Sentences with phrase «human immune response»

Another important feature of this antibody is that it acts on a part of the virus that is not normally targeted by the normal human immune response.

Some of those carbohydrates do actually trigger a mild human immune response.

I am interested in understanding the characteristics of human immune response against infectious agents and the role of HLA molecules.

It is based on the scientific understanding and high - throughput analyses of human immune responses to disease - related proteins in selected populations including elderly with the capability to stay healthy during the aging process.

We will then validate the generalizability of protective human immune responses against Clone 10 and other candidate antigens in an independent cohort of Tanzanian children, and investigate potential single nucleotide polymorphisms in Clone 10 from P. falciparumfield isolates from Tanzania.

Since 18 years, the research focus of the MyTb lab is to characterise and understand human immune responses to Mycobacterium tuberculosis with emphasis on mycobacterial lipids.

His lab has extensive experience evaluating and modulating T cell responses to tumors and viruses, including introducing genes into T cells to impart specificity and modulate function, designing strategies to overcome tolerance and enhance in vivo activity, and developing mouse models that more accurately model human immune responses to candidate vaccines.

Discuss how mouse models can be used to study human immune responses against leukemia (using primary or genetically modified leukemia cells) and melanoma

(PMID: 11279501)[ii] Stamper CC, Zhang Y, Tobin JF, Erbe DV, Ikemizu S, Davis SJ, Stahl ML, Seehra J, Somers WS, Mosyak L. Crystal structure of the B7 - 1 / CTLA - 4 complex that inhibits human immune responses.

He played an important role in the early establishment of MalariaGEN, participating in several consortial projects investigating human immune responses to malaria.

Dr. Anuja Mathew is the newest members of the iCubed team, joining the Institute in August 2015 to research human immune responses to dengue virus infections alongside world renowned Dr. Alan Rothman.

More to the point, by genetically stripping dengue virus of its ability to bind 14 -3-3 epsilon, Gack has generated a crippled virus that can elicit a strong human immune response, providing a framework for rational vaccine design against emerging infectious diseases.

The Scripps Research Institute / IAVIScientists at IAVI's Neutralizing Antibody Center are dedicated to unlocking the secrets of protective human immune responses to HIV and harnessing them to create an AIDS vaccine.

«It will also be interesting to see if this protein interferes with the human immune response,» Myles said.

The paper focuses on two key molecular players in the story of influenza infection: a human protein called TRIM25, which was recently discovered to play an important role in the human immune response to flu infection; and a protein called NS1 present in all strains of the influenza A virus and shown to bind TRIM25 to keep it from doing its job.

The antigen must carry this adjuvant, which acts like a turbocharger for the human immune response.

«Our test would have picked up the risk because it is a skin - based model of the human immune response.»

In further experiments, the team found that antibodies that trigger enhancement dominate the human immune response to the live virus, so people vaccinated with whole dead virus may respond in the same way.

«Ideally your immune system should rebuff these parasites, but they have the ability to suppress the human immune response.

Immunologists have suspected that P. falciparum, the most deadly malaria parasite, uses several mechanisms to evade the human immune response and invade red blood cells.

Stoute's team, along with colleagues at the Walter Reed Army Institute of Research and the PATH Malaria Vaccine Initiative, showed that the parasite uses an arm of the human immune response called the complement system to do so.

Research Focus: My research focuses on genetic variation and its effects on the human immune response, using material from normal human donors.

However, the spikes present new binding sites for the human immune response to infection and as such, may present promising new targets for the development of different types of drugs.

Blocking a factor that can activate the human immune response against intestinal bacteria or certain foods could prevent the development of celiac disease in those most at risk, researchers report in the journal Nature.

PfSEA - 1 was discovered by starting with naturally occurring protective human immune responses.

As a graduate student, I focused on the regulation of denitrification pathway in Pseudomonas aeruginosa and the regulation of iron in the context of breast cancer from a systems biology perspective and had further extrapolations into the human immune response to tuberculosis and microbiome changes due to antibiotic usage from a computational biology perspective.

Meanwhile, Gack's work has also shed light on the mechanisms through which mosquito - borne viruses such as dengue virus and West Nile virus evade the human immune response.

The human immune response to tuberculosis and its treatment: a view from the blood Cliff J.M., Kaufmann S.H.E., McShane H, van Helden P., O'Garra A Immunological Reviews, 2015 264 (1): 88 - 102.

Using these mutants as templates, the researchers attached the genes that code for the surface proteins that trigger the human immune response (and thus offer protection in vaccinated individuals)-- HA (hemagglutinin) and NA (neuraminidase).

Career Goals: I plan to pursue a career in scientific research focused on understanding the human immune response to various infectious agents for diagnostic and vaccine design purpose.

Research Focus: I am currently working both on capacity building in Nepal as well as the human immune response to Zika virus and dengue virus.

He wanted to understand the human immune response's role in cancer and other diseases.

February 9, 2011 Human and mouse studies sharpen focus on cause of celiac disease Blocking a factor that can activate the human immune response against intestinal bacteria or certain foods could prevent the development of celiac disease in those most at risk, researchers report in the journal Nature.

Gut flora influences the human immune response (provides a blockade against damaging bacteria; gives a «safe word» to avoid the immune system wasting resources on attacking; influences size of the thymus).