In the second study in Science, researchers from Harvard University in Boston, Massachusetts, created a chip 1 to 2 centimeters long in which a 1 millimeter - wide channel, coated with
human lung cells on the inside and overlaid with human blood capillaries on the outside, mimicked the air sacs, or alveoli, of the lungs.
Not exact matches
Panoskaltsis - Mortari's team has been working
on rebuilding
lungs and other parts of the respiratory system using
human stem
cells.
To create the effect of tobacco smoke
on cells, Vaz, Baylin and their colleagues began their studies with
human bronchial
cells, which line the airways of the
lungs, and grew them in a laboratory.
Scientists have long experimented with organs -
on - chips: tiny representations of
human organs, such as
lungs, hearts and intestines, made from
cells embedded
on plastic about the size of a computer memory stick.
Potti and his colleagues began by testing chemotherapy drugs
on cultured
cell lines from
human tumors, such as from the
lung, breast, or ovary.
In experiments conducted
on human lung endothelial
cells and in mice, the researchers showed that NS1 caused permeability of the endothelium, which lines the walls of blood and lymph vessels.
Last June Ingber's team reported that it had placed
human lung lining
cells and
human capillary
cells on either side of a porous, flexible polymer membrane.
First, the destabilizing effects of VX - 770
on the corrected CFTR protein might be less robust in the
human body than were the effects seen in lab tests using
human lung cells.
One postdoc presents data
on her efforts to develop an organoid model for small -
cell lung cancer; another reports progress
on culturing hormone - secreting organoids from
human gut tissue.
«The introduction of mitochondria into damaged
cells has beneficial effects
on the health of
cells and, in the long term, we believe that mesenchymal stem
cells could even be engineered to create more effective therapies for
lung disease in
humans.»
Our investigations
on human cell lines in the laboratory have shown that synthetic cannabinoids, in the high concentrations found in
cells in the oral cavity or in the
lungs, for example, are likely to trigger damage to the DNA that may have significant consequences for the consumers of such substances.
Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 • Have histologically or cytologically confirmed advanced or metastatic non-small
cell lung cancer (NSCLC)(Stage IIIb or greater) • Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 • Known PD - L1 tumor status as determined by an immunohistochemistry (IHC) assay performed by the central laboratory
on tissue obtained at Screening • A woman of childbearing potential must have a negative highly sensitive serum (beta -
human chorionic gonadotropin [beta - hCG]-RRB- at Screening within 14 days prior to study drug administration Inclusion Criteria for Crossover: • Participants must have been randomized to Arm A of the study and had radiographic disease progression according to RECIST 1.1 • Participants must have a mandatory biopsy at the time of disease progression according to RECIST 1.1 prior to crossing over.
Organ -
on - a-chip technology may in part overcome this limitation, as exemplified by the «breathing»
lung -
on - a-chip that recapitulates the alveolar - capillary interface by co-culturing
human alveolar epithelial
cells and capillary endothelial
cells on opposite sides of a flexible, porous, ECM - coated membrane.
To assess the expression of Tie2 and other Ang / Tie signalling molecules
on human pericytes, a microarray - based expression profiling of
human brain pericytes (BP), placenta pericytes, pancreas pericytes (PA),
lung pericytes (LP), muscle pericytes (MP) and
human umbilical vein endothelial
cells (HUVEC) was performed.
Recent work from Fousteri Lab revealed a novel metabolic function of active transcription that is rapidly switched
on globally in
human cells to promote genetic accuracy, and reduce the mutation burden in genotoxins - exposed tissues, such as skin and
lung, thus actively participating in lowering oncogenesis.
Building
on that project, the researchers have now designed a machine that smokes cigarettes in a very
human - like manner, and hooked it up to organs -
on - chips lined by
human lung small airway
cells so the smoke interacts with these
cells in a realistic way.
In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent
cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these
cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor
cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic
lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with
human clinical trials expected to begin in 2019.
A study from Dr. Dusty Miller's laboratory indicates that Jaagsiekte sheep retrovirus (JSRV) infects both sheep and
human cells cultured outside the body and does so by attaching to a receptor
on the surface of
lung cells.
The Swedish part of the effort, called the
Human Developmental
Cell Atlas (HDCA) program, includes researchers from Karolinska Institutet, Stockholm University and KTH, focusing
on brain,
lung, heart and fetal development during the first 12 -LSB-...]
The meeting will also feature other aspects of the
Human Cell Atlas initiative, including updates
on progress so far towards atlases of tumour,
lung, gut, kidney and immune system
cells.
«Study of the pro-apoptotic effect of molecules interfering with epigenetic mechanisms
on human lung cancer
cells».
The result was a highly selective drug they named SBI - 0206965, which successfully killed a number of cancer
cell types, including
human and mouse
lung cancer
cells and
human brain cancer
cells, some of which were previously shown to be particularly reliant
on cellular recycling.
Title of thesis: «Study of the pro-apoptotic effect of histones deacetylases inhibitors, used alone and concurrently with chemotherapeutic agents,
on human lung cancer
cells».
The effect of diet
on the gluconeogenic capacity of rat - kidney - cortex slices [5] Liver and kidney metabolism during prolonged starvation [6] Unrecognized Pandemic «Subclinical» Diabetes of the Affluent Nations: Causes, Cost and Prevention [7] Carbohydrates and Immune Function [8] Overexpression of glut1 and glut3 in stage I nonsmall
cell lung carcinoma is Associated with poor survival [9] The in?uence of diet
on the mucin carbohydrates in the chick intestinal tract [10] Rat intestinal mucosal responses to a microbial flora and different diets [12] Chronic Ethanol Induced Impairment of Hepatic Glycosylation Machinery in Rat Is Independent of Dietary Carbohydrate [13] Glycosylation in Cellular Mechanisms of Health and Disease [14] Metabolic Aberrations Associated with Arginine Deficiency [15] Glycerol gluconeogenesis in fasting
humans
STUDY TWO — next we have this study in which scientists analysed the effect of fluoride
on human lung cells.