Scientific programs include:
human genomic sequencing and analysis, synthetic genomics and exploration of new vaccines using this technology, and environmental and single cell genomics to explore the vast unseen world of microbes living in the human body, the ocean, soil and air.
Not exact matches
Just last month, the
genomic sequencing company Illumina announced it had developed a genome sequencer that can map the
human genome for just $ 1,000.
Using advances in
genomic sequencing, the
human microbiome, proteomics, informatics, computing, and cell therapy technologies, HLI is building the world's most comprehensive database of
human genotypes and phenotypes as a basis for a variety of commercialization opportunities to help solve aging related disease and
human biological decline.
«However, because SIF - seq only requires DNA
sequence from a mammal and can be used in a variety of cell types, it should be possible to compare the neuronal enhancers present in a large
genomic region from
human to the neuronal enhancers present in the orthologous chimpanzee region.
«The
human part of it really got a lot of people overly excited, and that kind of overshadowed the intent to make it be about writing
genomic sequences in general,» Boeke says.
The move comes in response to the announcement earlier this week of a new U.S. company, launched by
sequencing - machine manufacturer Perkin - Elmer and J. Craig Venter of The Institute for
Genomic Research, that plans a brute - force approach to
sequencing the
human genome within 3 years (ScienceNOW, 12 May).
«With large present - day
genomic datasets and increased international collaboration to handle the many newly
sequenced ancient datasets, there is huge potential to understand the biology of
human prehistory in a way that has never been accessible before.»
Cell - free
genomic DNA isolated from
human cells was cleaved with preassembled, recombinant Cpf1 RNPs and subjected to whole - genome
sequencing.
Yet a third player in the emerging algae fuel market is Synthetic
Genomics, the brainchild of
genomics guru Craig Venter, who beat the U.S. government in
sequencing the
human genome and at a fraction of the cost.
Sequencing technology has advanced so far that, these days, fresh evolutionary insights do not necessarily require any fossils at all: Within our DNA, we modern
humans provide a
genomic window onto what came before.
They digested
human genomic DNA using Cas9 nucleases in a test tube, which was then subjected by whole genome
sequencing.
People with heart disorders also have higher than average levels of certain bacteria, according to
genomic sequencing of the
human gut.
His laboratory develops and deploys new biochemical and computational methods in functional
genomics, to elucidate the genetic basis of
human disease and
human physiology, and to create and deploy novel techniques in next - generation
sequencing and algorithms for tumor evolution, genome evolution, DNA and RNA modifications, and genome / epigenome engineering.
They embark on wild flights of fancy, single - handedly coming up with a cure for AIDS, a new method for
genomic sequencing, and the key to
human evolution before you've even finished your morning coffee.
Indeed, according to a report last year by the research and management organization Battelle, «In 2010 alone, the
human genome
sequencing projects and associated
genomics research and industry activity directly and indirectly generated $ 67 billion in U.S. economic output and supported 310,000 jobs that produced $ 20 billion in personal income.»
For Neandertal
genomics to come into its own, however, Pääbo, Rubin, and others must demonstrate that their
sequences are real and not a mosaic of errors due to degradation that occurs as DNA ages,
sequencing mistakes, or contamination from modern
humans who have handled the fossils, says genomicist Stephan Schuster of Pennsylvania State University in State College.
A decision to release the
genomic sequence data, which likely won't be announced for several weeks, would represent a victory for scientists who favor rapid distribution of
human DNA
sequences on the Internet.
Derived mostly from
human embryonic kidney 293T (HEK293T) and HeLa cell lines, EdiGene Knockout (KO) Cell Lysates have been optimized through the use of genome editing technology and validated at the
genomic level through PCR and Sanger -
sequencing techniques to ensure the accuracy and knockout of the target gene.
Elodie Ghedin, a biomedical researcher at the University of Pittsburgh in Pennsylvania, who uses
genomic sequencing techniques to generate insights into
human pathogens.
Complementary DNA and
genomic clones were isolated and
sequenced corresponding to rat and
human synaptophysin (p38), a major integral membrane protein of synaptic vesicles.
Although
humans and their closest evolutionary relatives, the chimpanzees, are 98.7 % identical in their
genomic DNA
sequences, they differ in many morphological, behavioral, and cognitive aspects.
«The availability of the
human genome
sequence, as well as other
genomic resources produced by our
sequencing centers, has transformed biomedical research everywhere,» said NHGRI's Associate Director of Extramural Research Jane Peterson, Ph.D., who is also a program director for NHGRI's Large - Scale Sequencing Researc
sequencing centers, has transformed biomedical research everywhere,» said NHGRI's Associate Director of Extramural Research Jane Peterson, Ph.D., who is also a program director for NHGRI's Large - Scale
Sequencing Researc
Sequencing Research Network.
For example, the large - scale
sequencing program has already started to
sequence the genomes of 100 microorganisms found in the
human gut, and will build on this by using
genomic sequencing to characterize the complex microbial communities found at many sites in and on the
human body.
From
sequencing the first
human genome to conducting some of the earliest work in understanding the
human gut microbiome, JCVI researchers are pioneers in mammalian
genomics.
In the post-
genomic era, we are witnessing significant advances in the functional decipherment of the
human genome
sequence that have been made possible by new technological developments in the field of
genomic medicine.
And let's face it, exome
sequencing lets us conveniently avoid some of the most challenging aspects of
human genomics, like detecting complex rearrangements (SVs) and interpreting noncoding regulatory variants.
The advent of accessible and relatively inexpensive high - throughput
sequencing technology has resulted in extensive
sequencing of whole
human genomes or exomes in a research setting and seems likely to lead to an explosion of
genomic sequencing in a clinical context.
Along with the
genomic data gleaned from the
sequencing of complete
human genomes, HLI will also be generating microbiome data for many of these individuals through its Biome Healthcare division, under the leadership of Karen Nelson, Ph.D..
Jacques Genest report in this scientific article that there are a bewildering number of scientific databases for
genomics, DNA
sequences, proteomics, and metabolomics that are open access or require institutional (for a fee) access available for researchers especially in
Human variant databases.
Founded by J. Craig Venter, Ph.D., the JCVI is home to approximately 300 scientists and staff with expertise in
human and evolutionary biology, genetics, bioinformatics / informatics, information technology, high - throughput DNA
sequencing,
genomic and environmental policy research, and public education in science.
Major focus areas include
human genome interpretation and genetic dissection of novel rare diseases, predictive
genomic signatures of response to therapy — especially cancer therapy, and novel
sequencing - based assays as biomarkers of disease.
Using advances in
genomic sequencing, the
human microbiome, proteomics, informatics, computing, and cell therapy technologies, HLI is building the world's most comprehensive database of
human genotypes and phenotypes as a basis for a variety of commercialization opportunities to help solve aging related disease and
human biological decline.
Scientists are predicting that
genomics — the field of
sequencing human DNA — will soon take the lead as the biggest data beast in the world, eventually creating more digital information than astronomy, particle physics and even popular Internet sites like YouTube.
Right now, all of the
human data generated through
genomics — including around 250,000
sequences — takes up about a fourth of the size of YouTube's yearly data production.
To assess the speed with which both
humans and chimpanzees accumulated many small differences in gene
sequences accurately, Wu and colleagues in Taiwan and Japan decided to
sequence several thousand genes expressed in the brain of the macaque monkey and compare them with available
genomic sequences from
human, chimpanzee, and mice.
In 2012, Dr. Torkamani advanced to Director of Genome Informatics at STSI where he leads various
human genome
sequencing and other
genomics initiatives.
Biological Annotation of the
Genomic Sequence A key use of the sequence information from the canonical model organisms, such as Drosophila, will be to help interpret the sequence of the human
Sequence A key use of the
sequence information from the canonical model organisms, such as Drosophila, will be to help interpret the sequence of the human
sequence information from the canonical model organisms, such as Drosophila, will be to help interpret the
sequence of the human
sequence of the
human genome.
HLI is using
genomic sequencing, the
human microbiome, proteomics and advanced computing to tackle aging - related
human diseases.
She has made an important contribution to several international research consortia in
human genomics, including the Genotype Tissue Expression (GTEx) Project, the 1000 Genomes Project and led the RNA -
sequencing work of the Geuvadis Consortium.
It is likely that
genomic variation in conserved non-genic
sequences is associated with phenotypic variability and
human disorders.
BETHESDA, Md., Thurs., Oct. 14, 2004 - The National
Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), today announced it has awarded more than $ 38 million in grants to spur the development of innovative technologies designed to dramatically reduce the cost of DNA
sequencing, a move aimed at broadening the applications of
genomic information in medical research and health care.
In the article describing the work in Molecular Therapy, co-authors Charis Himeda, Takako Jones and Peter Jones highlight the important implications for similar types of genetic diseases: «With increasing evidence that the repeat genome (comprising nearly half the
human genome) plays important roles in gene regulation, additional diseases will likely be found associated with aberrant repetitive
genomic sequences,» they write.
Interface of Genomics Research and
Genomic Medicine Recent advances in DNA sequencing technologies mean that it is now possible to conduct genomic analyses, including analysis of the entire genome of an individual human, that just a few years ago would have been too costly an
Genomic Medicine Recent advances in DNA
sequencing technologies mean that it is now possible to conduct
genomic analyses, including analysis of the entire genome of an individual human, that just a few years ago would have been too costly an
genomic analyses, including analysis of the entire genome of an individual
human, that just a few years ago would have been too costly and slow.
I took these comparative
genomic scans to the next level by writing a computer program to identify DNA
sequences that are conserved in other animals but have changed rapidly in
humans since we evolved from our common ancestor with chimpanzees.
In the latest issue of Philosophical Transactions of the Royal Society B, researchers in the laboratory of Gladstone Investigator Katherine Pollard, PhD, use the latest
sequencing and bioinformatics tools to find
genomic regions that guide the development of
human - specific characteristics.
Designing primers against
genomic DNA to amplify the gRNA targets was challenging because you're limited by the
sequence of the
human genome.
His laboratory has also discovered and characterized a significant number of novel genes contributing to autism and
human neurodevelopmental disorders, and has recently applied whole - genome
sequencing technologies and large - scale
genomics datasets to prenatal detection and interpretation of structural variation in the genome.
This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of
genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in
humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of
sequence variation.
«I was looking to see if I could find
genomic regions where the Altai Neanderthal has
sequences resembling those we see in
humans,» says Martin Kuhlwilm.
He played a vital role in annotating the genome
sequences of
human, mouse, chicken and several other organisms; this work has had a profound impact on our understanding of
genomic biology.