Human macrophages are a type of immune cell that helps our bodies to fight off infections and diseases. They "eat" harmful bacteria, fungi, and viruses, protecting us from getting sick.
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Although this study was done in mice, the same mechanisms were found
in human macrophages infected with TB.
Legionella pneumophila, the bacterial cause of Legionnaires» disease, lives symbiotically inside wild aquatic amoebas and similarly mistakenly
infects human macrophages when victims inhale it.
They will
study human macrophages and dendritic cells isolated from IBD patients with defective GM - CSF function, «The approach represents a step forward in personalizing how we treat patients with IBD,» said Dr. Colombel.
When they
put human macrophages in the lower compartment filled with cell culture medium, the cells rose toward the membrane.
Multispecific monoclonal antibodies bind to
primary human macrophages and induce the production of protective chemokines, MIP - 1 and MIP - 2
The researchers next showed that the Smurf1 gene controls M. tuberculosis growth
in human macrophages and that the Smurf1 protein was found in association with bacteria in the lungs of patients with tuberculosis infections.
To make this discovery, Serhan and colleagues deconstructed the biosynthetic pathway for maresin biosynthesis and found that
human macrophages are responsible for converting DHA to the novel epoxide intermediate «13S, 14S - epoxy - maresin.»
To make their discovery, Dr. Prantner and his colleagues used isolated mouse and
human macrophages in vitro, and a mouse influenza infection model.