Not exact matches
HDAC5 is found in high amounts in neurons in the
nucleus accumbens, part of the reward center of the brain that reacts strongly to cocaine, opioids and alcohol — both in rodents and
humans.
The experiments highlighted an area of the brain known as the «
nucleus accumbens», which has been long - associated with motivation, reward and depression — in
humans too.
Although brain - imaging studies of
human participants watching funny cartoons or listening to jokes reveal the activation of evolutionarily ancient structures such as the amygdala and
nucleus accumbens, more recently evolved, «higher - order» structures are also activated, including distributed regions of the frontal cortex.
Indeed, in
humans, imaging studies have shown that drugs of abuse increase DA release in striatum (including the
nucleus accumbens), and these increases have been associated with the subjective experience of reward (7 ⇓ — 9).