Sentences with phrase «human glioblastomas»

Glioblastomas in lab dishes and mouse brains are fakes, little Potemkin villages that everyone thought were faithful replicas of human glioblastomas but which, lacking tumor stem cells, were nothing of the kind.

The team found that exposing samples of human glioblastoma tumours grown in a dish to the Zika virus destroyed the cancer stem cells.

In a series of experiments, the researchers first identified a set of 19 transcription factors that were expressed at significantly greater levels in cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cells.

An initial library of 15 biodegradable particle formulations was tested for their ability to carry siRNAs into human glioblastoma cells that were genetically engineered to make green fluorescent protein (GFP).

VIRUS VICTORY Zika virus (green) infects and kills stem cells (red) in human glioblastoma tissue, without infecting healthy brain cells.

Dr. Iavarone's paper is titled, «Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma.»

Therapeutic efficacy of aldoxorubicin in an intracranial xenograft mouse model of human glioblastoma.

Figure 2: Abnormal accumulation of the FGFR - TACC fusion protein (red) in glioblastoma stem cells isolated from a primary human glioblastoma with fused FGFR - TACC genes.

Son et al., SSEA - 1 is an enrichment marker for tumor - initiating cells in human glioblastoma.

Anticancer effects of niclosamide in human glioblastoma.

Human glioblastoma cell line.

Comprehensive genomic characterization defines human glioblastoma genes and core pathways Nature, 455 (7216), 1061 - 1068 DOI: 10.1038 / nature07385

Calorie restriction has been used effectively to treat malignant glioblastoma multiforme in mice, which shares many characteristics with human glioblastoma multiforme, the most aggressive and invasive primary human brain cancer [3].

Not exact matches

In human cells and in mice, the virus infected and killed the stem cells that become a glioblastoma, an aggressive brain tumor, but left healthy brain cells alone.

Using human - derived glioblastoma cells in a mouse models, researchers found that the modified high - fat, low - carbohydrate diet increased life expectancy by 50 percent while also reducing tumor progression by a similar amount.

The investigators report that trapping virus - loaded stem cells in a gel and applying them to tumors significantly improved survival in mice with glioblastoma multiforme, the most common brain tumor in human adults and also the most difficult to treat.

Shah and his team loaded the herpes virus into human MSCs and injected the cells into glioblastoma tumors developed in mice.

Several studies have supported a role for cancer stem cells in the aggressive brain tumors called glioblastoma, but those studies involved inducing human tumors to grow in mice, and as such their relevance to cancer in humans has been questioned.

This new generation of viruses has been genetically «targeted and armed,» says Winald Gerritsen of the VU University Medical Center in Amsterdam, who is involved in an early human trial of an engineered adeno - associated virus that attacks glioblastoma, an aggressive form of brain cancer.

Another is that the transplanted bits of tumor act nothing like cancers in actual human brains, Fine and colleagues reported in 2006: Real - life glioblastomas grow and spread and resist treatment because they contain what are called tumor stem cells, but tumor stem cells don't grow well in the lab, so they don't get transplanted into those mouse brains.

Shah next plans to rationally combine the toxin - secreting stem cells with a number of different therapeutic stem cells developed by his team to further enhance their positive results in mouse models of glioblastoma, the most common brain tumor in human adults.

Into the cerebral cortex of mice with these light - sensitive proteins, the team implanted cancer cells from a human pediatric cortical glioblastoma.

It is a continuation of previous research, published in 2011, that focused on the effect of decitabine on glioblastoma human cell cultures.

Glioblastoma, also known as grade IV glioma, is the most aggressive primary brain tumor in humans.

Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have discovered a peripheral biomarker in human blood serum that can be used to detect the presence and progress of glioblastoma brain tumors before and after treatment.

Our group established that pediatric Glioblastoma Multiforme (GBM), which is one of the deadliest cancers in humans, are molecularly and genetically distinct from adult GBM.

These results could pave the way for the use of progesterone against glioblastoma in a human clinical trial, perhaps in combination with standard - of - care therapeutic agents such as temozolomide.

Research Interests: inflammation; atherosclerosis; glioblastoma; innate immunity; human monocyte / macrophages; lipoxygenase; chemotaxis; superoxide anion; signal transduction; gene expression

In another study, 11 human cancer cell lines (carcinomas and glioblastomas) were exposed to ascorbic acid in which 55 % of the cell lines were more susceptible (EC50 ≤ 20 mmol / L) and 45 % were more resistant (EC50 > 20 mmol / L) to incubation.

Dogs and humans share a particularly deadly form of brain cancer: glioblastoma.

A new five - year canine cancer research project, led by Dr. Liz Pluhar, may improve survival rates in dogs and give researchers more insight into glioblastoma to apply to human trials.