Sentences with phrase «human melanoma associates»

Up - regulated expression of zonula occludens protein - 1 in human melanoma associates with N - cadherin and contributes to invasion and adhesion.

Not exact matches

In a series of studies led by Dr. Arun Sharma, associate professor of pharmacology and Dr. Shantu Amin, professor of pharmacology, both of Penn State College of Medicine, researchers designed and synthesized a compound called napthalamide - isoselenocyanate — NISC - 6 — to inhibit both the Akt1 pathway and human topoisomerase IIα — topo IIα — activity, which contribute to melanoma tumor growth.

The analysis also found that a significant fraction of tumors contained rearrangements and mutations of a gene called PREX2, and experiments confirmed that cancer - associated mutations of PREX2 promoted the growth of human melanoma cells in mice.

Over 50 human genomic loci are associated with either pigmentation phenotypes or melanoma susceptibility.

Both mutations affect the function of CDKN2A, a tumor suppressor gene associated with melanoma in humans.

Melanoma is a classical skin cancer of humans, and in humans it is associated with sun exposure.