«New therapies for ALS are urgently needed — and our creation of
human models using iPS cell technology will hopefully deepen our understanding of how the disease develops — and lead to relevant therapies for patients,» said Senior Investigator Steve Finkbeiner, MD, PhD, who leads ALS research at Gladstone.
Not exact matches
By
using our own brain as a
model, this technology is able to apply
human intuition at machine speed.
As
human beings, we frame new phenomenon
using our existing mental
models, which means we need to think differently in order to succeed in this new era of digital change.
Currently SQZ is developing its technology further
using mouse
models and
human blood experiments to understand its mechanisms of action more fully.
Using an algorithm complete with 3 - D
human body
modeling, the company then makes a recommendation as to which of its mattresses is the best fit.
Boston Dynamics has produced a number of robots that mimic
human and animal movement, including Atlas, a humanoid
model that co-ordinates motion and balance
using its arms and legs and can pick itself up off the ground when knocked over.
In the early 1990s the
models that most economists
used to analyze and explain Chinese economic growth were good enough, like the Newtonian bridge in the slow moving world in which
humans operate.
«I got really interested in trying to understand how we could
model human behavior through social media because there's residue of who we are in everything we do and here we had lots of little behaviors that we could
use to try to understand a little bit more about who you are.»
Eco-modernism is about finding new technologies and financing
models that allow
humans to prosper while
using less land, water, fuel, and energy and interfering less with the natural world.
Using human experience as a
model to depict the nature of reality, Whitehead argues that every actuality (i.e., every actual event) has both a present subjective immediacy and a past objectivity.
If there is a basic thesis, it is that Whitehead has
used the concept of the electromagnetic field in physics as a
model for
human experience (PW 125/134, 183/201; RL 285).
Kaufman is unafraid to be — to
use two of his favorite adjectives — both
human and humane, honest about both his caution and his passions, and in that he provides even those of us who disagree with him with an admirable
model of how to be a theologian.
Using the Deuteronomic Creed as
model, Dalit theology can construct the historical Dalit consciousness which has to do with their roots, identities and struggle for
human dignity and «for the right to live as free people created in the image of God.»
The
models often
used to describe this have been unsatisfactory, to be sure: talk of «substance» has led to much confusion and misunderstanding, as has talk of the union of wills or the association of divine /
human consciousnesses.
Although we have limited ourselves in this chapter to the discussion of dialogue within the Church, we must not forget that Vatican II also
used the term «dialogue» to refer to communication with separated Christians, 10 with non-Christians and atheists, 11 with the entire
human family, and with the world.12 This aspect deserves our attention even more than the
use of the dialogue
model for exchanges within the Church.
A
model which portrays divine initiative would limit the
use of a
model which portrays
human response, and vice versa.
The «revelation
model» helps to restore the balance,
using the dynamic categories of divine and
human activity in place of the more static categories of substances and natures.
Perhaps we shall soon be able to
use as our guide and
model the fully growing and self - fulfilling
human being, the one in whom all... potentialities are coming to full development.»
Using a «gnotobiotic mouse
model» — where mice were «colonized with a synthetic
human gut microbiota composed of fully sequenced commensal bacteria» — Desai et al reported on the effects of different diets with different fibre content.
Before we established in - house
human taste cell (HTC) technologies, it was not possible to
use human tongue - derived cells as a
model, due to the lack of homogenous, proliferating cell lines with defined properties, which is a prerequisite to establish comprehensive research and screening programs.
The American Association of Pediatricians statement on breastfeeding and the
use of
human milk (2005) states, «Exclusive breastfeeding is the reference or normative
model against which all alternative feeding methods must be measured with regard to growth, health, development and all other short and long - term outcomes.»
Hypoglycemia, Going Home / Discharge, Supplementation, Mastitis, Peripartum BF Management, Cosleeping and Breastfeeding,
Model Hospital Policy,
Human Milk Storage, Galactogogues, Breastfeeding the Late Pre-term Infant, Analgesia and Anesthesia for the Breastfeeding Mother, Breastfeeding the Hypotonic Infant, Guidelines for Breastfeeding Infants with Cleft Lip, Cleft Palate, or Cleft Lip and Palate,
Use of Antidepressants in Nursing Mothers, Breastfeeding Promotion in the Prenatal Setting, Engorgement, Breastfeeding and the Drug - Dependant Woman, Jaundice, Non-Pharmacologic Management of Procedure - Related Pain in the Breastfeeding Infant, Allergic Proctocolitis in the Exclusively Breastfed Infant, Preprocedural Fasting for the Breastfed Infant
While our work has
used mouse
models because we can study the process in detail this way, we do know that milk cells cross into
human babies as well.»
As well as allowing the
use of stem cells grown from established cell lines, the technology could enable the creation of improved
human tissue
models for drug testing and potentially even purpose - built replacement organs.
Studies show that these
models can accurately predict the ways that new drugs will react in the
human body and replace the
use of animals in exploratory research and many standard drug tests.
In collaboration with Synchrotron Oxford, the University of East Anglia and the University of California, the researchers,
using a commonly - found member of
human gut microbiota called Ruminococcus gnavus as a
model organism identified carbohydrate binding modules with the ability to bind to mucus.
While many
humans enjoy a daily caffeine fix, scientists have found that caffeine repels Drosophila melanogaster — a species of fruit fly often
used as a
model for studying
human conditions and genetics.
For the first time, researchers
used human cells to build a
model of the surface of the eye that's equipped with a fake eyelid that mimics blinking.
Using a mouse
model that expresses an altered form of the normal
human prion protein, researchers at University of California, San Diego School of Medicine have determined why the
human proteins aren't corrupted when exposed to the elk prions.
Using gene editing to create rodents that are ideal research
models could narrow the genetic divide between
humans and their animal stand - ins.
These findings allowed researchers to create a chimera virus: a mouse virus with a
human viral gene that can be
used to test molecules that inhibit
human LANA protein in an animal
model of disease, treating not only
human herpes virus infection but also its associated cancers.
The behavioral tests
used here
modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in
humans, he says.
The scientists performed pre-clinical trials
using experimental autoimmune encephalomyelitis, a pre-clinical
model for
human multiple sclerosis.
The new drug - like compounds discovered by Vogel and her co-authors offer hope that
using a computer - generated P - gp
model, explained here http://bit.ly/1LVmR7a, developed to accurately mimic the physical, chemical and biological functions of the protein in the
human body, will speed up the drug discovery process and work in real life as well.
The paper suggests that regulation is the best way to achieve this and highlights the frameworks
used to regulate commercial
use of organic
human remains as a good
model to build on.
«Essentially, we are
using the
human placenta as a
model to identify genes that play a key role in invasion in both the placenta and cancer,» wrote Chi Sutherland, a Ph.D. candidate leading the project, in an email.
The cognitive
model has been validated
using a database of about 1500 input sentences, based on literature on early language development, and has responded by producing a total of about 500 sentences in output, containing nouns, verbs, adjectives, pronouns, and other word classes, demonstrating the ability to express a wide range of capabilities in
human language processing.
To demonstrate the effects of bullying, the researchers
used an animal
model simulating the physical and emotional stressors involved in
human bullying — chronic social defeat stress.
Pig brains are remarkably similar to
human brains, so they are often
used as
model systems by neuroscientists.
The study results were found
using mouse embryonic stem cells, which are good cell
models for the study of processes seen in
human stem cells.
«A network of artificial neurons learns to
use human language: A computer simulation of a cognitive
model entirely made up of artificial neurons learns to communicate through dialogue starting from a state of tabula rasa.»
Using a mathematical
model known as the Ising
model, invented to describe phase transitions in statistical physics, such as how a substance changes from liquid to gas, the Johns Hopkins researchers calculated the probability distribution of methylation along the genome in several different
human cell types, including normal and cancerous colon, lung and liver cells, as well as brain, skin, blood and embryonic stem cells.
Dr Luis Pedro Coelho, commented: «These findings suggest that dogs could be a better
model for nutrition studies than pigs or mice and we could potentially
use data from dogs to study the impact of diet on gut microbiota in
humans, and
humans could be a good
model to study the nutrition of dogs.
Zebrafish are commonly
used to
model human diseases, in part because their larvae are transparent, making it easy to see the effects of genetic mutations or drugs.
«Our study validates
using fruit flies as a
model to discover new genes that may also control aggression in
humans.»
The ANNABELL
model is a cognitive architecture entirely made up of interconnected artificial neurons, able to learn to communicate
using human language starting from a state of «tabula rasa» only through communication with a
human interlocutor.
The researchers
used information on a reef's habitat, depth, nearby
human population and amount of fishing to
model how many fish could live at each site.
One of Dozier's evolutionary computation projects
uses the
human immune system to
model a network security system.
A group of researchers from the University of Sassari (Italy) and the University of Plymouth (UK) has developed a cognitive
model, made up of two million interconnected artificial neurons, able to learn to communicate
using human language starting from a state of «tabula rasa,» only through communication with a
human interlocutor.
Using young rhesus monkeys in our
model of anxious temperament is critical as brain structure and function in non-human primates closely resembles that of
humans.»