Sentences with phrase «human heart development»

Using cells donated by a family with the mutation, the researchers gained insight into congenital heart disease, human heart development, and healthy heart function.

Dr. Bruce Conklin and colleagues from Gladstone and UC Berkeley grew beating heart tissue from stem cells, creating a model of early human heart development.

Not exact matches

According to the University of Maryland Medical Center polyunsaturated fatty acids (PUFAs)-- also known as omega - 3 fatty acids — play a crucial role in human brain function, as well as normal growth and development, with research showing that they can also reduce inflammation in addition to helping lower the risk of chronic diseases such as heart disease, cancer, and arthritis.

The study drew data from the Pregnancy Outcomes and Community Health (POUCH) and POUCHmoms studies, which were funded by the National Institute of Child Health and Human Development and the National Heart, Lung, and Blood Institute.

In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.

Funding for this study was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development; the National Heart, Lung, and Blood Institute; the American Thoracic Society / American Lung Association Partner Grant; and the Respiratory Health Association.

They add: «What is similar between now and then is the human genetic material, our genome, including ancient polymorphisms that were uncovered to predispose the carrier to the development of atherosclerotic cardiovascular disease... however, our ancient ancestors were certainly susceptible to many other conditions, such as infectious diseases, nutritional deprivation, and trauma, which often resulted in death at an early age, before atherosclerotic heart disease had a clinical impact.»

«Our focus here has been on early heart development, but the basic principles of patterning of human pluripotent stem cells, and subsequently differentiating them, can be readily expanded into a broad range of tissues for understanding embryogenesis and tissue morphogenesis,» said Healy.

«Taken together, these two studies suggest that the new scalable vaccine formulation is likely to prove as effective as the original formulation — which would make it the first protective TB vaccine in humans since BCG, which was introduced almost a century ago,» said Professor Ajit Lalvani, Director of the Tuberculosis Research Centre, National Heart and Lung Institute, Imperial College London and a member of the DAR - 901 development team.

To investigate this question, Ganga Karunamuni of Case Western University and her colleagues studied heart formation in quail embryos, whose heart development is very similar to that of humans.

Launched in 1972, the Dunedin Multidisciplinary Health and Development Study is as fundamental to human development as the Framingham Heart Study is to cardiovascular disease and the Nurses» Health Study is to womeDevelopment Study is as fundamental to human development as the Framingham Heart Study is to cardiovascular disease and the Nurses» Health Study is to womedevelopment as the Framingham Heart Study is to cardiovascular disease and the Nurses» Health Study is to women's health.

This work was supported in part by grants from the US National Institute of Neurological Disorders and Stroke (R01NS058529), the National Human Genome Research Institute (U54HG003273), a joint NHGRI / National Heart Blood and Lung Institute grant (U54HG006542) to the Baylor Hopkins Center for Mendelian Genomics, and the BCM Intellectual and Developmental Disabilities Research Center, IDDRC Grant Number 5P30HD024064 - 23, from the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

«As interest in space travel grows — for both research and commercial aims — it is increasingly important to understand the effect a microgravity environment can have on the human heart for both the traveler and their potential future children,» said Karen Ocorr, Ph.D., assistant professor of the Development, Aging and Regeneration Program at SBP.

«Our focus here has been on early heart development, but the basic principles of patterning of human pluripotent stem cells, and subsequently differentiating them, can be readily expanded into a broad range of tissues for understanding embryogenesis and tissue morphogenesis,» said Dr. Healy.

The 19 NIH institutes, centers and offices contributing to the Knockout Mouse Project are: the NIH Office of Strategic Coordination / Common Fund; NCRR; the National Eye Institute; NHGRI; the National Institute of Allergy and Infectious Diseases; the National Heart, Lung and Blood Institute; the National Institute on Aging; the National Institute of Alcohol Abuse and Alcoholism; the National Institute of Arthritis and Musculoskeletal and Skin Diseases; the Eunice Kennedy Shriver National Institute of Child Health and Human Development; NIDCD; the National Institute of Dental and Craniofacial Research; the National Institute of Environmental Health Sciences; the National Institute of General Medical Sciences; the National Institute of Mental Health; the National Institute of Neurological Disorders and Stroke; the National Institute of Diabetes and Digestive and Kidney Diseases; the National Cancer Institute; and the Office of AIDS Research.

The 19 NIH institutes, centers and offices contributing to the contracts are: National Center for Complementary and Alternative Medicine, National Center for Research Resources, National Eye Institute, National Human Genome Research Institute, National Heart, Lung and Blood Institute, National Institute on Aging, National Institute of Alcohol Abuse and Alcoholism, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Child Health and Human Development, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Institute on Drug Abuse, National Institute of Environmental Health Sciences, National Institute of General Medical Sciences, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute of Nursing Research, and the Office of AIDS Research.

Funding was provided by the Roddenberry Foundation, National Institutes of Health, National Heart, Lung, and Blood Institute, National Eye Institute, National Institute of Child Health and Human Development, National Institute of Mental Health, California Institute of Regenerative Medicine, Prostate Cancer Foundation, and the Leona M. & Harry B. Helmsley Charitable Trust.

«Discovery of a gene that could convert human embryonic stem cells into myocardial cells would be golden,» said Didier Stainier, PhD, UCSF assistant professor of biochemistry and biophysics, the senior author of the UCSF study and a pioneer in the study of heart development in the transparent zebrafish embryo.

The Ukrainian institutions involved in the project are: Open International University of Human Development «Ukraine», Institute of Genetic and Regenerative Medicine of the National Academy of Medical Sciences of Ukraine, Kyiv City Heart Center, Institute of Cell Therapy.

For example, dogs were vital to the development of angioplasty as a treatment or preventive measure for heart attacks and other heart conditions in humans.

«Humans have very limited capacity for regeneration, while other species like salamanders have the remarkable ability to functionally regenerate limbs, heart tissue and even the spinal cord after injury,» said lead researcher Karen Echeverri, PhD, assistant professor in the department of genetics, cell biology and development at the University of Minnesota.

Saiyong Zhu, PhD, Shaohua Xu, PhD, Tao Xu, PhD, Yu Zhang, PhD, and Tianhua Ma, PhD also participated in this research at Gladstone, which was supported by the Roddenberry Foundation, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Energy Institute, the National Heart, Lung and Blood Institute, the National Institute of Mental Health / National Institutes of Health, the California Institute for Regenerative Medicine, the United States Department of Defense and the William K. Bowes, Jr..

The Swedish part of the effort, called the Human Developmental Cell Atlas (HDCA) program, includes researchers from Karolinska Institutet, Stockholm University and KTH, focusing on brain, lung, heart and fetal development during the first 12 -LSB-...]

Funding was provided by the National Heart, Lung, and Blood Institute, National Institute of Child Health and Human Development, National Institute of Drug Abuse, National Institute of General Medical Sciences, California Institute for Regenerative Medicine, Howard Hughes Medical Institute, Canadian Institutes of Health Research, Agilent University Relations, Uehara Memorial Foundation Research, and the UCSF - Gladstone Center for AIDS Research.

Funding was provided by the National Institute of Child Health and Human Development, National Heart, Lung, and Blood Institute, National Eye Institute, California Institute of Regenerative Medicine, National Basic Research Program of China, Chinese Academy of Sciences, and Science and Technology Planning Project of Guangdong Province.

PRDM16 has not previously been associated with cardiac disease but is localized in the nuclei of cardiomyocytes throughout murine and human development and in the adult heart.

Development of a comprehensive system which can enrich hPSC - CMs will be ultimately useful for cell therapy for diseased hearts, human cardiac disease modeling, cardiac toxicity screening, and cardiac tissue engineering.

Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.96

We use the zebrafish model to identify genes and mechanisms that regulate normal heart development, function and regeneration, and that can contribute to cardiac diseases in humans.

The research lines of the Bakkers group include unraveling the genetics of normal cardiac development and body axis formation during development, investigating the molecular mechanisms of heart regeneration in the zebrafish and how this can be compared to heart injury in the mammals, and modeling of human (cardiac) disease in the zebrafish to unravel biological mechanisms behind the disease and to identify new drug targets.

1) Phytonutrients: * Occur naturally in fruits and vegetables * Promote the function of the immune system * Help fight off viruses as well as reduce inflammation * Associated with the treatment and / or prevention of cancer and cardiovascular disease 2) Enzymes: * Responsible for metabolic processes that occur within a cell and are necessary for sustaining life * Assist and play a large role in digestion, energy production, blood coagulation and contraction of muscles 3) Amino Acids: * The basic building blocks of protein * Absorption of amino acids is essential for your metabolism 4) Essential Fatty Acids: * Reduce the risk of heart disease and some forms of cancer * Improve mood * Decrease inflammation 5) Vitamins: * Essential for the normal growth and development of all human beings * Healthy maintenance of cell tissues and organs * Help process proteins, carbohydrates and fats required for utilization 6 & 7) Macro and Trace Minerals: * Involved in electrolyte balance of body fluids * Essential for normal cellular activity * Provide hardness to bones and teeth

A combination of limited human data and a wealth of animal studies show that phthalates, as only one of many chemicals in fragrances, can impair reproduction and development, alter liver and kidney function, damage the heart and lungs, and effect blood clotting.

In indigenous Australians and Papua New Guineans, mingling with the Denisovans (the «other Neanderthal,» an ancestral human living primarily in Asia) introduced genes related to «spermatogenesis, fertilization, cold acclimation, circadian rhythm, development of brain, neural tube, face, and olfactory pit, immunity,» as well as «female pregnancy, development of face, lung, heart, skin, nervous system, and male gonad, visual and smell perception, response to heat, pain, hypoxia, and UV, lipid transport, metabolism, blood coagulation, wound healing, aging.»

As chieftain, the Panther is entitled to eat a special heart - shaped herb which, in addition to his mystical connection with the Wakandan Panther god, grants him superhumanly acute senses and increases his strength, speed, stamina, and agility to the peak of human development.

As chieftain, the Panther is entitled to eat a special heart - shaped herb, as well as his mystical connection with the Wakandan Panther God, that grants him superhumanly acute senses (especially eyesight, night vision, and sense of smell) and increases his strength, speed, stamina, and agility to the peak of human development.

The development of the game will be going to Human Heart Studios, which was the original development team of the original Prey.

Founded in 2012, the Humanities and Liberal Arts Assessment project (HULA) research team has taken on the project of understanding the learning theories and related theories of human development that lie at the heart of the humanities.

The outcome statement of the Rio +20 Conference on Sustainable Development (2012) centred around ecological sustainability.2 If countries of the world are serious about the commitment made at Rio, then the MDGs need to evolve into a new framework; sustainability was not at their heart, and it is increasingly clear that without such an orientation, various «development» goals are impossible to meet for both the current and future generations.3 As the report of the UN System Task Team on the post-2015 development agenda says, «the proposed vision and framework for the post-2015 agenda must be fully aligned with that (Rio +20) outcome».4 Accordingly, the theme of sustainability should be running through all the post-2015 goals (as should the themes on equity and human rights), even as more specific environmental targets such as halting the erosion of biodiversity could be specified in one ofDevelopment (2012) centred around ecological sustainability.2 If countries of the world are serious about the commitment made at Rio, then the MDGs need to evolve into a new framework; sustainability was not at their heart, and it is increasingly clear that without such an orientation, various «development» goals are impossible to meet for both the current and future generations.3 As the report of the UN System Task Team on the post-2015 development agenda says, «the proposed vision and framework for the post-2015 agenda must be fully aligned with that (Rio +20) outcome».4 Accordingly, the theme of sustainability should be running through all the post-2015 goals (as should the themes on equity and human rights), even as more specific environmental targets such as halting the erosion of biodiversity could be specified in one ofdevelopment» goals are impossible to meet for both the current and future generations.3 As the report of the UN System Task Team on the post-2015 development agenda says, «the proposed vision and framework for the post-2015 agenda must be fully aligned with that (Rio +20) outcome».4 Accordingly, the theme of sustainability should be running through all the post-2015 goals (as should the themes on equity and human rights), even as more specific environmental targets such as halting the erosion of biodiversity could be specified in one ofdevelopment agenda says, «the proposed vision and framework for the post-2015 agenda must be fully aligned with that (Rio +20) outcome».4 Accordingly, the theme of sustainability should be running through all the post-2015 goals (as should the themes on equity and human rights), even as more specific environmental targets such as halting the erosion of biodiversity could be specified in one of the goals.

Research in humans shows that untreated periodontal disease is a key factor in the development of heart, liver and kidney problems and is a source of chronic low - grade infection.

The Human Animal Bond Research Institute (HABRI) confirms this as well; Bob Vetere, chairman at HABRI and the Pet Leadership Council (PLC), says, «Research has shown that pets support child health and development, promote healthy aging, improve heart health, and also help families dealing with cancer, autism and PTSD.»

Sumi Kang formulates a theory that failure is at the heart of the development of the human worldview and civilization, which connects to the notion of failure as one of the most significant forces in the history of avant - garde art.

The installation, and accompanying series of public talks, will link together the earliest historical attempts to record and visualize the human pulse and heartbeat — from a record onboard a NASA probe at the edge of the Solar System to recent developments in artificial heart research.

All are damaging to child development in different ways, and sugar wreaks havoc on the human body in ways that science is just beginning to understand — from overtaxing the liver (just like alcohol) to triggering serious chronic illnesses, such as diabetes and heart disease.

I found that by integrating the structures of family law and family psychology, and by applying the tenets of human development with a compassionate and caring heart, I can do the most good.

In this workshop Robin will discuss and consider the explosion of scientific research around the world in child development, emotional intelligence, brain development and the human heart, including the key childhood experiences that promote children's emotional intelligence.