And they found that blood serum obtained following the consumption of an almond meal inhibits
human osteoclast formation, function, and gene expression, providing direct evidence to support the association between regular almond consumption and a reduced risk of developing osteoporosis.
Further experimentation in vitro with
human osteoclasts and in vivo in mice identified a portion of the Del - 1 protein that was particularly important for containing osteoclast activity, though additional parts of the molecule were needed to have the most potent inhibition of inflammation and bone loss.
Not exact matches
Denosumab, a fully
human monoclonal antibody drug, binds specifically to RANK - ligand (RANKL) and inhibits
osteoclast - induced bone resorption by preventing the binding of RANKL to RANK.
They found evidence of Del - 1 in the same areas as
osteoclast activity, then followed up by generating
human and mouse
osteoclasts in vitro and found Del - 1 mRNA and protein expressed at high levels.
To investigate the underlying mechanisms, we undertook (1) bioinformatic, functional genomic annotation and
human osteoblast expression studies; (2) gene - function prediction; (3) skeletal phenotyping of 120 knockout mice with deletions of genes adjacent to lead independent SNPs; and (4) analysis of gene expression in mouse osteoblasts, osteocytes and
osteoclasts.