Sentences with phrase «human islet cells»

Researchers addressed B - cell lines and human Islet cells with preparations of turmeric and observed positive benefits.

We observed that this pathogenic process was active in human islet cells obtained from donors with type 2 diabetes... [7]

Initially, Novocell experimented with implanting micro-encapsulated human islet cells.

TIMP - 1, previously described as being able to protect against cytokine and STZ ‐ induced β cell death [5, 6], was one of the most enriched factors in co-culture experiments using mouse and human islet cells, and the authors found that TIMP - 1 was induced by pro-inflammatory factors which are commonly associated with T1DM.

San Diego, CA (December 9, 2008)-- Novocell, Inc., a stem cell engineering company, today announced a collaboration with renowned stem cell researcher Dr. Shinya Yamanaka of Kyoto University, Japan, to allow Novocell to explore the creation of human islet cells from induced pluripotent stem (iPS) cells.

Novocell also demonstrated earlier this year, that hES - derived pancreatic progenitorsdevelop into human islet cells capable of producing insulin in response to glucose and ameliorating diabetes in animal models.

Image of non-diabetic healthy human islet cells that reside in pancreas.

Doug Melton has put in a life - time of hard work in finding a way of generating human islet cells in vitro.

«This is a unique and valuable resource for researchers wishing to begin to understand how gene expression is dynamically regulated in human islet cells,» said Kim.

«Studying human islet cells has been a major challenge in the field of diabetes research for decades because the pancreas essentially digests itself shortly after a person's death,» said professor of developmental biology Seung Kim, MD, PhD.

Not exact matches

Using cells from cadavers, doctors have been experimentally transplanting pancreatic islets into humans for decades, but as many as 60 percent of the transplanted islets die immediately because they are cut off from their blood supply and are killed by an immune response due to direct injection into the bloodstream, and those that survive the transplant usually die within several months.

In addition to looking at mouse models of diabetes, the researchers also showed that exposure of human pancreatic islet cells — both from healthy donors and from patients with Type 1 diabetes — to fasting - mimicking diet in a dish stimulated insulin production.

Whatever the source of pluripotent cells, Thomson says, researchers face the same scientific challenges — namely, understanding how to convert them into key tissues such as the beta islet cells that are impaired in diabetics, and then how to introduce them safely and effectively into humans.

This is an image of human stem cell - derived beta cells that have formed islet like clusters in a mouse.

Investigators found that autophagy plays a role in clearing IAPP from pancreatic beta cells using three experimental models: pancreatic beta cells, isolated pancreatic islets from mice that express the human form of IAPP, and human islets.

To corroborate the findings, the researchers also developed a novel mouse model that was deficient for autophagy specifically in beta cells with expression of the human form of islet amyloid polypeptide.

In these two microscopy images, human islets (the source of insulin cells) were poisoned with a drug to remove the insulin cells, and then treated with either an empty virus (left panel) or the therapeutic virus (right panel), and then grown in a diabetic mouse.

Replication increases β - cell vulnerability to human islet amyloid polypeptide - induced apoptosis

Autopsy studies in humans suggest that islet amyloid is associated with the loss of β cells mass (Clark et al., 1988).

Diabetes due to a progressive defect in β - cell mass in rats transgenic for human islet amyloid polypeptide (HIP rat): A new model for type 2 diabetes

«ViaCyte was the first to differentiate human stem cells into glucose - responsive, insulin - producing cells, and now we are running the first and only clinical trials of stem cell - derived islet replacement therapies for type 1 diabetes,» said Paul Laikind, PhD, President and CEO of ViaCyte.

Maturation of human embryonic stem cell - derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice.

Paracrine signalling loops in adult human and mouse pancreatic islets: netrins modulate beta cell apoptosis signalling via dependence receptors.

Coating Human Pancreatic Islets With CD4 + CD25highCD127 - Regulatory T Cells as a Novel Approach for the Local Immunoprotection.

Following implantation, the cells should develop into human islet tissue, capable of regulating blood glucose.

Assessment of hASC - CM composition found high expression of various human growth factors (IL ‐ 6, 8, 12, eotaxin, IP10, MCP ‐ 1, VEGF, and TIMP ‐ 1) in the supernatant following the co-culture of hASCs with islet cells, while IP10, eotaxin, VEGF, and TIMP ‐ 1 became increased with time during islet co ‐ culture, suggesting the presence of paracrine cross ‐ talk between islets and hASCs.

The Emory Transplant Center has conducted clinical trials since 2003 transplanting human pancreatic islet cells into patients with Type I diabetes.

But the application describes ViaCyte's technology, which grows pancreatic «islet» cells from human embryonic stem cells.

The pluripotent stem cell process could allow researchers to make genetic changes to dampen or potentially eliminate the rejection of the pig islets by the human immune system.

Chong Wee Liew, Ph.D., lead author and a postdoctoral researcher in the Kulkarni lab, first examined the expression of the tribbles protein in pancreatic islets (which house beta cells and other hormone - producing cells) in both humans and mice.

After implantation, these cells are expected to become mature human islet tissue including well - regulated beta cells producing insulin on demand.

The markers highlighted the striking diversity of beta cell aging, and functional decline, both within and between islets in both mouse and human pancreases.

Methods: Here we model human β - cell dedifferentiation using growth factor stimulation in the human β - cell line, EndoC - βH1, and human pancreatic islets.

Poster: In vitro generation of insulin producing cells with insulin secretion kinetics and mitochondrial respiration similar to adult human islets [Poster T2190] Speaker: Dr. Alireza Rezania, Senior Director, Discovery Date / Time: June 23, 7:00 p.m. to 8:00 p.m., PDT

Human islet amyloid polypeptide expression in COS - 1 cells.