Zhao and his colleagues are also investigating whether a megakaryocyte niche can be used to help expand
human hematopoietic stem cells in vitro and stem cell transplantation for patients.
Not exact matches
Hematopoietic stem cells, that form mature blood
cells, require a very precise amount of protein to function — and defective regulation of protein production is common
in certain types of aggressive
human blood cancers.
The transplantation of isolated
human hematopoietic stem cells is used
in the treatment of anemia, immune deficiencies and other diseases, including cancer.
Beilhack and colleagues found that a slightly modified version of STAR2 has a similar effect on
human T reg
cells, suggesting that the approach could also prevent GvHD
in leukemia and lymphoma patients after bone marrow or
hematopoietic stem cell transplants.
P, Schiroli G, Escobar G, Di Tomaso T, Firrito C, Calabria A, Moi D, Mazzieri R, Bonini C, Holmes MC, Gregory PD, van der Burg M, Gentner B, Montini E, Lombardo A, Naldini L. Targeted genome editing
in human repopulating
hematopoietic stem cells.
Since her recruitment at SR - Tiget as an independent Project Leader
in 2012, promoted to Group Leader
in 2016, her team investigates the molecular mechanisms of host - vector interplay during gene transfer
in human hematopoietic stem cells (HSC).
Human immunodeficiency virus (HIV) can infect bone marrow
cells — including, possibly,
hematopoietic stem cells, according to a study published online today (March 7)
in Nature Medicine.
Expression of the melanoma
cell adhesion molecule
in human mesenchymal stromal
cells regulates proliferation, differentiation, and maintenance of
hematopoietic stem and progenitor
cells.
HSV - sr39TK positron emission tomography and suicide gene elimination of
human hematopoietic stem cells and their progeny
in humanized mice.
In Lifemap, the HaemAtlas dataset provides gene expression for adult
human B
cells, helper T
cells, natural killer
cells, granulocytes, and monocytes while the
Hematopoietic Fingerprints dataset provides gene expression information for postnatal
stem cells and their progeny.
While
human cord blood represents a potentially important source of
hematopoietic stem and progenitor
cells (HSPC), current two dimensional (2D) growth conditions employed to amplify
cell numbers to the level required for many regenerative applications lead to a decline
in the absolute percentage of the most primitive HSPCs [1].
Recent papers published by groups from UC Berkeley and Stanford University have described methods for the genetic manipulation of primary
human hematopoietic stem and progenitor
cells (HSPCs) that require them to be maintained
in vitro for anywhere from 24 hours to more than a week.
Review of «Safety and efficacy of a tCD25 pre-selective combination anti-HIV lentiviral vector
in human hematopoietic stem and progenitor cells» from Stem Cells by Stuart P. Atki
stem and progenitor
cells» from Stem Cells by Stuart P. Atk
cells» from
Stem Cells by Stuart P. Atki
Stem Cells by Stuart P. Atk
Cells by Stuart P. Atkinson
Targeted Gene Addition to a Safe Harbor locus
in human CD34 +
Hematopoietic Stem Cells for Correction of X-linked Chronic Granulomatous Disease.
Selection - free genome editing of the sickle mutation
in human adult
hematopoietic stem / progenitor
cells.
He is the principal investigator of an NCI - funded, multi-million-dollar Specialized Program of Research Excellence (SPORE)
in ovarian cancer, and he is the principal investigator of a multi-million-dollar grant from the New York State
Stem Cell Science program (NYSTEM) to pioneer a novel strategy of reprogramming human mature T cells and hematopoietic stem cells for generating sustained attack against ovarian cancer in patie
Stem Cell Science program (NYSTEM) to pioneer a novel strategy of reprogramming
human mature T
cells and
hematopoietic stem cells for generating sustained attack against ovarian cancer in patie
stem cells for generating sustained attack against ovarian cancer
in patients.
Guido Silvestri, MD, division chief of Microbiology and Immunology at the Yerkes Research Center at Emory, and several of his research colleagues performed the first
hematopoietic stem cell transplantation
in three rhesus macaques infected with a simian
human immunodeficiency virus (SHIV).
The team of researchers harvested
hematopoietic stem cells from three macaques prior to SHIV infection of all six animals
in the study, treated the animals with anti-retroviral therapy (ART) to reduce viral load and mimic the situation
in human HIV - infected patients who are treated with ART, and then exposed the three monkeys from which they had collected
hematopoietic stem cells to a high dose of radiation.
A quantitative assessment of the content of
hematopoietic stem cells in mouse and
human endosteal - bone marrow: a simple and rapid method for the isolation of mouse central bone marrow.
Laboratory model of immune system overcomes ethical constraints on studies of
hematopoietic stem cells in humans.