Sentences with phrase «human neurons»

This study was conducted in samples taken from rat brains, but sleep is thought to induce backward firing in human neurons, too.

The discovery allows this broad class of human neurons and their sensory mechanisms to be studied relatively easily in the laboratory.

The scientists also discovered that mouse models of PD didn't have the same abnormalities they found in human PD neurons, revealing the importance of studying human neurons to develop new therapies.

They applied their technique to produce human neurons by using iPSCs.

But no other group has used implanted electrodes to monitor so many human neurons at once or had such impressive results.

Fisher's team knew that FOXP2 turned other genes on and off in the brain, so they investigated human neurons grown in the lab to see which parts of the genome were bound by FOXP2 protein.

To form axon fascicles, the research teams manufactured a microdevice in which human neurons derived from induced pluripotent stem cells were injected.

In the study, published in the Proceedings of the National Academy of Sciences, the scientists used both rat neurons and human neurons created from induced pluripotent stem cells.

In this context, Dr. Woo's work focuses on deepening the understanding of these mechanisms based on postmortem human brains and animal studies using a variety of protein and gene expression techniques, in addition to the utilization of differentiated human neurons.

«But by using the latest stem - cell technology, we generated human neurons in a dish that exhibited the same pattern of cell degeneration and death that occurs inside a patient's brain.

These cells provide the starting material to produce human neurons and follow in real - time their maturation and connections into complex networks.

Using human neurons from Parkinson's patients, Krainc and colleagues identified a toxic cascade of mitochondrial and lysosomal dysfunction initiated by an accumulation of oxidized dopamine and a protein called alpha - synuclein.

But because the mice had human glia but not human neurons, he said, «we would have fewer concerns about any conceivable «humanization» of the mouse.»

The team has successfully turned a 0.5 - millimetre - thick section of human brain transparent, but working with larger chunks of human brain may be a challenge, as human neurons have a large amount of fatty protein surrounding their axons that must all be dissolved.

While it is not possible to dissect human neurons at such a level, the computer model performing a similar task is entirely transparent.

«Worms, mice, humans, and even fruit flies show similar effects of intoxication at similar alcohol concentrations,» he says, and human neurons contain a switch similar to that in C. elegans.

To model the neurons, we'd have to measure from them, but this turns out to be more difficult for C. elegans than for mouse or even human neurons.

The new human neurons were subsequently embedded in a matrix containing growth factors and grafted into two - week - old spinal cord injuries in rats.

The study, «Facilitation of axon regeneration by enhancing mitochondrial transport and rescuing energy deficits,» which has been published in The Journal of Cell Biology, suggests potential new strategies to stimulate the regrowth of human neurons damaged by injury or disease.

Because of the difficulties involved in harvesting and culturing adult human neurons, most research on DRG neurons has been done in mice.

The scientists further tested the function of these newly converted human neurons and found that, indeed, they were capable of both releasing and responding to neurotransmitters.

Her lab is using stem cells to study the function of the disease - causing gene and to generate human neurons suitable for transplantation and pharmacological screening.

GHOSH: We're learning a lot about development of normal human neurons, which would have been impossible previously, so there's a deep knowledge base in terms of understanding how cells mature and differentiate, how synapses behave, and perhaps circuits involving neurons behave.

Krainc and his colleagues showed this is due to differences in metabolism of dopamine between species, and underscored the importance of studying human neurons to discover new targets for drug development.

The second source, human neurons derived from the skin cells of LRRK2 - related Parkinson's patients, utilized the latest induced pluripotent stem cell (iPSC cell) technology.

Once the researchers identified these genes in yeast, they tested the human equivalents in human neurons, grown in a lab dish, that also overproduce alpha synuclein.

But the ethical consensus was that it might be okay if the fraction of human neurons in the mouse brain was so small that the implant had no chance of giving the mouse human consciousness or enhanced intelligence.

Cunningham and her postdoc at the time, Christine Kirvan, found that the antibodies literally bind to human neurons, activating an enzyme called calcium / calmodulin - dependent protein (CaM) kinase II.

This region is present in many human proteins, and a protein similar to ADR - 1 is specifically expressed in human neurons.

Cell culture systems used today also do not faithfully represent the features of human neurons.»

Researchers at the Salk Institute for Biological Studies recently found that the DNA sequence in human neurons can vary not only from that of the rest of the body but even from one brain cell to the next.

The researchers applied the approach to 3,377 mouse neurons and 2,784 human neurons, revealing 16 types of mouse neurons and 21 types of human neurons, each with a distinct pattern of methyl markings.

We seek to understand the molecular mechanisms underlying the development of healthy synapses as well as synaptic abnormalities in human neurons.

A future android brain like that of Star Trek's Commander Data might contain neuristors, multi-circuit components that emulate the firings of human neurons.

Recently, his lab used induced pluripotent stem (iPS) cells — adult cells made to act like embryonic stem cells — made from skin cells of patients carrying apoE4, or other mutations related to Alzheimer's, to study their effects on the development, survival, and degeneration of human neurons.

Capture of neuroepithelial - like stem cells from pluripotent stem cells provides a versatile system for invitro production of human neurons

«Our approach allowed us to grow human neurons in a dish that contained the exact same mutation as the neurons in the brain of the patient,» explained first author Helen Fong, PhD, who is also a California Institute for Regenerative Medicine postdoctoral scholar.

Building on Dr. Yamanaka's discoveries, Gladstone investigators who specialize in ALS have developed the first iPS - based, human neuron model of the disease, which they are now using both to evaluate potential pharmaceutical compounds to treat it, and to better understand how the disease progresses on a molecular level.

«Human neurons — derived from reengineered skin cells — could help assess the efficacy and safety of these drugs, thereby reducing risks and resources associated with human trials.»

«Because I'm interested in developing therapeutics, I need a system that generates billions of human neurons that have the particular mutations for this disease,» he says.

And on Feb. 24, Reuters reported that California scientists had used human stem cells to create human neurons in mouse brains.

Using CRISPR genome editing in human neurons, Krogan's team will delete all 600 genes, one by one as well as in combination, to determine how each one affects the neurons» health.

B is better than AAV9 at delivering genes to human neurons and glia.

«By surmounting major challenges in human neuron - based drug discovery, we believe this technique will be adopted widely in both basic science and industry.»

The researchers confirmed that, in human neurons, the misshapen apoE4 protein can not function properly and is broken down into disease - causing fragments in the cells.

Human neurons differentiated from skin - derived stem cells.