Sentences with phrase «human liver tumors»

«We were excited to see that in human liver tumors mTORC1 signaling correlates with FGF21 expression,» comments cell biologist Dr. Marion Cornu and first author of the study.

Activated mTORC1 signaling (top) correlates with increased FGF21 expression (below) in human liver tumor.

Not exact matches

Researchers have injected mice with human breast, ovary, colon, bladder, brain, liver and prostate tumors, and their new drug has killed the tumors every time.

So he implanted various human tumors — including ovarian, breast, colon, liver, and brain — into mice and then injected the animals with antibodies that disable CD47.

A virus that has shown promise as a vector for human gene therapy causes liver tumors in neonatal mice.

Similar to humans, the mice developed tumors at secondary sites including the liver, lung, peritoneum, and diaphragm.

Rather than artificially triggering cancer by engineering genetic mutations, this model more closely mimics human liver cancer in that tumors develop as a natural consequence of non-alcoholic steatohepatitis (NASH), a chronic metabolic disorder that causes liver damage, fibrosis and numerous cell mutations.

In humans, colon cancer often spreads to the liver and forms small tumors that are difficult to detect, similar to ovarian tumors.

Researchers from Charité — Universitätsmedizin Berlin, the Medical University of Graz and the German Institute of Human Nutrition in Potsdam - Rehbruecke have found that p53, one of the most important tumor suppressors, accumulates in liver after food withdrawal.

Once formed, many of these experimental tumors spread to the liver, just like human colon cancers often do.

«New MRI approach detects early liver tumors in mouse model of human disease.»

↵ 3 The abbreviations used are: HUVEC, human umbilical vein endothelial cell; DiI - Ac - LDL, 1,1 ′ - dioctadecyl - 3,3,3 ′, 3 ′ - tetramethyl - indocarbocyanine acetylated low - density lipoprotein; FACS, fluorescence - activated cell sorting; FGFR, fibroblast growth factor receptor; Flk, fetal liver kinase; ICAM, intercellular adhesion molecule; mAb, monoclonal antibody; PE, phycoerythrin; TNF, tumor necrosis factor; VCAM, vascular cell adhesion molecule.

Additionally, overexpression of POSTN in human mammary epithelial and breast cancer cells resulted in enhanced tumor growth and metastasis (Wang et al., 2013), which is similar to a colon cancer cell model where overexpression of POSTN resulted in an increase in the number and size of liver metastases (Bao et al., 2004).

In fact, large human liver cancer tumors on comparatively small mice started regressing about 20 days after treatment, and were eradicated by day 41 with the help of one of the targeted receptors.

Next steps include He's collaboration with Piedmont Atlanta Hospital to retrieve T cells, liver cancer cells and healthy tissue normally removed from patients during surgery, put the mouse receptor genes on these T cells and monitor in a dish both how those cells now fight the tumor and react to healthy human tissue.

Further research uncovered a broad spectrum of cell surface stem cell markers (e.g., CD133, CD44, and CD24) that allow the identification of CSCs in human solid tumors, including brain, breast, prostate, pancreas, liver, ovary, skin, colon cancers, and melanoma (3 - 6)(Figure 1 based on 7).

For this study, the researchers closely examined an ordinary tumor removed from a human liver.

Studying cells from the stomach and pancreas in humans and mice, as well as mouse kidney and liver cells, and cells from more than 800 tumor and precancerous lesions in people, the researchers found when tissue is injured by infections or trauma, mature cells can revert back to a stem - cell state in which they divide repeatedly.

Still, by the 1990s DuPont knew that the chemical caused cancerous tumors in the testes, pancreases, and livers of lab animals, and there was even evidence of human DNA damage and links to prostate cancer in workers exposed to PFOA.

This finding was reinforced by an animal study, in which tocotrienol inhibited tumor growth in mice that had been injected with human liver cancer cells.

This evidence stems from the fact that eating foods that resemble the protein structure of humans causes the liver to release excess amounts of the growth hormone, IGF - 1, which accelerates aging and promotes tumor growth.

Phytates have been shown to inhibit the growth of human leukemia cells, colon cancer cells, both estrogen receptor - positive and negative breast cancer cells, voicebox cancer, cervical cancer, prostate cancer, liver tumors, pancreatic, melanoma, and muscle cancers.

«A human heart that was slowly transforming into bone; cancerous livers, a cancerous testicle so enlarged by its disease that a special case had to be built to contain it; tumors sliced from noses, throats.»