Because people exposed to Ebola show phenotypic variability in susceptibility to infection and disease severity, it is likely that
human genetic variation contributes to individual immunity and infectivity and that host genetic differences are one factor among many that interact to influence the infection.
Not exact matches
Many other geographic, climatic, and historical factors have
contributed to the patterns of
human genetic variation seen in the world today.
Among other initiatives, his group
contributes to ENCODE (Encyclopedia of DNA Elements), supported by NIH to define functional genomic elements; the DOE Systems Biology Knowledgebase (KBase) for data sharing and analysis; and the internationally funded 1000 Genomes Project on
human genetic variation.
Several lines of evidence suggest that a person's facial shape is controlled by one's genes, but scientists don't yet understand how
genetic variation contributes to the range of healthy shapes and sizes that
human faces take.
He's interested in understanding how non-coding
genetic variation contributes to
human traits by integrating the genome and transcriptome.
His research focuses on understanding the role of
genetic variation in
contributing to
human health and disease using mouse models of
human disease, and more recently exploiting technologies developed for biomedical research for application in the field of
genetic pest management.