this session, we will discuss methods for integrated analysis of DNA and RNA and their application in human genomic research in the areas of cancer genomics, human disease research, and regulation of gene expression.

TiGER (Tissue - specific Gene Expression and Regulation) is a database that provides comprehensive information about postnatal human tissue - specific gene regulation, including expression (from EST studies) and regulatory elemeGene Expression and Regulation) is a database that provides comprehensive information about postnatal human tissue - specific gene regulation, including expression (from EST studies) and regulatoryRegulation) is a database that provides comprehensive information about postnatal human tissue - specific gene regulation, including expression (from EST studies) and regulatory elemegene regulation, including expression (from EST studies) and regulatoryregulation, including expression (from EST studies) and regulatory elements.

The immunopurification (IP) of Argonaute (Ago), a central component of the RISC in the human and mouse, followed by microarray analyses (Ago IP / microarray method) makes it possible to isolate any Ago - associated miRNAs and mRNAs without relying on the mechanism of regulation (i.e. mRNA decay or translational suppression), or sequence conservation, enabling a comprehensive identification of the miRNA - target genes in an unbiased manner.

The San Diego Epigenome Center, headed by Bing Ren, Ph.D., Professor of Cellular and Molecular Medicine at the University of California, San Diego School of Medicine and head of the Laboratory of Gene Regulation at the Ludwig Institute for Cancer Research, is an integral part of the five - year, $ 190 million push to accelerate research into modifications that alter genetic behavior across the human genome.

Gene & Kinna fully support the protection of wild areas on the planet as well as laws and regulations which minimize the human impacts on the earth.