Sentences with phrase «human monoclonal antibody targeting»

Guselkumab, a fully human monoclonal antibody targeting IL - 23, in this Phase 2 study for the treatment of PsA, was well tolerated with no unexpected safety findings in this patient population.2 Guselkumab is now being pursued in a Phase 3 development programme for psoriatic arthritis.

Not exact matches

Our data demonstrate the feasibility of targeted gene disruption in multiple rat strains within 4 months time, paving the way to a humanized monoclonal antibody platform and additional human disease models.

Weiner, Elliott and colleagues studied the DNA sequences for two human monoclonal antibodies — one able to broadly target influenza A viruses and one able to broadly target influenza B viruses — with collaborators at Inovio and MedImmune.

Studies of monkeys suggest injected ARVs might last 3 months, and human studies also are now examining long - acting monoclonal antibodies that target HIV.

The conserved membrane - proximal external region (MPER) of HIV - 1 gp41 is a target of the broadly neutralizing human monoclonal antibodies, 2F5 and 4E10.

Here we report the generation of aducanumab, a human monoclonal antibody that selectively targets aggregated Aβ.

Trastuzumab is a humanized monoclonal antibody that targets the HER2 receptor, which is overexpressed in approximately 20 — 30 % of human breast carcinomas [11].