Sentences with phrase «human genomic sequence»

Scientific programs include: human genomic sequencing and analysis, synthetic genomics and exploration of new vaccines using this technology, and environmental and single cell genomics to explore the vast unseen world of microbes living in the human body, the ocean, soil and air.

Not exact matches

Just last month, the genomic sequencing company Illumina announced it had developed a genome sequencer that can map the human genome for just $ 1,000.

Using advances in genomic sequencing, the human microbiome, proteomics, informatics, computing, and cell therapy technologies, HLI is building the world's most comprehensive database of human genotypes and phenotypes as a basis for a variety of commercialization opportunities to help solve aging related disease and human biological decline.

«However, because SIF - seq only requires DNA sequence from a mammal and can be used in a variety of cell types, it should be possible to compare the neuronal enhancers present in a large genomic region from human to the neuronal enhancers present in the orthologous chimpanzee region.

«The human part of it really got a lot of people overly excited, and that kind of overshadowed the intent to make it be about writing genomic sequences in general,» Boeke says.

The move comes in response to the announcement earlier this week of a new U.S. company, launched by sequencing - machine manufacturer Perkin - Elmer and J. Craig Venter of The Institute for Genomic Research, that plans a brute - force approach to sequencing the human genome within 3 years (ScienceNOW, 12 May).

«With large present - day genomic datasets and increased international collaboration to handle the many newly sequenced ancient datasets, there is huge potential to understand the biology of human prehistory in a way that has never been accessible before.»

Cell - free genomic DNA isolated from human cells was cleaved with preassembled, recombinant Cpf1 RNPs and subjected to whole - genome sequencing.

Yet a third player in the emerging algae fuel market is Synthetic Genomics, the brainchild of genomics guru Craig Venter, who beat the U.S. government in sequencing the human genome and at a fraction of the cost.

Sequencing technology has advanced so far that, these days, fresh evolutionary insights do not necessarily require any fossils at all: Within our DNA, we modern humans provide a genomic window onto what came before.

They digested human genomic DNA using Cas9 nucleases in a test tube, which was then subjected by whole genome sequencing.

People with heart disorders also have higher than average levels of certain bacteria, according to genomic sequencing of the human gut.

His laboratory develops and deploys new biochemical and computational methods in functional genomics, to elucidate the genetic basis of human disease and human physiology, and to create and deploy novel techniques in next - generation sequencing and algorithms for tumor evolution, genome evolution, DNA and RNA modifications, and genome / epigenome engineering.

They embark on wild flights of fancy, single - handedly coming up with a cure for AIDS, a new method for genomic sequencing, and the key to human evolution before you've even finished your morning coffee.

Indeed, according to a report last year by the research and management organization Battelle, «In 2010 alone, the human genome sequencing projects and associated genomics research and industry activity directly and indirectly generated $ 67 billion in U.S. economic output and supported 310,000 jobs that produced $ 20 billion in personal income.»

For Neandertal genomics to come into its own, however, Pääbo, Rubin, and others must demonstrate that their sequences are real and not a mosaic of errors due to degradation that occurs as DNA ages, sequencing mistakes, or contamination from modern humans who have handled the fossils, says genomicist Stephan Schuster of Pennsylvania State University in State College.

A decision to release the genomic sequence data, which likely won't be announced for several weeks, would represent a victory for scientists who favor rapid distribution of human DNA sequences on the Internet.

Derived mostly from human embryonic kidney 293T (HEK293T) and HeLa cell lines, EdiGene Knockout (KO) Cell Lysates have been optimized through the use of genome editing technology and validated at the genomic level through PCR and Sanger - sequencing techniques to ensure the accuracy and knockout of the target gene.

Elodie Ghedin, a biomedical researcher at the University of Pittsburgh in Pennsylvania, who uses genomic sequencing techniques to generate insights into human pathogens.

Complementary DNA and genomic clones were isolated and sequenced corresponding to rat and human synaptophysin (p38), a major integral membrane protein of synaptic vesicles.

Although humans and their closest evolutionary relatives, the chimpanzees, are 98.7 % identical in their genomic DNA sequences, they differ in many morphological, behavioral, and cognitive aspects.

«The availability of the human genome sequence, as well as other genomic resources produced by our sequencing centers, has transformed biomedical research everywhere,» said NHGRI's Associate Director of Extramural Research Jane Peterson, Ph.D., who is also a program director for NHGRI's Large - Scale Sequencing Researcsequencing centers, has transformed biomedical research everywhere,» said NHGRI's Associate Director of Extramural Research Jane Peterson, Ph.D., who is also a program director for NHGRI's Large - Scale Sequencing ResearcSequencing Research Network.

For example, the large - scale sequencing program has already started to sequence the genomes of 100 microorganisms found in the human gut, and will build on this by using genomic sequencing to characterize the complex microbial communities found at many sites in and on the human body.

From sequencing the first human genome to conducting some of the earliest work in understanding the human gut microbiome, JCVI researchers are pioneers in mammalian genomics.

In the post-genomic era, we are witnessing significant advances in the functional decipherment of the human genome sequence that have been made possible by new technological developments in the field of genomic medicine.

And let's face it, exome sequencing lets us conveniently avoid some of the most challenging aspects of human genomics, like detecting complex rearrangements (SVs) and interpreting noncoding regulatory variants.

The advent of accessible and relatively inexpensive high - throughput sequencing technology has resulted in extensive sequencing of whole human genomes or exomes in a research setting and seems likely to lead to an explosion of genomic sequencing in a clinical context.

Along with the genomic data gleaned from the sequencing of complete human genomes, HLI will also be generating microbiome data for many of these individuals through its Biome Healthcare division, under the leadership of Karen Nelson, Ph.D..

Jacques Genest report in this scientific article that there are a bewildering number of scientific databases for genomics, DNA sequences, proteomics, and metabolomics that are open access or require institutional (for a fee) access available for researchers especially in Human variant databases.

Founded by J. Craig Venter, Ph.D., the JCVI is home to approximately 300 scientists and staff with expertise in human and evolutionary biology, genetics, bioinformatics / informatics, information technology, high - throughput DNA sequencing, genomic and environmental policy research, and public education in science.

Major focus areas include human genome interpretation and genetic dissection of novel rare diseases, predictive genomic signatures of response to therapy — especially cancer therapy, and novel sequencing - based assays as biomarkers of disease.

Using advances in genomic sequencing, the human microbiome, proteomics, informatics, computing, and cell therapy technologies, HLI is building the world's most comprehensive database of human genotypes and phenotypes as a basis for a variety of commercialization opportunities to help solve aging related disease and human biological decline.

Scientists are predicting that genomics — the field of sequencing human DNA — will soon take the lead as the biggest data beast in the world, eventually creating more digital information than astronomy, particle physics and even popular Internet sites like YouTube.

Right now, all of the human data generated through genomics — including around 250,000 sequences — takes up about a fourth of the size of YouTube's yearly data production.

To assess the speed with which both humans and chimpanzees accumulated many small differences in gene sequences accurately, Wu and colleagues in Taiwan and Japan decided to sequence several thousand genes expressed in the brain of the macaque monkey and compare them with available genomic sequences from human, chimpanzee, and mice.

In 2012, Dr. Torkamani advanced to Director of Genome Informatics at STSI where he leads various human genome sequencing and other genomics initiatives.

Biological Annotation of the Genomic Sequence A key use of the sequence information from the canonical model organisms, such as Drosophila, will be to help interpret the sequence of the humanSequence A key use of the sequence information from the canonical model organisms, such as Drosophila, will be to help interpret the sequence of the humansequence information from the canonical model organisms, such as Drosophila, will be to help interpret the sequence of the humansequence of the human genome.

HLI is using genomic sequencing, the human microbiome, proteomics and advanced computing to tackle aging - related human diseases.

She has made an important contribution to several international research consortia in human genomics, including the Genotype Tissue Expression (GTEx) Project, the 1000 Genomes Project and led the RNA - sequencing work of the Geuvadis Consortium.

It is likely that genomic variation in conserved non-genic sequences is associated with phenotypic variability and human disorders.

BETHESDA, Md., Thurs., Oct. 14, 2004 - The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), today announced it has awarded more than $ 38 million in grants to spur the development of innovative technologies designed to dramatically reduce the cost of DNA sequencing, a move aimed at broadening the applications of genomic information in medical research and health care.

In the article describing the work in Molecular Therapy, co-authors Charis Himeda, Takako Jones and Peter Jones highlight the important implications for similar types of genetic diseases: «With increasing evidence that the repeat genome (comprising nearly half the human genome) plays important roles in gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they write.

Interface of Genomics Research and Genomic Medicine Recent advances in DNA sequencing technologies mean that it is now possible to conduct genomic analyses, including analysis of the entire genome of an individual human, that just a few years ago would have been too costly anGenomic Medicine Recent advances in DNA sequencing technologies mean that it is now possible to conduct genomic analyses, including analysis of the entire genome of an individual human, that just a few years ago would have been too costly angenomic analyses, including analysis of the entire genome of an individual human, that just a few years ago would have been too costly and slow.

I took these comparative genomic scans to the next level by writing a computer program to identify DNA sequences that are conserved in other animals but have changed rapidly in humans since we evolved from our common ancestor with chimpanzees.

In the latest issue of Philosophical Transactions of the Royal Society B, researchers in the laboratory of Gladstone Investigator Katherine Pollard, PhD, use the latest sequencing and bioinformatics tools to find genomic regions that guide the development of human - specific characteristics.

Designing primers against genomic DNA to amplify the gRNA targets was challenging because you're limited by the sequence of the human genome.

His laboratory has also discovered and characterized a significant number of novel genes contributing to autism and human neurodevelopmental disorders, and has recently applied whole - genome sequencing technologies and large - scale genomics datasets to prenatal detection and interpretation of structural variation in the genome.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

«I was looking to see if I could find genomic regions where the Altai Neanderthal has sequences resembling those we see in humans,» says Martin Kuhlwilm.

He played a vital role in annotating the genome sequences of human, mouse, chicken and several other organisms; this work has had a profound impact on our understanding of genomic biology.