Sentences with phrase «human neural stem cells»

They also replicated some of their testing in human neural stem cells in the lab, and noted the modern Zika virus killed more cells than an ancestral strain.

New Animal Model, Nanotechnologies and Neuroimaging to Study Interactions and Homing of Human Neural Stem Cells in Stroke.

Citation: Hester ME, Song S, Miranda CJ, Eagle A, Schwartz PH, Kaspar BK (2009) Two Factor Reprogramming of Human Neural Stem Cells into Pluripotency.

A current clinical trial investigating the use of transplanted human neural stem cells in Batten disease [67] will address questions concerning the safety of this cell type and provide important background for contemplating their clinical application in retinal disease.

A second research team injected human neural stem cells into the substantia nigras of 27 African green monkeys in which it had induced Parkinson's symptoms (including difficulty eating, tremors and stiffness).

They placed human neural stem cells in the rostral migration stream — a pathway in the rat brain that carries cells towards the olfactory bulb, which governs the animal's sense of smell.

Affiliation National Human Neural Stem Cell Resource, Children's Hospital of Orange County Research Institute, Orange, California, United States of America

Fetal human NSCs, isolated from the frontal brain cortex of a 28 week term fetus, (SCP - 27, P1) were obtained from the National Human Neural Stem Cell Resource (NHNSCR, Orange, CA).

Enhanced dopaminergic differentiation of human neural stem cells by synergistic effect of Bcl - xL and reduced oxygen tension

«Zika virus infects human neural stem cells.»

Confocal microscopy of human neural stem cell culture infected with Zika virus (red).

We also need to learn if the new connections formed by axons are stable over time, and if implanted human neural stem cells are maturing on a human time frame — months to years — or more rapidly.

Finally, the group examined human neural stem cells extracted from people with schizophrenia and found that these, too, showed higher levels of L1.

Researchers from the University of Cambridge studied a variety of cell lines, including human neural stem cells, to investigate how Zika virus infection can lead to microcephaly.

StemCells Inc. of Newark, California, reported encouraging results of an initial human trial using human neural stem cells to treat Pelizaeus - Merzbacher disease (PMD).

In one of the first studies that sheds light on exactly how Zika attacks, researcher Patricia Garcez of the Federal University of Rio de Janeiro took human neural stem cells and infected them with virus taken from a Brazilian patient.

And CRISPR has completely and utterly transformed the field, as we can do rapid gene targeting now in primary human neural stem cells.»

While previous studies had demonstrated a synergistic effect of BMP and LIF on the astrocytic differentiation of human neural stem cells [15], it remains unclear whether BMP and LIF induce distinct types of astrocytes and if so, what the functional properties of these astrocytes may be with respect to repairing CNS injuries.

A collaboration with the Roche pharmaceutical company led to the screening of 200 000 Roche compounds on human neural stem cells in order to identify proliferative drugs.

Finally, we used this approach to encapsulate human Neural Stem Cells (hNSC) derived from human Induced Pluripotent Stem Cells (hIPSC), which were further differentiated into neurons within the capsules with negligible loss of viability.

In a separate but related study, scientists this week also announced that they successfully reversed Parkinson - like symptoms in several monkeys by transplanting human neural stem cells into their brains.

But one glimpse came in 2013, when scientists transplanted human neural stem cells into the brains of mice which had damage in regions responsible for learning and memory.

They placed human neural stem cells in the rostral migration stream — a pathway in the rat brain that carries cells toward the olfactory bulb, which governs the animal's sense of smell.

Indeed, it has been demonstrated that LIF promotes self - renewal of human neural stem cells in vitro, though STAT signaling is insufficient to promote self - renewal in hESCs [24]--[26].

2 - D cell - culture and mouse experiments also provided key evidence of the virus's modus operandi; although the rodent brain doesn't harbor the full contingent of human neural stem cells, it has blood vessels and immune - system components that organoids lack.

Brazilian researchers from the D'Or Institute for Research and Education (IDOR) and Federal University of Rio de Janeiro (UFRJ) have demonstrated the harmful effects of ZIKA virus (ZIKV) in human neural stem cells, neurospheres and brain organoids.

Shah and his team induced toxin resistance in human neural stem cells and subsequently engineered them to produce targeted toxins.

The FDA recently approved the first clinical trial of a human neural stem cell therapy, developed by StemCells, a company in Palo Alto, California, to slow the progress of a fatal childhood neurodegenerative disorder called Batten disease.

Human neural stem cells are derived via fluorescence - activated cell sorting (FACS) from donated fetal brain tissue.

2) Human neural stem cells injected into MS mice stimulate the mouse's own cells to repair the damage.

Using human embryonic stem cells (hESC) characterized as carrying mutations associated with adult - onset disease during pre-implantation genetic diagnosis, we investigated the influence of human HTT and of an adult - onset HD mutation on mitotic spindle orientation in human neural stem cells (NSCs) derived from hESCs.

However, with the isolation of human embryonic stem cells and purification of human neural stem cells, it might be feasible to apply such strategies to human disease.

The inherent tumor - tropic properties of human neural stem cells (NSCs) can potentially be harnessed to overcome these obstacles and significantly improve cancer immunotherapy.