The experimental vaccine, described in next month's Nature Biotechnology, could lead to
a human influenza vaccine that uses up to 1000 times less DNA than current experimental vaccines.
Not exact matches
In Canada,
vaccines prevent illnesses such as diphtheria, tetanus, pertussis (whooping cough), polio, Haemophilus
influenzae type B (Hib), rotavirus, hepatitis B, measles, mumps, rubella, chickenpox, pneumococcal and meningococcal diseases, and
human papillomavirus virus (HPV).
Currently, seasonal flu
vaccines are designed to induce high levels of protective antibodies against hemagglutinin (HA), a protein found on the surface of the
influenza virus that enables the virus to enter a
human cell and initiate infection.
The
vaccines targeted an
influenza A H1N1 seasonal flu strain as well as A (H7N9), a virus considered to have the potential to trigger a
human pandemic.
When they delivered this virus into the noses of mice and ferrets, the animals» epithelial cells produced the desired antibodies; they then «challenged» the animals with a range of dangerous
influenza viruses that no single
vaccine can outwit, including H5N1, which kills both birds and
humans, and the H1N1 that caused the infamous 1918 pandemic.
If the administration of the quadrivalent
influenza vaccine was expanded sufficiently — it may be possible to eradicate the slower Yamagata lineage from
humans.
The loss was bad for the
vaccine: In a series of experiments Hensley and his colleagues showed antibodies from
humans and ferrets (a good animal model for
influenza A studies) that had been exposed to the egg - grown
vaccine did not effectively kill the circulating sugar - adorned viruses.
Indeed, weakening
influenza strains by passaging them in animals is an old technique for making
human vaccines, including those for polio and yellow fever, according to virologist Vincent Racaniello of Columbia University.
CDC researchers took ferrets never infected with an
influenza virus and injected them with this year's
vaccine, which has an H1N1 component of
human, not swine, origin.
For
influenza we offer the ferret model, the «gold standard» for infections with
human influenza viruses, which will be used to assess the efficacy of
vaccine candidates.
A trivalent inactivated seasonal
influenza vaccine (TIV) used in
humans will be compared directly in mice, ferrets and pigs.
In April 2017, Moderna published
human data for its mRNA
vaccine technology in Molecular Therapy, which showed that its first prophylactic
vaccine candidate, mRNA - 1440 — an mRNA prophylactic
vaccine against avian H10N8
influenza — induced high levels of immunogenicity and was safe and well tolerated.
Specifically, we will test samples from aged and, as a control, younger
human subject before and after vaccination with the trivalent inactivated
influenza vaccine (TIV) in an exploratory / confirmatory study design to assess age - related responsiveness to the
vaccine.
The study relates to a particular type of
vaccine (killed) against a particular virus,
influenza, though the findings might hold true for other killed
vaccines and for those
vaccines consisting only of proteins produced by GM in bacteria, yeast or insect cells, against diseases such as hepatitis B (HBV) and
human papilloma virus (HPV, the causative agent of cervical cancer).
Duke researchers have devised a way to keep the
human influenza virus from mutating during production, generating a perfect match to the target
vaccine in a shorter time frame.
The idea behind a â $ œHuman
Vaccine Projectâ $ is to combine efforts at developing
vaccines for major (but very different) diseases such as
influenza, dengue, HIV, hepatitis C, tuberculosis and malaria, with the rationale that what scientists working on those diseases have in common is the Ray Ban outlet challenge of working with the
human immune system.
Waisman Biomanufacturing, notes Ross, has a long history of producing experimental
vaccines for clinical trials, including for HIV,
influenza, hepatitis, herpes and
human papillomavirus, among others.
Sinovac Biotech Ltd. is biopharmaceutical company that focuses on research, development, manufacturing and commercialization of
vaccines that protect against
human infectious diseases including hepatitis A and B, seasonal
influenza, H5N1 pandemic
influenza and mumps, as well as animal rabies
vaccine.
The Centers for Disease Control (CDC) monitors the
human influenza virus and updates how
vaccines are produced to provide maximum protection.
Similar to how the
vaccine works in
humans, the
vaccine may not prevent your pet from getting the flu, but may greatly diminish the clinical signs of
influenza and the associated complications.
He has also generated attenuated viruses as
vaccine candidates, for the treatment of
influenza and arenavirus infections in
humans and other mammalians.
The bad news is how much that $ 100
vaccine costs your dog... especially considering that, just like the
human flu, canine
influenza is a self limiting, normal illness that, in the vast majority of dogs, amounts to a couple of days of feeling sick.