Sentences with phrase «human immune cells»

By analyzing a dataset of human immune cells stimulated with interferon — a signaling protein created in response to pathogens or tumor cells — the team could precisely identify which genes were switched on in each of 13 responding cell types.

Working with human immune cells in the laboratory, Johns Hopkins researchers report they have identified a critical cellular «off» switch for the inflammatory immune response that contributes to lung - constricting asthma attacks.

The team used the technology to study motions of proteins on the surface of the HIV virus (called envelope proteins) that are key to the virus's ability to infect human immune cells carrying CD4 receptor proteins.

Previous research had established SAMHD1 as a key player in inhibiting HIV replication in human immune cells, piquing his interest.

SAN FRANCISCO, CA — Researchers at the Gladstone Institutes and UC San Francisco (UCSF) have used a newly developed gene - editing system to find gene mutations that make human immune cells resistant to HIV infection.

Researchers at the Gladstone Institutes and UC San Francisco (UCSF) have used a newly developed gene - editing system to find gene mutations that make human immune cells resistant to HIV infection.

Dr. Vijayanand also oversees a large - scale effort to map epigenomic modifications in more than a dozen different types of human immune cells from normal individuals to understand how epigenetic variations cause susceptibility to disease.

Newly - discovered mechanism of action of the bacterial superantigen toxins: Superantigens bind to both B7 - 2 and CD28, the major costimulatory receptors expressed on human immune cells.

Other landmark genetic - altering treatments have also gained traction in recent weeks, including Novartis» cancer therapy which morphs human immune cells into personalized cancer - killers.

In the second Cell paper, researchers collaborated with scientists at the University of Cambridge, McGill University in Canada and several UK and European institutions to explore the role that epigenetics plays in the development and function of three major human immune cell types: CD14 + monocytes, CD16 + neutrophils and naïve CD4 + T cells, from the genomes of 197 individuals.

Engineered human immune cells can vanquish a deadly pediatric brain tumor in a mouse model, a study from the Stanford University School of Medicine has demonstrated.

Human tumor tissue or cell lines can be coengrafted into these mouse models, providing a powerful tool for studying the interactions between human immune cells and human cancers.

Millie Hughes - Fulford, a medical professor at the University of California, San Francisco, US, and her team subjected human immune cells to a device that simulates microgravity.

Lead researcher Ilenia Papa from ANU said the research confirmed for the first time that human immune cells contain particles that have neurotransmitters including dopamine, which plays a crucial role in immune responses.

If RAP does not reach its target molecule, the whole communication process breaks down, toxins do not get made, and human immune cells converge on the now - helpless staph germs, ready to mop them up.

The research team found that Alphamers not only bind strep and recruit anti-Gal antibodies to the bacterial surface, they also helps human immune cells engulf and kill the Alphamer - coated bacteria.

The new system allows researchers to quickly modify the genetic code of freshly donated human immune cells and will hopefully accelerate the quest to finally cure HIV + patients, the researchers said.

For years, Prof. Howell and her team sought a compound that would activate human immune cells called Invariant natural killer T (iNKT) cells.

A Postdoctoral Research Associate Position is available funded by the Wellcome Trust, to study the nanoscale organisation of human immune cell surfaces by super-resolution fluorescence microscopy.

This webinar highlights recent advances and future directions using humanized NSG ™ mice with functional human immune cells, to study human infectious diseases including HIV.

Reishi has been shown to activate several types of human immune cells such as macrophages and natural killer cells.

The mutant far more easily infected human immune cells than did the ancestral pseudotype, the team reports today in Cell.

Knoell's lab was the first to show how the mineral helped control activity of an NF - kappaB protein called IKKbeta in human immune cells, subsequently reducing inflammation and preventing damage to cells.

To replicate, Liotta explains, HIV fuses with human immune cells by interacting with key proteins.

Scientists in the laboratory of Nevan Krogan, PhD, and a team from UCSF developed a new gene - editing platform using CRISPR to make human immune cells resistant to HIV.

Researchers at the Gladstone Institutes and UCSF have used a newly developed gene - editing system to find gene mutations that make human immune cells resistant to HIV infection.

Vijay also oversees a large - scale effort to map epigenomic modifications in more than a dozen different types of human immune cells from normal individuals to understand how epigenetic variations cause susceptibility to disease.

Sub-type B HIV viruses are more likely to lead to the production of antibodies directed against the region of the virus surface through which it binds to human immune cells (CD4 binding site).

In the third animal model, latent HIV - 1 infection was recapitulated in humanized mice engrafted with human immune cells, including T cells, followed by HIV - 1 infection.

They are the first to perform the feat in three different animal models, including a «humanized» model in which mice were transplanted with human immune cells and infected with the virus.

Staphylococcus aureus bacteria (colored green) interacting with a human immune cell.

Johns Hopkins biochemists have figured out what is needed to activate and sustain the virus - fighting activity of an enzyme found in CD4 + T cells, the human immune cells infected by HIV.

They saw HIV - infected human immune cells, caught virus particles in the act of budding from such cells, and also found groups of free immature and mature viruses.

New studies in Nature and Science describe technology that reveals the motions of proteins on the surface of HIV that are key to the virus's ability to infect human immune cells.

Researchers at Weill Cornell Medical College have developed technologies that allow investigators, for the first time, to watch what they call the «dance» of HIV proteins on the virus» surface, which may contribute to how it infects human immune cells.

The researchers modified a type of human immune cell — called T lymphocytes, or T cells — to target a molecule called CS1, which is found on more than 95 percent of myeloma cells, and to kill the cells.

Those same mechanisms allow yeast to evade a type of human immune cell that looks and acts just like an amoeba (similar cells are also found in other animals).

«Now we have the ability to make modifications in human immune cells and right away see the effects.

When EBV infects human immune cells, a protein produced by the virus — EBNA2 — recruits human proteins called transcription factors to bind to regions of both the EBV genome and the cell's own genome.

Subsequently, I'm managing a large - scale, genome - wide study on gene expression and epigenetic markers in various types of human immune cells, which will aid the understanding of epigenetic variations that cause the susceptibility to disease.

Research Focus: I am involved in the analysis of transcriptomic and epigenomic data in various types of human immune cells and in different diseases.

Our studies were performed using mouse and human immune cells and included cell lines, primary cells and expanded primary cells providing robust results.

To improve our understanding and to build better and more translatable in vivo mouse tumor models, we are developing humanized mouse models consisting of the transplant of patient - derived tumor xenografts into immunodeficient mice reconstituted with human immune cells (isolated from the matching patient from the draining LNs or with allogenic PBMCs or LN cells).

• Disease - driving pathways that involve the human immune system are often targeted by antibodies, and Organ - Chips recreate complex interactions of different human cell types and aspects of the human immune system, overcoming limitations of animal models which do not reflect all human immune cells.

Co-engrafting mice with human tumors that retain the same characteristics and human immune cells, is a new platform to study the relationship between the human immune system and tumors and develop immuno - oncology - based cancer therapies.

Dietary supplementation with trans - 11 - and trans -12-18:1 increases cis - 9, trans -11-conjugated linoleic acid in human immune cells, but without effects on biomarkers of immune function and inflammation