Sentences with phrase «human germ lines»

So far, preventing disease by employing CRISPR — Cas9 to alter the human germ line — a human embryo, egg or sperm — has remained extremely controversial, due to concerns about unwittingly introducing errors or leaving stowaway unedited disease - causing mutations that would put future generations at risk of disease.

Furthermore, there is very limited similarity to the human germ line V gene VH1 - 2 * 02 precursor of the VRC01 - like broadly neutralizing antibodies isolated from multiple patients.

Because changing the human germ line is perceived to hold far - reaching consequences, the leading scientific academies of the United States, Britain and China issued a joint statement in December asking researchers around the world to hold off on altering human inheritance.

Not exact matches

I think the next great question humans will face is whether to proceed with germ - line engineering — with designer babies.

It will make Britain the first country in human history to legalise germ - line genetic modification.

«I'm not categorically against all human germ - line editing,» Doudna says, «but I think there would need to be a reason to do it that would justify the risks and costs.»

Dr. Frankel is currently directing or co-directing projects related to the ethical and policy implications of human germ - line interventions, the responsible use of animals in biomedical and behavioral research, improving patient safety and reducing errors in health care, the ethical dimensions of the Human Genome Diversity Project, the uses of anonymity on the Internet, and intellectual property and ethical standards for electronic publishing in scihuman germ - line interventions, the responsible use of animals in biomedical and behavioral research, improving patient safety and reducing errors in health care, the ethical dimensions of the Human Genome Diversity Project, the uses of anonymity on the Internet, and intellectual property and ethical standards for electronic publishing in sciHuman Genome Diversity Project, the uses of anonymity on the Internet, and intellectual property and ethical standards for electronic publishing in science.

29 GENETICALLY MODIFIED SUPERHUMANS The debate over human germ - line engineering — reworking genes in the sperm and egg to create inheritable new traits — sputtered out early in the last decade after gene therapy had a series of notable failures.

«This is an important and fundamental paper for understanding human germ - line cells and finding the basic information about human germ - cell biology,» says reproductive biologist Evelyn Telfer of the University of Edinburgh, UK.

The theory: Millions of years ago, an ancient human ancestor contracted a retrovirus that inserted its DNA into the host's reproductive germ cells, passing the viral DNA down the ancestral line.

Maternal age effect and severe germ - line bottleneck in the inheritance of human mitochondrial DNA Rebolledo - Jaramillo, B., M. S. Su, N. Stoler, J. A. McElhoe et al. 2014.

Establishment of a human embryonic germ cell line and comparison with mouse and human embryonic stem cells.

Maternal age effect and severe germ - line bottleneck in the inheritance of human mitochondrial DNA.

Great Britain's Human Fertilisation and Embryology Authority (HFEA), which oversees fertility treatments and embryo research in that nation, recently approved fertility procedures that would amount to the genetic engineering of children through cloning (nuclear transfer) technology and germ - line modification, resulting in a «three - parent embryo» that would have genetic material from two mothers and one father.

Human Haploid Cells Differentiated from Meiotic Competent Clonal Germ Cell Lines That Originated from Embryonic Stem Cells.

Published in Human Molecular Genetics Ghiorzo P, Gargiulo S, Pastorino L, Nasti S, Cusano R, Bruno W, Gliori S, Sertoli MR, Burroni A, Savarino V, Gensini F, Sestini R, Queirolo P, Goldstein AM, Scarrà GB.Impact of E27X, a novel CDKN2A germ line mutation, on p16 and p14ARF expression in Italian melanoma families displaying pancreatic cancer and neuroblastoma Hum Mol Genet.

This is at the lower end of exome mutation rates previously estimated in parent - offspring trios, suggesting that post-zygotic mutations contribute little to the human germ - line mutation rate.

In addition to the wheat germ lectin, wheat contains gluten, which can bite into the human intestinal mucous lining much like lectins.