Sentences with phrase «human genome analysis»

Nagen aims to transfer the use of the latest technology of complete human genome analysis to Navarra's public health network.

Not exact matches

By increasing the speed and accuracy for NGS data analysis like whole genome sequencing (WGS), our computing platform makes it easier to discover links between DNA sequence variations and human disease.»

The analysis revealed that the human genome is organized into large pieces of low or high epigenetic stochasticity, and that these regions correspond to areas of chromosomes that are structurally different in the cell nucleus.

The mouse, dog and human genomes are of high quality whereas the three others are at different stages of analysis completion.»

An analysis of the HPV16 genome from 5,570 human cell and tissue samples revealed that the virus actually consists of thousands of unique genomes, such that infected women living in the same region often have different HPV16 sequences and variable risks to cancer.

Producing a short list of strong candidates was in itself a feat, accomplished by applying the right filters to analysis of human and chimpanzee genomes, said co-author Gregory Wray, professor of biology and director of the Duke Center for Genomic and Computational Biology.

Now Pääbo and his colleagues have devised a new method of genetic analysis that allowed them to reconstruct the entire Denisovan genome with nearly all of the genome sequenced approximately 30 times over akin to what we can do for modern humans.

Using metabolic function analyses of identified genes, we compared our human genome with the average content of previously sequenced microbial genomes.

Using advanced sequencing technologies, University of Oklahoma anthropologists demonstrate that human DNA can be significantly enriched from dental calculus (calcified dental plaque) enabling the reconstruction of whole mitochondrial genomes for maternal ancestry analysis — an alternative to skeletal remains in ancient DNA investigations of human ancestry.

Human DNA can be significantly enriched from dental calculus (calcified dental plaque) enabling the reconstruction of whole mitochondrial genomes for maternal ancestry analysis — an alternative to skeletal remains in ancient DNA investigations of human anceHuman DNA can be significantly enriched from dental calculus (calcified dental plaque) enabling the reconstruction of whole mitochondrial genomes for maternal ancestry analysis — an alternative to skeletal remains in ancient DNA investigations of human ancehuman ancestry.

In - depth analysis of the human body's microflora has been possible only in the past few years — a by - product of the same new gene sequencing techniques that have allowed scientists to cheaply and accurately identify the DNA of the human genome.

«To me, one of the most exciting discoveries to come out of that analysis [of the Neandertal genome] was that there was admixture between modern humans and Neandertals.

«Gene variants modifying Huntington's symptom onset may lead to new therapeutic strategies: Genome - wide association analysis identifies sites associated with earlier - or later - than - expected symptom appearance in human patients.»

Among other initiatives, his group contributes to ENCODE (Encyclopedia of DNA Elements), supported by NIH to define functional genomic elements; the DOE Systems Biology Knowledgebase (KBase) for data sharing and analysis; and the internationally funded 1000 Genomes Project on human genetic variation.

The genome - wide analyses showed that Cpf1 was highly specific, showing fewer off - target cleavage sites (6 for LbCpf1 and 12 for AsCpf1), compared to Cas9, cleaving at > 90 sites in the human genome (Fig. 1a).

Much of the work will therefore demand comparative analyses of the genomes and phenotypes of large numbers of humans and apes.

Careful attention to phenotyping diseases, facilitated by our knowledge of the human genome and computational analysis, has allowed observant physicians and physician - scientists to identify and categorize diseases in a manner that has informed basic science, given it new contexts, and in many instances provided important new directions for investigation.

The sequencing of the human genome is gearing up all those efforts, and with each novel model organism for which the sequence has been determined, the power of comparative analysis increases.

To identify the genes that give rise to the palette of human skin tones, Crawford et al. applied genome - wide analyses across diverse African populations (see the Perspective by Tang and Barsh).

«St. Laurent Institute has adapted true single - molecule sequencing technology to global transcriptome analysis, providing state - of - the - art technology for the measurement of the output of the human genome,» said Georges St. Laurent III, Scientific Director of the St. Laurent Institute.

Subsequent analysis of two - thirds of the genome in the 2009 A (H1N1) isolated from more than a dozen pigs shows that it closely matches the human version of the virus.

Just as the Human Genome Initiative in the 1990s sequenced human DNA for the subsequent identification and analysis of genes, so too will the Materials Genome Initiative sequence materials for identifying new properties for a variety of applicatHuman Genome Initiative in the 1990s sequenced human DNA for the subsequent identification and analysis of genes, so too will the Materials Genome Initiative sequence materials for identifying new properties for a variety of applicathuman DNA for the subsequent identification and analysis of genes, so too will the Materials Genome Initiative sequence materials for identifying new properties for a variety of applications.

As scientists race to decode genomes — not just of humans but of bacteria, yeast, chimps, dogs, whales and plants — the number of DNA sequences available for analysis has grown 40,000-fold in the past 20 years, providing unprecedented insight into billions of years of species evolution.

Conducting the first large - scale, genome - wide analyses of ancient human remains from the Near East, an international team led by Harvard Medical School has illuminated the genetic identities and population dynamics of the world's first farmers.

We test this hypothesis through phylogenetic analysis on 48 avian genomes we collected or assembled, representing all commonly accepted extant neognath orders (36, 37) and two palaeognaths, with several nonavian reptiles and human as outgroups.

A genome analysis suggests that Asian and Pacific human populations share a single origin and their ancestors might have bred with Homo erectus

The genome analysis also questions previous findings that modern humans populated Asia in two waves from their origin in Africa, finding instead a common origin for all populations in the Asia - Pacific region, dating back to a single out - of - Africa migration event.

The high degree of similarity between the mouse and human genomes is demonstrated through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a whole - genome shotgun assembly of the mouse genome.

Today, Francis Collins, director of the U.S. National Human Genome Research Institute, emphasized the similarity between the two group's initial analyses.

The Human Genome Project so increased the speed with which researchers can generate data that the bottleneck no longer lies in data generation but in data analysis.

«Analysis of dog genome will provide insight into human disease.»

Dr. Gitlin is a Science Policy Analyst within the Policy and Program Analysis Branch (PPAB) of the Office of the Director at the National Human Genome Research Institute.

An important model in studying human disease, the non-coding RNA of the canine genome is an essential starting point for evolutionary and biomedical studies, according to a new study led by The Genome Analysis Centre (genome is an essential starting point for evolutionary and biomedical studies, according to a new study led by The Genome Analysis Centre (Genome Analysis Centre (TGAC).

Although the Green et al. analyses are suggestive of admixture, the role of Neandertals in the genetic ancestry of humans outside of Africa was likely relatively minor given that only a few percent of the genomes of present - day people outside of Africa appear to be derived from Neandertals.

Some of the most profound insights in the crucial role of microbes for human well - being have emerged from analyses of the microbes on and in our bodies — their genomes, transcriptomes, proteomes and metabolomes.

The assembly and analysis of human tumor cell genomes, many of which contain chromosome deletions, duplications and insertions, as well as single nucleotide changes, requires immense data storage capacity and high - speed computation.

NORMAN — Using advanced sequencing technologies, University of Oklahoma anthropologists demonstrate that human DNA can be significantly enriched from dental calculus (calcified dental plaque) enabling the reconstruction of whole mitochondrial genomes for maternal ancestry analysis — an alternative to skeletal remains in ancient DNA investigations of human ancestry.

In their genome analysis, the researchers discovered that the genetic information of the gibbons differs in their entirety from that of humans and of apes.

2002 - EMBL participates in completion and analysis of human and other genomes, made publicly accessible on EMBL - EBI's Ensembl website.

Previously, I led the human genetics analysis group of the McDonnell Genome Institute at Washington University in St. Louis.

ENSEMBL makes available substantial and diverse transcript information, including the CCDS [13, 41], Human and Vertebrate Analysis and Annotation (HAVANA)[42], Vertebrate Genome Annotation (Vega)[43], ENCODE data [12] and the GENCODE gene and transcript sets [15].

The most significant of these was the HiSeq X Ten, a 10 - instrument «factory installation» that enabled the most cost - effective human whole genome sequencing to date: 18,000 genomes per year at a consumables cost of just over $ 1,000 each (note: this does not include the costs of data storage, analysis, or the $ 10 million buy - in).

Proteomics (Fagerberg et al, «Analysis of the human tissue - specific expression by genome - wide integration of transcriptomics and antibody - based proteomics») with a focus in the article on the tissue - specific pattern in the human body.

We will take the user from a beginner level understanding to one that can analysis multiple whole human genomes and derive meaningful clinical results using the latest methodologies.

An assembly and annotation of the first draft sequence of the entire human genome that includes a comprehensive analysis of repeated DNA sequences.

Initial sequencing and analysis of the human genome.

Cristina Kapustij, M.S., has been named chief of the Policy and Program Analysis Branch (PPAB) at the National Human Genome Research Institute (NHGRI).

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells.

The Cancer, Ageing and Somatic Mutation Programme encompasses three Projects that respectively cover the genomics of human cancers; functional analysis of the cancer genome using a range of in vitro and in vivo model systems; and the characterisation of somatic mutations in development and adult homeostasis in health and disease.

Identification of a human papillomavirus - associated oncogenic miRNA panel in human oropharyngeal squamous cell carcinoma validated by bioinformatics analysis of the Cancer Genome Atlas.