Sentences with phrase «human germline»
The phrase "human germline" refers to the genetic information that is passed down from one generation to another. It includes the DNA found in sperm cells of males and egg cells of females. These cells carry the instructions for how a new individual will develop and inherit traits from their parents. Full definition
The future clinical application of human germline genome editing should not proceed unless, at a minimum, there is (a) a compelling medical rationale, (b) an evidence base that supports its clinical use, (c) an ethical justification, and (d) a transparent public process to solicit and incorporate stakeholder input.
ashg.org
So far, the U.S. government hasn't funded research on human germline modification, and other governments have banned it, so we'll talk about somatic cells [sources: Baruch, Hanna].
Its participants released a statement concluding that it would be «irresponsible» for researchers to move forward with clinical human germline editing until its risks and benefits were better known, and there was «broad societal consensus» on its use.
His other recent books include «Transhumanism and Transcendence: Christian Hope in an Age of Technological Transcendence» and «Design and Destiny: Jewish and Christian Perspectives on Human Germline Modification.»
If this claim holds up, Mitalipov will have taken a crucial step forward in the possibility of human germline engineering.
«This report is the first case of human germline genetic modification resulting in normal healthy children,» say Barritt and his colleagues in the journal Human Reproduction.
However, they remain supportive of basic CRISPR research on animals and non-embryonic human cells to see if human germline gene therapy might be helpful in the future to fix genetic mutations.
Parental influence on human germline de novo mutations in 1,548 trios from Iceland Jonsson H et al Nature 2017 Sept 20.
Tina Hesman Saey covered researchers» arguments for and against this type of genetic engineering in «Editing human germline cells debated» (SN: 5/30/15, p. 16).
Now the precision and efficiency of CRISPR has reopened the debate about human germline engineering.
Further, we have a keen interest in developing innovative methods for antibody modeling and design (Willis, J.; et al.; «Human germline antibody gene segments encode polyspecific antibodies»; PLoS Comput Biol; 2013; 9; 100304).
Recent calls for a moratorium on any such research to allow time for expert and public consideration of what is and is not ethically, socially and indeed legally acceptable with respect to human germline genetic modification should definitely be heeded.»
«Parental influence on human germline de novo mutations in 1,548 trios from Iceland» is published today in the online edition of Nature.
A panel of ethicists convened by the U.S. National Academies of Medicine and Science also staked out that position in February, ruling that human germline engineering might someday be permissible for correcting diseases, but only if there are no alternatives and not for enhancements.
«We believe that this type of multi-stakeholder discussion is necessary before proceeding, given the significant issues and concerns related to human germline genome editing,» he said.
It's really a pretty dramatic shift from the existing and widespread agreement globally that human germline editing should be prohibited,» says Marcy Darnovsky, executive director of the Center for Genetics and Society in Berkeley, California.
The wonderful Sharon Begley at STAT has a nice piece on the possible danger of this technique — beyond, of course, the obvious risks and ethical dilemmas of bioterrorism, embryo engineering, and mucking with the human germline for an eternity.
The Forum on Human Germline Interventions, organized by AAAS, convened a multi-disciplinary group of scientists, ethicists, and theologians to participate in discussions regarding scientific freedom and responsibility issues; the history and status of religious involvement; ethical and theological issues; therapeutic vs. enhancement applications; and setting policy and developing guidelines on human germline research and applications.
In October, a UNESCO bioethics panel recommended a temporary ban on «engineering of the human germline, at least as long as the safety and efficacy of the procedures are not adequately proven».
For many people, the fear of a class of genetically enhanced people is reason enough not to tinker with the DNA of the human germline — eggs, sperm, embryos and the cells that give rise to eggs and sperm.
Technology Review said it stands by its story: «Luhan Yang very clearly revealed to us a plan to edit cells of the human germline.
It «painted a picture of her working on a human germline project, when she had just been learning about human oocytes» for the pig genome engineering.
Scientists and the public are now considering the ethics of a tool that might be used someday to edit the genes in the human germline (eggs and sperm) to create new characteristics that could be passed on to subsequent generations, or to correct diseased or otherwise «unwanted» genes.
The MDC researchers are fascinated by the new opportunities the CRISPR - Cas9 system offers for biomedical research, but strictly reject genetic modification of the human germline.
Although manipulation of the human germline is prohibited by law in many countries, including Germany, a global ban is not in effect.
And the international summit saw many discussions of CRISPR's promise for repairing genetic defects in human embryos, if society dares to cross what many regard as an ethical threshold and alter the human germline.
It's become too late to ask whether or not we should edit the human germline; we can now only ask how the experiments will proceed.
Baruch, Susannah et al. «Human Germline Genetic Modification: Issues and Options for Policymakers.»
«No researcher should have the moral warrant to flout the globally widespread policy agreement against modifying the human germline,» Marcy Darnovsky of the Center for Genetics and Society, a watchdog group, wrote in an email to Shots.
«The study simply underscores the point that the technology is not ready for clinical application in the human germline,» Jennifer Doudna, the University of California, Berkeley, scientist who developed CRISPR, wrote in an email.