Sentences with phrase «human genes reveals»

A new catalog of human genes reveals that people have many different ways to build proteins.

Not exact matches

This approach revealed a highly sensitive portrait of the genes being expressed in human milk - making cells.

Citation: Lemay DG, Ballard OA, Hughes MA, Morrow AL, Horseman ND, Nommsen - Rivers LA (2013) RNA Sequencing of the Human Milk Fat Layer Transcriptome Reveals Distinct Gene Expression Profiles at Three Stages of Lactation.

However, this study revealed that mice are more similar to humans than previously thought, with an average of around 10 % of active genes escaping X-inactivation per tissue.

The human (and all the other) genome projects were predicated on the reasonable assumption that spelling out the full sequence of genes would reveal the source of that diversity of form and attributes that so readily distinguish worm from fly, mouse, chimp and human.

Researchers working in the Development and Growth Control Lab at IRB Barcelona reveal that the Dpp gene (BMP in humans) plays a double role in the structural organisation and growth of the wings of the fruit fly Drosophila melanogaster.

«Brain genes related to innovation revealed in birds: Glutamate brain receptors, linked with human intelligence, are also associated with problem - solving skills in wild birds.»

The goal of the human genome project was to use DNA sequencing to reveal all three billion DNA letters in our chromosomes and find all our genes.

The study not only shows that NPTX2 is active in kidney cancer, but is the first to reveal that the gene is over-expressed in any human cancer.

«The elephant results revealed noncoding sequences in the human genome that we predict may control gene activity and reduce the formation of mutations and cancer.»

When his team looked at gene expression changes in the mice, then applied them to humans with early stage cancer, the results revealed a breakdown of which patients have a high or low chance of survival.

The title of the paper is «Bioinformatic analysis reveals a pattern of STAT3 - associated gene expression specific to basal - like breast cancers in human tumors.»

Extinct human cousins may have used some genes differently than modern people do, an analysis of Neandertal and Denisovan DNA reveals.

The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response of breast and ovarian tumor cells to common classes of chemotherapy treatment.

SEATTLE — Apparently ending several years of uncertainty, an official of the U.S. Patent and Trademark Office (PTO) revealed here today that the government intends to grant patents on expressed sequence tags (ESTs), human DNA sequences of up to a few hundred base pairs in length that can be used to identify and detect the expression of specific genes.

Whole genome sequencing of modern and ancient horses unveils the genes that have been selected by humans in the process of domestication through the latest 5,500 years, but also reveals the cost of this domestication.

Researchers have harnessed the chemical degradation of fossil DNA to determine methylation patterns that may reveal which genes were turned on, or off, in ancient human species.

Tomas Marques - Bonet of the Universitat Pompeu Fabra noted that studying gene flow between ancient humans such as Neanderthals, Denisovans and the ancestors of modern humans has revealed numerous genes under selection that affect disease and an individual's traits.

«Today, rapidly falling costs means that high throughput sequencing projects are revealing the entire gene sequences of ever more species, but the biological functions of most of these genes remain unknown,» said Dr. Olivier Lichtarge, professor of molecular and human genetics and director of the Computational and Integrative Biomedical Research Center at Baylor and senior author of the report.

Indeed, a close look at the chimp genome reveals an important lesson in how genes and evolution work, and it suggests that chimps and humans are a lot more similar than even a neurobiologist might think.

The first results of gene editing in viable human embryos reveals it works better than we thought, but that there's another big problem blocking the way

The findings, now published in PLOS Genetics, reveal how mice can actually mimic human breast cancer tissue and its genes, even more so than previously thought, as well as other cancers including lung, oral and esophagus.

A study carried out by the Laboratoire Neurobiologie des Interactions Cellulaires et Neurophysiopathologie (CNRS / Aix - Marseille Université), in collaboration with clinicians from Marseilles Public Hospitals (AP - HM) and scientists from the Salk Institute in San Diego (US), has revealed a new gene that plays a crucial role during early development in humans and whose under - expression may induce certain autistic traits.

Thinking they may have hit upon a useful gene that could reveal disease pathways, his group searched to see if the mouse mutation could also be found in schizophrenic humans.

More sensitive cultivation methods and precise 16S rRNA gene sequencing techniques have revealed that the human bladder hosts a significant microbiome and those diverse bacteria inside the bladder impact pediatric urologic diseases.

«We found hundreds of genes expressed exclusively by human astrocytes, and future studies will likely reveal additional biological differences.

The degree of DNA similarity didn't necessarily indicate whether a human gene could stand in for a yeast gene, Marcotte and colleagues reveal online today in Science.

Previous studies have revealed that human hair, reptile scales and bird feathers evolved from a single ancestor — a reptile that lived 300 million years ago — but this new study from the Fraser Lab at Sheffield has found that the skin teeth found on sharks also developed from the same genes.

Whereas liver and blood gene activity patterns showed the expected differences among the three groupswith human transcription looking similar to that of the chimp, and different from that of the more evolutionarily distant macaquegene activity in the brain revealed stark differences between humans and chimps.

Furthermore, by comparing the patterns of change in humans and chimpanzees, it was revealed that HAR - associated schizophrenia genes were under stronger evolutionary selective pressure than other schizophrenia genes.

But a comparison of its DNA to that of another human has revealed several mutations in genes involved in bone disorders — and confirmed once and for all that this being is definitely from our world.

A scan for human - specific relaxation of negative selection reveals unexpected polymorphism in proteasome genes.

A scan for human - specific relaxation of negative selection reveals unexpected polymorphism in proteasome genes Somel, M., M. A. W. Sayres, G. Jordan, E. Huerta - Sanchez et al. 2013.

Researchers are finding many genes unique to our species, but so far they reveal little about our most human traits.

A detailed comparison of gene expression signatures between ETP ALL tumors and and normal human hematopoietic progenitor cells revealed a somewhat surprising finding: ETP - ALL expression patterns were less consistent with early T - cell precursors, as might have been expected, but more similar to the expression profile of normal hematopoietic stem cells and granulocyte macrophage precursors.

Matching DPI peaks to the 5 ′ end of known genes within 500 bp revealed that 91 % of human protein - coding genes had a TSS supported by robust CAGE peaks.

For instance, the mouse sequence revealed that mice have two genes related to the gene involved in Lowe's syndrome, an inherited metabolic disorder in humans.

Human Biology Division discovery reveals that the CTCF protein that forms protective boundaries between inactive, active sets of genes; may shed light on how some cancers develop

Familial Dysautonomia (FD) Human Embryonic Stem Cell Derived PNS Neurons Reveal that Synaptic Vesicular and Neuronal Transport Genes Are Directly or Indirectly Affected by IKBKAP Downregulation.

High Throughput Screening for Inhibitors of Rest in Neural Derivatives of Human Embryonic Stem Cells Reveals a Chemical Compound that Promotes Expression of Neuronal Genes

With the reference cell census data in hand, the research team is excited to conduct additional studies, including ones involving models or human patients with gastrointestinal conditions — Crohn's disease, ulcerative colitis, gastrointestinal cancers, forms of food allergy, etc. — aimed at identifying changes in gene expression and epithelial structure and function that could reveal new insights and opportunities for therapeutic development.

Already, the genome's tales are revealing how genetic variants contribute to disease, giving researchers insights into human evolution and even changing how scientists define a gene.

This revealed, despite the high overall genomic conservation of the region, remarkable differences of the gene content between human and mouse.

«The human genome sequence provided a blueprint of all the protein - coding genes in the human genome for the first time,» reveals Jan Ellenberg, Head of the Cell Biology and Biophysics Unit at EMBL Heidelberg, «this changed how we go about studying protein function.»

The answers they have discovered so far reveal critical information about gene regulation; specifically, that cells are used to record the positional identity in human tissues, and that the «perturbation,» the disturbance, of such programs plays a major role in cancer progression, especially in metastasis, whereby cancer cells spread to other parts of the body.

Gonzalez - Porta, M., Frankish, A., Rung, J., Harrow, J. & Brazma, A. Transcriptome analysis of human tissues and cell lines reveals one dominant transcript per gene.

The revolution in human genetics has revealed a large number of genes and pathways associated with these diseases, and emerging methodologies are starting to systematically analyze the cellular and molecular circuitry underlying disease.

Their preservation in the zebrafish allows us to visualize in this transparent genetic vertebrate model whether these variants are just neutral or if they disrupt the regulation of one the neighbor genes, possibly revealing the actual gene affected in AMD human patients.

While this is a much more complex and daunting undertaking, by understanding the functions and network interactions of genes and proteins — both human and microbe — we will ultimately gain far greater insight into human health and reveal more solutions to dread diseases.

Large - scale cellular - resolution gene profiling in human neocortex reveals species - specific molecular signatures.