Targeting, Endocytosis, and Lysosomal Delivery of Active Enzymes to Model
Human Neurons by ICAM -1-Targeted Nanocarriers.
Not exact matches
nothing makes the atheist more ticked off more than when you bring up GOD... God gets all the blame for all the tragedy in the world... If there wasnt a god in the first place,
humans would not know tragedy or injustice when we see it... it would be a non-issue to us... survival of the fittest would not permit the emotions of love, compassion, empathy... Darwininian theory could not allow any of those and many other of the best of people's capacity for caring to surface... You cant explain it away
by synapse or
neurons... without a Supreme Being, there would be no sense of justice or injustice, we would not call it anything because there is no Ultimate Moral Standard to compare it.
Panksepp saw that
human emotions and emotional problems could be explored
by studying other mammals — how their brains generated emotions akin to the anger, sadness and joy that
humans describe, what
neurons and neural circuits were involved.
USING YOUR BRAIN In «The Limits of Intelligence,» Douglas Fox points out that
human intelligence is limited
by communication among
neurons in the brain, which is limited in turn
by the size of our
neurons.
Oliver Brüstle, director of the Institute of Reconstructive Neurobiology at the University of Bonn, Germany, who had a patent on a method for generating
neurons from
human embryonic stem cells rejected
by the court, called the ruling «the worst possible outcome», and «a disaster for Europe».
Researchers at Geron, meanwhile, had successfully derived
neurons from
human embryonic stem cells and were pursuing research that would eventually look to repair the damage caused
by spinal - cord injuries, a possible use for embryonic stem cells that was much touted at the time.
When the researchers compared the mRNA to a library of DNA sequences taken from the dendrites of
neurons by James Eberwine of the University of Pennsylvania Medical Center, they found that it came from a single gene on chromosome X — the
human version of which, when mutated, leads to fragile - X syndrome.
By tapping existing compounds known to block one class of olfactory
neurons, scientists might be able to better camouflage
humans from mosquito detection or draw mosquitoes away from
humans with chemical bait.
The agency supports network science through individual institutes (for example, the National Institute of General Medical Sciences funds nine National Centers for Systems Biology, academic centers that emphasize network biology) and through agencywide initiatives (such as the National Technology Centers for Networks and Pathways, funded
by the NIH Roadmap for Medical Research and the recently announced
Human Connectome Project, which aims to map the connections among the human brain's 100 billion neur
Human Connectome Project, which aims to map the connections among the
human brain's 100 billion neur
human brain's 100 billion
neurons).
We know that in the
human brain there are about one hundred billion
neurons that communicate
by means of electrical signals.
Researchers have identified the
neurons in monkeys that are dampened
by scratching, a finding that could lead to new ways of alleviating itching in
humans.
85 Billion Estimated number of cells in the
human brain that are not
neurons, according to a 2009 study
by Brazilian neuroscientists.
That is, when you don't stimulate it, the whole population of
neurons stray back and forth, as has been described
by scientists in
human beings who aren't thinking of anything.
The ~ 200 GB of data for each brain was then analyzed with machine learning algorithms that identify individual
neurons by type, according to parameters «learned» from
human experts.
By the time
humans are born, most of their subplate
neurons have already disappeared.
A unique form of carbon dating, made possible
by the Cold War, suggests that new
neurons rarely survive in the
human olfactory bulb after birth
A postmortem analysis of
human brain tissue, for example, conducted
by Witelson and her colleagues at the Michael G. DeGroote School of Medicine at McMaster, revealed that women's
neurons were 11 percent denser than men's in the prefrontal cortex and in a region of the temporal cortex that is involved with language processing, comprehension, and memory.
This, Gather says, would make it easier to develop direct
human - to - machine interfaces, in which a brain's
neurons signal their operation with flashes of laser light, to be captured
by an exterior device.
The processors — modeled after the brain's networks of
neurons — are first trained
by humans on actual translations and then let loose on new sets of data.
Rather, Verkhratsky argues, the apparent advantages afforded
by human astrocytes may be a consequence of their housekeeping abilities, underscoring the interdependence between glia and
neurons.
They also applied it to
human brain tissue collected
by the Genotype - Tissue Expression (GTEx) Project, finding that they could a) identify expression signatures unique to
neurons, glial cells, and other cell types in the brain (including rare types), and b) differentiate between closely related cell subtypes.
By pairing a receptor that targets
neurons with a molecule that degrades the main component of Alzheimer's plaques, the biologists were able to substantially dissolve these plaques in mice brains and
human brain tissue, offering a potential mechanism for treating the debilitating disease, as well as other conditions that involve either the brain or the eyes.
The results obtained
by Afsaneh Gaillard's team and that Pierre Vanderhaeghen at the Institute of Interdisciplinary Research in
Human and Molecular Biology show, for the first time, using mice, that pluripotent stem cells differentiated into cortical
neurons make it possible to reestablish damaged adult cortical circuits, both neuroanatomically and functionally.
The new study — published October 18, 2016 in the journal Molecular Psychiatry — combined genetic analysis of more than 9,000
human psychiatric patients with brain imaging, electrophysiology, and pharmacological experiments in mutant mice to suggest that mutations in the gene DIXDC1 may act as a general risk factor for psychiatric disease
by interfering with the way the brain regulates connections between
neurons.
The virtual world used in the study was very similar to virtual reality environments used
by humans, and
neurons in a rat's brain would be very hard to distinguish from
neurons in the
human brain, Mehta said.
Because neurogenesis surges in newborn mice and
humans and then tapers to a slow trickle
by adulthood, Frankland and colleagues wondered if that explosion of new
neurons could help explain the widespread phenomenon of infantile amnesia — the inability of adults to remember events that occurred before they were 2 to 4 years old.
Thus,
by monitoring the activity of motion - detecting
neurons in animals and simultaneously exploring
human motion perception using cunningly contrived displays such as a, b and c, scientists are starting to understand the mechanisms in your brain that are specialized for seeing motion.
The study, published Feb. 16 in PLOS Biology, made use of a mutant zebrafish strain that models
human Hirschsprung disease, which is caused
by loss of the gut
neurons that coordinate gut contractions.
Scientists at McMaster University have discovered how to make adult sensory
neurons from
human patients simply
by having them roll up their sleeve and providing a blood sample.
In a new study, published 11 August in Science, researchers classified
neurons from mouse and
human brain tissue
by their methylation patterns.
The three - year study conducted
by McLean researchers points to specific neuroanatomical changes in
human subjects with these illnesses, and specifically to
neurons that regulate anxiety and stress response, according to Harry Pantazopoulos, PhD, assistant neuroscientist at McLean's Translational Neuroscience Laboratory and instructor in psychiatry at Harvard Medical School.
It is possible that
by promoting neurogenesis via sustained aerobic exercise, the
neuron reserve of the hippocampus can be increased and thus also the preconditions for learning improved — also in
humans.
The study, «Facilitation of axon regeneration
by enhancing mitochondrial transport and rescuing energy deficits,» which has been published in The Journal of Cell Biology, suggests potential new strategies to stimulate the regrowth of
human neurons damaged
by injury or disease.
Though their purpose and function are still largely unknown, mirror
neurons in the brain are believed
by some neuroscientists to be central to how
humans relate to each other.
A supercharged microprocessor Each of the 100 billion
neurons in the
human brain is an elaborate processor powered
by neurotransmitters.
Recent research
by neuroscientist Fred Gage and colleagues at the University of California (UC), San Diego, has shown that one of the most common types of jumping gene in people, called L1, is particularly abundant in
human stem cells in the brain that ultimately differentiate into
neurons and plays an important role in regulating neuronal development and proliferation.
This brain slice from a
human autopsy has taken on vivid color in the hands of a neuroscientist: green from infection
by a lentivirus, red for
neurons, blue for the nuclei of brain cells.
«If we can find a way to target those
neurons in
humans, maybe we can reduce the «high» produced
by the drug and reduce the withdrawal symptoms,» said Olivier George, assistant professor at TSRI and senior author of the new study.
Using mouse and
human - derived dopamine
neurons, researchers found that dopamine movement is affected
by changes in electrical properties of the
neurons.
Now, for the first time, a team of scientists led
by Professor Simon Schultz and Dr Luca Annecchino at Imperial College London has developed a robot and computer programme that can guide tiny measuring devices called micropipettes to specific
neurons in the brains of live mice and record electrical currents, all without
human intervention.
Scientists working to develop new treatments for neurodegenerative diseases have been stymied
by the inability to grow
human motor
neurons in the lab.
More than 50 years later, scientists have found a way to use radioactive carbon isotopes released into the atmosphere
by nuclear testing to settle a long - standing debate in neuroscience: Does the adult
human brain produce new
neurons?
Past work
by Yoo and his colleagues — then at Stanford University — showed that exposure to two short snippets of RNA turned
human skin cells into
neurons.
In
humans, deafness is most often caused
by damage to inner ear hair cells — so named because they sport hairlike cilia that bend when they encounter vibrations from sound waves — or
by damage to the
neurons that transmit that information to the brain.
The now abundant, remade microglia multiplied
by 70 percent after one week and selectively cleared accumulated
human TDP - 43 from motor
neurons.
For instance, the difference in intelligence between an individual with, say, a brain that's 1,100 grams and one that's 1,400 grams (which could be found in
humans) is confounded
by other variables, including differences in density of
neurons, other structural brain differences and socio - cultural factors.
In the same way that the fly genome paved the way for larger projects, including sequencing the
human genome, FlyEM may ultimately contribute to our understanding of the
human brain
by establishing a fly «connectome» — a map that shows how all
neurons in the fly brain are connected to each other.
by Paroma Basu Scientists grow critical nerve cells MADISON, WI — January 31, 2005 — After years of trial and error, scientists have coaxed
human embryonic stem cells to become spinal motor
neurons, critical nervous system pathways that relay messages from the brain to the rest of the body.
Although the
human cells became glial cells (the brain's scaffolding) and not
neurons, the mice unexpectedly became four times as smart as regular mice, as measured
by how well they ran mazes and other tests.
Sitting
by himself in the lab, late at night, he stared at the screen of the oscilloscope he used to track the
neurons» electrical fluctuations, becoming the first
human to witness memories being physically written on the brain.