Key Highlight: • Facilitated the introduction of HUMIRA (adalimumab) for the healthcare professionals as the latest and the only
fully human monoclonal antibody against TNF for the treatment of moderate to severe psoriasis in patient failed at least on two DMARD's.
Watkins and Dennis Burton, Ph.D., chairman and professor of the Department of Immunology & Microbiology at the Scripps Research Institute, led the collaborative international study, «
Neutralizing Human Monoclonal Antibodies Prevents Zika Virus Infection in Macaques,» published recently in Science Translational Medicine.
Researchers at Vanderbilt University Medical Center and the University of Texas Medical Branch in Galveston (UTMB) reported today in the journal Cell that they have isolated
human monoclonal antibodies from Ebola survivors which can neutralize multiple species of the virus.
Researchers at Vanderbilt University Medical Center and the University of Texas Medical Branch in Galveston (UTMB) reported this week in the journal Cell that they have
isolated human monoclonal antibodies from Ebola survivors that can neutralize multiple species of the virus.
Scientists looking at the antiviral mechanisms of two previously
identified human monoclonal antibodies have found they potently inhibit chikungunya virus (CHIKV) at multiple stages of infection.
Over the past couple of years, the Crowe lab has
produced human monoclonal antibodies that can neutralize, or kill, a wide range of potentially lethal viruses, including chikungunya, dengue, Ebola, and its close cousin, Marburg.
«Development Trends
for Human Monoclonal Antibody Therapeutics,» by Aaron L. Nelson, Eugen Dhimolea and Janice M. Reichert, Nature Reviews Drug Discovery, October 2010.
«The remarkable advance in technologies to isolate and manufacture
human monoclonal antibodies in concentrations high enough to potentially prevent HIV is a major advance and provides the underlying principle for our enthusiasm for these trials.»
Denosumab, a fully
human monoclonal antibody drug, binds specifically to RANK - ligand (RANKL) and inhibits osteoclast - induced bone resorption by preventing the binding of RANKL to RANK.
Dupilumab, a fully
human monoclonal antibody discovered by Regeneron Pharmaceuticals and being developed by Regeneron and Sanofi, thwarts activation of the Th2 immune response implicated in asthma by blocking two cytokines, interleukin - 4 and interleukin - 13.
«This panel of neutralizing antibodies offers the possibility of
developing human monoclonal antibody - based immunotherapy, especially for health care workers,» noted the authors.
Guselkumab, a fully
human monoclonal antibody targeting IL - 23, in this Phase 2 study for the treatment of PsA, was well tolerated with no unexpected safety findings in this patient population.2 Guselkumab is now being pursued in a Phase 3 development programme for psoriatic arthritis.
Tsibane T, Ekiert DC, Krause JC, Martinez O, Crowe JE, Wilson IA, Basler CF.
Influenza human monoclonal antibody 1F1 interacts with three major antigenic sites and residues mediating human receptor specificity in H1N1 viruses.
Scientists looking at the antiviral mechanisms of two previously
identified human monoclonal antibodies have found they potentially inhibit chikungunya virus (CHIKV) at multiple stages of infection.
We demonstrated that DENV serotype 2 (DENV2)--
specific human monoclonal antibody (HMAb) 2D22 is therapeutic in a mouse model of antibody - enhanced severe dengue disease.
Weiner, Elliott and colleagues studied the DNA sequences for two
human monoclonal antibodies — one able to broadly target influenza A viruses and one able to broadly target influenza B viruses — with collaborators at Inovio and MedImmune.
Here we report the generation of aducanumab,
a human monoclonal antibody that selectively targets aggregated Aβ.
Researchers have now been able to show that Aducanumab,
a human monoclonal antibody, selectively binds brain amyloid plaques, thus enabling microglial cells to remove the plaques.
A phase I trial of ramucirumab,
a human monoclonal antibody against the vascular endothelial growth factor - 2 (VEGFR - 2) receptor, in children with refractory solid tumors, including CNS tumors (NCT02564198).
A phase I trial of ramucirumab,
a human monoclonal antibody against the vascular endothelial growth factor - 2 (VEGFR - 2) receptor, in children with refractory solid tumors, including CNS tumors -LRB-
Some of the important and pioneering work for which Cambridge is best known and which has led to major improvements in people's lives was only possible using animals, from the development of IVF techniques through to
human monoclonal antibodies.
There will be an ongoing need for a human post exposure therapeutic and so we're continuing our work with
the human monoclonal antibody as a treatment that can be given to people who are exposed to Hendra virus.
Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses.
Erenumab uses fully
human monoclonal antibodies to block a molecule that transmits migraine pain signals during a migraine.