Sentences with phrase «human obesity such»

Obesity in these mice resembles several important clinical features of human obesity such as weight gain and disturbance of metabolism, and this mouse model was ideal for unraveling any underlying biological mechanisms of pancreas cancer that are put in motion by obesity.

Not exact matches

Such was the case when a dozen fourth and fifth graders posed a few hard - hitting questions to Health and Human Services Secretary Kathleen Sebelius, Education Secretary Arne Duncan and Agriculture Secretary Tom Vilsack, who are all now part of President Barack Obama's new federal task force to combat childhood obesity.

In humans, too much fructose puts the liver at risk for conditions such as fatty liver disease, and raises the overall risk of obesity and type 2 diabetes (SN: 10/5/13, p. 18).

The discovery could shed light on why many human genetic studies have previously not been able to fully explain how certain diseases, such as type 2 diabetes and obesity, are inherited.

Even seemingly intractable problems such as the antibiotic crisis and the obesity epidemic could be resolved by treating human health and society as an integral part of an ecosystem.

«The addition of osteocalcin as a metabolic regulator may one day lead to novel therapies, but we need to understand much better how it works and how it fits into physiology before such therapies can be attempted in humans,» says endocrinologist Mitch Lazar, director of the Institute for Diabetes, Obesity, and Metabolism at the University of Pennsylvania.

Mice have proven to be a particularly good model for studies relevant to humans, Magnusson said, on such topics as aging, spatial memory, obesity and other issues.

«Preclinical evidence suggests that dietary interventions, such as calorie restriction, intermittent fasting, low - fat diet and the ketogenic diet, have the potential to reverse some of these obesity - associated alterations; however, more clinical data are needed to confirm translation to human subjects.»

Using cells from mice and human livers, Toronto General Hospital Research Institute researchers demonstrated for the first time how under specific conditions, such as obesity, liver CD8 + T cells, white blood cells which play an important role in the control of viral infections, become highly activated and inflammatory, reprogramming themselves into disease - driving cells.

Dysfunctional microbiomes are associated with issues including human chronic diseases such as obesity, diabetes, and asthma; local ecological disruptions such as the hypoxic zone in the Gulf of Mexico; and reductions in agricultural productivity.

Dr. Nobrega has modeled the impact of mutations implicated in various human diseases, such as congenital heart defects, heart failure, cancer, type 2 diabetes, obesity, and asthma.

Obesity, through its co-morbidities such as diabetes, lipid disorders, and hypertension, contributes greatly to human disease.

Such leptin resistance may translate into diseases, notably it could be responsible for obesity in humans who have high levels of leptin.

There is also now abundant research that links BPA and phthalate exposure to such human health concerns as deformities of the male and female genitals; premature puberty in females; decreased sperm quality; and increases in breast and prostate cancers, infertility, miscarriages, obesity, type 2 diabetes, allergies and neurological problems, like attention deficit hyperactivity disorder.

He taught me a lot about evolutionary medicine and nutrition in general, opened many doors and introduced me (directly and indirectly) to various players in this field, such as Dr. Boyd Eaton (one of the fathers of evolutionary nutrition), Maelán Fontes from Spain (a current research colleague and close friend), Alejandro Lucia (a Professor and a top researcher in exercise physiology from Spain, with whom I am collaborating), Ben Balzer from Australia (a physician and one of the best minds in evolutionary medicine), Robb Wolf from the US (a biochemist and the best «biohackers I know»), Óscar Picazo and Fernando Mata from Spain (close friends who are working with me at NutriScience), David Furman from Argentina (a top immunologist and expert in chronic inflammation working at Stanford University, with whom I am collaborating), Stephan Guyenet from the US (one of my main references in the obesity field), Lynda Frassetto and Anthony Sebastian (both nephrologists at the University of California San Francisco and experts in acid - base balance), Michael Crawford from the UK (a world renowned expert in DHA and Director of the Institute of Brain Chemistry and Human Nutrition, at the Imperial College London), Marcelo Rogero (a great researcher and Professor of Nutrigenomics at the University of Sao Paulo, Brazil), Sérgio Veloso (a cell biologist from Portugal currently working with me, who has one of the best health blogs I know), Filomena Trindade (a Portuguese physician based in the US who is an expert in functional medicine), Remko Kuipers and Martine Luxwolda (both physicians from the Netherlands, who conducted field research on traditional populations in Tanzania), Gabriel de Carvalho (a pharmacist and renowned nutritionist from Brazil), Alex Vasquez (a physician from the US, who is an expert in functional medicine and Rheumatology), Bodo Melnik (a Professor of Dermatology and expert in Molecular Biology from Germany, with whom I have published papers on milk and mTOR signaling), Johan Frostegård from Sweden (a rheumatologist and Professor at Karolinska Institutet, who has been a pioneer on establishing the role of the immune system in cardiovascular disease), Frits Muskiet (a biochemist and Professor of Pathophysiology from the Netherlands, who, thanks to his incredible encyclopedic knowledge and open - mind, continuously teaches me more than I could imagine and who I consider a mentor), and the Swedish researchers Staffan Lindeberg, Tommy Jönsson and Yvonne Granfeldt, who became close friends and mentors.

In human patients, insulin resistance is largely the result of genotype but is worsened by environmental factors such as obesity (21,29).

An inadequate diet and sharing human food can lead to a number of complications such as allergic reactions, toxicity, and obesity.

Comparative medicine, which explores the similarities between human and animal conditions such as heart disease, cancer, and obesity, is also a One Health subject.