The hypocretin receptor 2 gene could be the single most important gene in
human narcolepsy, says Michael Aldrich, a neurologist and director of the University of Michigan's Sleep Disorders Center.
Not exact matches
Although
narcolepsy appears to be genetically based in
humans, simply having the defective gene doesn't mean a person will have the disorder.
Although
humans with
narcolepsy do not possess the same genetic mutation, this finding still proved instrumental in unraveling the disease's fundamental cause.
That knowledge, coupled with evidence that
narcolepsy in
humans might be an autoimmune disorder, has led many researchers to suspect that sufferers have immune systems that are genetically predisposed to attack and destroy hypocretin - producing cells.
In the new work, the researchers added serum from Finnish
narcolepsy patients who had received Pandemrix to cells that were engineered to display
human hypo cretin receptor 2 on their surface.
In the early 1980s, scientists at the University of Tokyo found that all of their
narcolepsy patients had the same form of the
human leukocyte antigen, or HLA.
Amphetamines are also present in some medications used for weight loss and
narcolepsy in
humans.