In stark contrast to contemporary
human influenza H1N1 viruses, the 1918 pandemic virus had the ability to replicate in the absence of trypsin, caused death in mice and embryonated chicken eggs, and displayed a high - growth phenotype in human bronchial epithelial cells.
Not exact matches
Nelson and her colleagues found that flu in pigs «follows long - distance swine movements from the southern U.S. to the Midwest,» with most of the
human - origin
H1N1 arriving at Midwest hog farms coming from the Southeast, and most of the swine - origin H1N2 coming from the south - central U.S. And that means the Midwest, as the final destination for many of these pigs, is «likely to provide a reservoir for multiple genetically distinct variants to co-circulate and exchange segments via re-assortment because of the continual importation of swine
influenza viruses from other regions,» the researchers noted.
Yet a novel strain of the
influenza A (
H1N1) virus jumped species and burst into the
human population in March and April, and by late May health and agriculture officials were still trying to figure out where it came from.
The study, led by Nancy J. Cox of the Centers of Disease Control and Prevention describes a molecular analysis of the novel
influenza A (
H1N1) virus infecting
humans in several parts of the world.
In early 2009, a novel
influenza A (
H1N1) virus appeared in
humans, containing a unique combination of
influenza genes which had not previously been identified in animals or people.
Using virus histochemical analysis, the investigators looked at the pattern of attachment of two genetically engineered emerging H7 viruses (containing the hemagglutinin (HA) of either
influenza virus A / Shanghai / 1 / 13 or A / Anhui / 1 / 13) to fixed
human respiratory tract tissues and compared the findings to attachment patterns seen with
human influenza viruses with high transmissibility but low virulence (seasonal H3N2 and pandemic
H1N1) and highly pathogenic avian
influenza (HPAI) viruses with low transmissibility and high virulence (H5N1 and H7N7).
We have determined that the virus
H1N1 Influenza A found in these pigs is the virus which is being tracked in the
human population.
Unlike flu viruses that affect
humans, the eight
influenza genes in this
H1N1 changed very little for 6 decades.
The vaccines targeted an
influenza A
H1N1 seasonal flu strain as well as A (H7N9), a virus considered to have the potential to trigger a
human pandemic.
All
influenza viruses ultimately come from birds, and the paper begins the somewhat operatic and knotty story of this outbreak's origins with an
H1N1 first isolated in swine in 1930, which itself was a close relative of the virus that caused the 1918 pandemic in
humans.
When they delivered this virus into the noses of mice and ferrets, the animals» epithelial cells produced the desired antibodies; they then «challenged» the animals with a range of dangerous
influenza viruses that no single vaccine can outwit, including H5N1, which kills both birds and
humans, and the
H1N1 that caused the infamous 1918 pandemic.
Unfortunately, we have already seen certain trading partners implement trading restrictions based of the detection of
H1N1 influenza virus in
humans.
The virus, the result of a reassortment of four strains of
influenza A virus subtype
H1N1 (one endemic in
humans, one in birds, and two in pigs), has claimed around a hundred lives and been reported in over 50 countries.
The virus did not appear to spread from
human to
human but once again proved that the triple - reassortant swine
influenzas — a family the novel
H1N1 belongs to — are unusually promiscuous and need to be watched carefully.
At the outset, no one could predict that the novel
H1N1 virus — a recombination of
human, pig, and avian
influenza genes — would turn out to be more wimp than monster.
The never - before - described virus did not involve the novel
H1N1 but instead picked up the surface genes from the seasonal
human H1N1 virus that has long infected
humans and combined them with what's known as the triple - reassortant swine
influenza.
But a new report from Hong Kong, which conducts the world's most comprehensive surveillance of
influenza viruses in pigs, has described the first instance of a swine virus picking up a gene from the novel
H1N1 circulating in
humans.
Chiu pointed to a number of serious and unexpected animal - to -
human disease transmissions over the last 10 years, including SARS in 2003, the
H1N1 influenza in 2009, and the current outbreak of H7N9 avian
influenza, which already has resulted in more than 20 deaths in China.
The
human influenza virus
H1N1 that caused the 2009 flu pandemic, and H9N2, an avian
influenza virus that is endemic in bird populations in Asia, are close cousins — close enough that they can swap genes if they find themselves in the same cell, resulting in new viruses that are a patchwork of the parent strains.
CDC researchers took ferrets never infected with an
influenza virus and injected them with this year's vaccine, which has an
H1N1 component of
human, not swine, origin.
In vivo prophylactic and therapeutic efficacy of
human mAbs against pandemic
H1N1 influenza virus.
Diversity of
Influenza Viruses in Swine and the Emergence of a Novel
Human Pandemic
Influenza A (
H1N1)
Broadly cross-reactive antibodies dominate the
human B cell response against 2009 pandemic
H1N1 influenza virus infection
Pigs are natural hosts for
influenza viruses that can infect
humans, in particular the 2009 and, going way back, 1918
H1N1 flu strains.
Besides H3N2, the two other flu strains causing illness are
H1N1, an
influenza strain that caused the 2009 - 2010 swine flu pandemic but is now a regular
human flu virus, and an
influenza B strain.
Her first major discovery, in 2006, identified a loop in the nucleoprotein of the
H1N1 human influenza virus.
Howard Hughes Medical Institute researchers have identified a naturally occurring
human protein that helps prevent infection by
H1N1 influenza and other viruses, including West Nile and dengue virus...
Tsibane T, Ekiert DC, Krause JC, Martinez O, Crowe JE, Wilson IA, Basler CF.
Influenza human monoclonal antibody 1F1 interacts with three major antigenic sites and residues mediating
human receptor specificity in
H1N1 viruses.
This strain of the
H1N1 influenza virus has also been found in birds, ferrets, pigs, and a dog, in addition to
humans and cats.
The
H1N1 influenza virus that was involved in the
human pandemic of 2009 can also infect cats but cats do not shed virus back in amounts likely to infect
humans.