Sentences with phrase «human hematopoietic»

One postdoctoral position is available in the Human hematopoietic development and disease modeling unit, headed by Andrea Ditadi at SR - Tiget

Zonari E, Desantis G, Petrillo C, Boccalatte FE, Lidonnici MR, Kajaste - Rudnitski A, Aiuti A, Ferrari G, Naldini L, Gentner B. Efficient ex vivo engineering and expansion of highly purified human hematopoietic stem and progenitor cell populations for gene therapy.

Kronenwett et al. «Oligodeoxyribonucleotide Uptake in Primary Human Hematopoietic Cells Is Enhanced by Cationic Lipids and Depends on the Hematopoietic Cell Subset», Blood, 91 (3): 852 - 862, 1998.

Dr. Péault is internationally recognized principally for his work on the prospective identification and characterization of human hematopoietic (blood) stem cells, of which his laboratory has also deciphered the ultimate origin during embryonic life.

Basso - Ricci L, Scala S, Milani R, Migliavacca M, Rovelli A, Bernardo ME, Ciceri F, Aiuti A, Biasco L. Multiparametric Whole Blood Dissection: A one - shot comprehensive picture of the human hematopoietic system.

Review of «Safety and efficacy of a tCD25 pre-selective combination anti-HIV lentiviral vector in human hematopoietic stem and progenitor cells» from Stem Cells by Stuart P. Atkinson

Recent papers published by groups from UC Berkeley and Stanford University have described methods for the genetic manipulation of primary human hematopoietic stem and progenitor cells (HSPCs) that require them to be maintained in vitro for anywhere from 24 hours to more than a week.

In order to modify or expand primary human hematopoietic cells, they must first be isolated from the body and then cultured under conditions that allow for their modification.

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self - renewal.

HSV - sr39TK positron emission tomography and suicide gene elimination of human hematopoietic stem cells and their progeny in humanized mice.

A detailed comparison of gene expression signatures between ETP ALL tumors and and normal human hematopoietic progenitor cells revealed a somewhat surprising finding: ETP - ALL expression patterns were less consistent with early T - cell precursors, as might have been expected, but more similar to the expression profile of normal hematopoietic stem cells and granulocyte macrophage precursors.

Ana Fonseca (Corbeil, TUD)-- «New insights into cell migration and asymmetric cell division of human hematopoietic progenitors» (2008)

Since her recruitment at SR - Tiget as an independent Project Leader in 2012, promoted to Group Leader in 2016, her team investigates the molecular mechanisms of host - vector interplay during gene transfer in human hematopoietic stem cells (HSC).

Zhao and his colleagues are also investigating whether a megakaryocyte niche can be used to help expand human hematopoietic stem cells in vitro and stem cell transplantation for patients.

The transplantation of isolated human hematopoietic stem cells is used in the treatment of anemia, immune deficiencies and other diseases, including cancer.

Human hematopoietic stem and progenitor cells (HSPCs), derived from bone marrow, have become a primary vehicle for efforts to replace or regenerate cells destroyed by a variety of diseases.

For now, Porteus and his team found that their corrected human hematopoietic stem cells seemed to behave like normal, healthy human hematopoietic stem cells.

Not exact matches

Hematopoietic stem cells, that form mature blood cells, require a very precise amount of protein to function — and defective regulation of protein production is common in certain types of aggressive human blood cancers.

Meanwhile, recent human studies indicate that aging is associated with an increase in somatic mutations in the hematopoietic system, which gives rise to blood cells; these mutations provide a competitive growth advantage to the mutant hematopoietic cells, allowing for their clonal expansion — a process that has been shown to be associated with a greater incidence of atherosclerosis, though specifically how remains unclear.

Beilhack and colleagues found that a slightly modified version of STAR2 has a similar effect on human T reg cells, suggesting that the approach could also prevent GvHD in leukemia and lymphoma patients after bone marrow or hematopoietic stem cell transplants.

Following introduction into human CD4 + T cells [23] or hematopoietic stem cells [28] via an adenovirus vector or DNA nucleofection, respectively, the ccr5 gene was efficiently and specifically disrupted.

P, Schiroli G, Escobar G, Di Tomaso T, Firrito C, Calabria A, Moi D, Mazzieri R, Bonini C, Holmes MC, Gregory PD, van der Burg M, Gentner B, Montini E, Lombardo A, Naldini L. Targeted genome editing in human repopulating hematopoietic stem cells.

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.

Human immunodeficiency virus (HIV) can infect bone marrow cells — including, possibly, hematopoietic stem cells, according to a study published online today (March 7) in Nature Medicine.

Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells.

Cytokinesis failure occurs in Fanconi anemia pathway — deficient murine and human bone marrow hematopoietic cells.

Forced aggregation of defined numbers of human embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation.

In Lifemap, the HaemAtlas dataset provides gene expression for adult human B cells, helper T cells, natural killer cells, granulocytes, and monocytes while the Hematopoietic Fingerprints dataset provides gene expression information for postnatal stem cells and their progeny.

While human cord blood represents a potentially important source of hematopoietic stem and progenitor cells (HSPC), current two dimensional (2D) growth conditions employed to amplify cell numbers to the level required for many regenerative applications lead to a decline in the absolute percentage of the most primitive HSPCs [1].

Kim Y - S, Wielgosz M, Hargrove P, Kepes S, Gray J, Persons D, Nienhuis A. Transduction of Human Primitive Repopulating Hematopoietic Cells with Lentiviral Vectors Pseudotyped with Various Envelope Proteins.

Targeted Gene Addition to a Safe Harbor locus in human CD34 + Hematopoietic Stem Cells for Correction of X-linked Chronic Granulomatous Disease.

High level erythroid lineage - directed gene expression using globin gene regulatory elements following lentiviral vector mediated gene transfer into primitive human and murine hematopoietic cells.

Selection - free genome editing of the sickle mutation in human adult hematopoietic stem / progenitor cells.

Human MSCs are defined by positive expression of the cell surface antigens CD73, CD90, CD105 and by absence of expression of hematopoietic antigens, including CD11b or CD14, CD34, CD45, CD79 or CD19, and HLA - DR.

Lentiviral - based gene therapy methods to modify human CD34 + hematopoietic stem cells have been investigated as a way of treating various hematological disorders including X-linked chronic granulomatous disease (X-CGD).

Professor Kyurkchiev's group is currently developing a project on the controlled differentiation of human induced pluripotent stem cells into hematopoietic stem cells and lymphoid cells.

We discovered that CD45 does not colocalize with lipid rafts on murine and human non-transformed hematopoietic cells.

The human chorion contains definitive hematopoietic stem cells from the fifteenth week of gestation.

He is the principal investigator of an NCI - funded, multi-million-dollar Specialized Program of Research Excellence (SPORE) in ovarian cancer, and he is the principal investigator of a multi-million-dollar grant from the New York State Stem Cell Science program (NYSTEM) to pioneer a novel strategy of reprogramming human mature T cells and hematopoietic stem cells for generating sustained attack against ovarian cancer in patients.

Guido Silvestri, MD, division chief of Microbiology and Immunology at the Yerkes Research Center at Emory, and several of his research colleagues performed the first hematopoietic stem cell transplantation in three rhesus macaques infected with a simian human immunodeficiency virus (SHIV).

A new role for the human placenta as a hematopoietic site throughout gestation.

Human placenta and chorion: potential additional sources of hematopoietic stem cells for transplantation.

The team of researchers harvested hematopoietic stem cells from three macaques prior to SHIV infection of all six animals in the study, treated the animals with anti-retroviral therapy (ART) to reduce viral load and mimic the situation in human HIV - infected patients who are treated with ART, and then exposed the three monkeys from which they had collected hematopoietic stem cells to a high dose of radiation.

A quantitative assessment of the content of hematopoietic stem cells in mouse and human endosteal - bone marrow: a simple and rapid method for the isolation of mouse central bone marrow.

Shier LR, Schultz KR, Imren S, Regan J, Issekutz A, Sadek I, Gilman A, Panzarella T, Eaves CJ, Couban S. Differential Effects of G - CSF on Marrow and Blood - Derived Hematopoietic and Immune Cell Populations in Healthy Human Donors.

While Wang et al. [12] recently showed no expansion advantage of hematopoietic cells derived from human ES cells, Bowles and colleagues [13] saw increased expansion.

Laboratory model of immune system overcomes ethical constraints on studies of hematopoietic stem cells in humans.