Sentences with phrase «human lung tumors»

The cells exhibited many functions associated with tumor progression; their presence within mouse tumors substantially accelerated cancer growth, and in human lung tumors, a SiglecFhigh neutrophil signature was associated with poor patient survival.

Not exact matches

Potti and his colleagues began by testing chemotherapy drugs on cultured cell lines from human tumors, such as from the lung, breast, or ovary.

Compared to a control (left), epalrestat treatment (right) reduces the number of metastatic tumors (arrowheads) in the lungs of mice injected with human basal - like breast cancer cells.

They found out that TiY is capable of distinguishing TICs from non-TICs in various human lung cancer cell lines and patient - derived lung tumors.

One of those genes, K - Ras, which was discovered nearly 30 years ago, is mutated in 30 percent of human tumors, including 90 percent of pancreatic cancers, 40 percent of colon cancers, and 20 percent of non-small cell lung cancers.

Similar to humans, the mice developed tumors at secondary sites including the liver, lung, peritoneum, and diaphragm.

To test this idea, the researchers utilized two mouse models of human breast cancer metastasis and found dormant disseminated tumor cells residing upon the membrane microvasculature of lung, bone marrow and brain tissue.

By using molecular genetic tools to reduce the amount of PC in human lung cancer cells, the team observed decreased cell growth, a compromised ability to form colonies in soft agar (a gelatinous material specifically used to grow bacteria and other cells), and a reduced rate of tumor growth in mice.

They also tested other cancer lines — human cervical, lung and prostate cancers — and found that they responded to the patterned tumor environments in the same way.

«For example, mouse mammary tumors shared a signaling pathway that is found in human lung cancer and controls how cells reproduce and move from one location to another.»

The researchers grafted breast or lung tumors in mice, allowed the tumors to grow to small size and removed these tumors surgically — essentially mimicking the situation in a human tumor patient in which the tumor is surgically removed as soon as possible after diagnosis.

Being both tumor - specific and widely expressed in human tumors, MAGE - A3 is an ideal cancer vaccine target and will be the focus of many clinical trials, including the largest clinical trial ever conducted in lung cancer, MAGRIT, launched by GlaxoSmithKline in 2007.

IHC - P mouse tumor tissue (from lung) with human cell line injected, some muscle tissue attached as well sees high background for human cellswith priamry Ab as well as isotype ctrl, but also for muscle (does not contain any EGF) Ab: 1 ug /...

Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 • Have histologically or cytologically confirmed advanced or metastatic non-small cell lung cancer (NSCLC)(Stage IIIb or greater) • Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 • Known PD - L1 tumor status as determined by an immunohistochemistry (IHC) assay performed by the central laboratory on tissue obtained at Screening • A woman of childbearing potential must have a negative highly sensitive serum (beta - human chorionic gonadotropin [beta - hCG]-RRB- at Screening within 14 days prior to study drug administration Inclusion Criteria for Crossover: • Participants must have been randomized to Arm A of the study and had radiographic disease progression according to RECIST 1.1 • Participants must have a mandatory biopsy at the time of disease progression according to RECIST 1.1 prior to crossing over.

Mutation rates ten-fold higher than typical lung cancers in humans, though within three-fold of «hypermutator» tumors with mutations in DNA repair genes.

In this fashion, they derive a signal from the tumor cells proportional to tumor mass which arises spontaneously in vivo in the accurate setting of the lung and from the accurate genetic lesions found in human non-small cell lung cancer (NSCLC).

Tags: Acute Myeloid Leukemia, Anne McTiernan, cancer prevention, Computational Biology, exercise, genetic mutation, Harlan Robins, Human Biology, Lung Cancer, national science foundation, obesity, Pancreatic Cancer, physical activity, Public Health Sciences, stand up to cancer, Tumor specific translational research

Flavopiridol inhibits several cellular kinases and has demonstrated cytostatic and cytotoxic activity in vitro and in vivo in numerous human tumor cell lines and xenograft models (including human breast, prostate, and lung carcinoma) at clinically achievable concentrations.

In this study, human lung cancer cells with additional copies of the opioid receptor grew more than twice as fast as tumor cells that lacked extra receptors when transplanted into mice.

Revealed that the loss of the human leukocyte antigen (HLA) locus in lung cancers is a way these tumors evade the immune system and allow mutation expansion and branched evolution within tumor cells

The most frequent tumors in human — cancer of the colon, breast, lung, and prostate — all involve mutations in tumor suppressor genes.

Infections in humans do not completely develop, but may cause a lesion in the lungs «coin sign» that may be mistaken for a tumor.