Sentences with phrase «human ovarian»

In an interdisciplinary collaboration, the University of Pennsylvania School of Veterinary Medicine's Working Dog Center (photo above courtesy of University of Pennsylvania), the School of Arts and Science's Department of Physics and Astronomy, Penn Medicine's Division of Gynecologic Oncology, and the Monell Chemical Senses Center have joined together for a research investigation using canine olfaction, along with chemical and nanotechnology analysis, to detect early - stage human ovarian cancer.

ab51608 staining HIF -1-alpha in Human ovarian carcinoma tissue sections by Immunohistochemistry (IHC - P - paraformaldehyde - fixed, paraffin - embedded sections).

Matsuzaki J, Gnjatic S, Mhawech - Fauceglia P, Beck A, Miller A, Tsuji T, Eppolito C, Qian F, Lele S, Shrikant P, Old LJ, Odunsi K. (2010) NY - ESO - 1 specific tumor infiltrating CD8 + T cells in human ovarian cancer: negative regulation by LAG - 3 and PD - 1.

PD - 1 and CD103 Are Widely Coexpressed on Prognostically Favorable Intraepithelial CD8 T Cells in Human Ovarian Cancer.

Interference with actin dynamics is superior to disturbance of microtubule function in the inhibition of human ovarian cancer cell motility.

Induction of autophagy contributes to cisplatin resistance in human ovarian cancer cells.

Epigenetic potentiation of NY - ESO - 1 vaccine therapy in human ovarian cancer.

In another set of experiments, the team implanted human ovarian carcinoma cells into mice.

To test this in a treatment situation, Peter collaborated with Dr. Shad Thaxton, associate professor of urology at Feinberg, to deliver the assassin molecules via nanoparticles to mice bearing human ovarian cancer.

The research, «Synchrotron X-Ray Fluorescence Nanoprobe Reveals Target Sites for Organo - Osmium Complex in Human Ovarian Cancer Cells», is published in Chemistry — A European Journal.

Combining chemotherapy and birinapant significantly improved disease - free survival in laboratory models of human ovarian cancer compared to using either therapy alone.

Sood and colleagues looked at samples from 80 cases of human ovarian cancer grouped according to patient stress using the National Institutes of Health's Center for Epidemiological Studies Depression scale as a surrogate marker.

Sood and his team first studied the effects of stress hormones on human ovarian cancer cell anoikis in culture.

The scientists found that, at certain concentrations, one of the compounds of the series selectively killed human ovarian cancer cells without harming healthy cells.

As proof - of - principle of the potential efficacy, Zhang's team grew human ovarian tumors in immunocompromised mice, then injected short - interfering RNAs to block the tumors» growth using RNA interference against FAL1.

When the team assessed FAL1 expression in human ovarian cancer samples, they found that high FAL1 expression tended to correlate with poor clinical prognosis.

So his team looked for cells with vasa still on their surface in human ovarian tissue.

This was observed in human ovarian cancer cells grown in culture, and then in mouse models of the disease.

One paper describes cryopreservation of human ovarian cortex tissues.

Shih, Wang and their colleagues tested fostamatinib's power to reduce tumor size in mice implanted with human ovarian cancer cells that were resistant to paclitaxel.

Hsueh's team has used a similar approach to stimulate fragments of human ovarian tissue.

Not exact matches

As humans, we've developed ways to donate blood, tissue, organs, and even sperm and ovarian eggs in recent generations, but human milk has been shared since women began having babies.

Additionally, the U.S. Department of Health and Human Services finds that women who breastfeed their babies probably lower their risk for developing breast cancer, type 2 diabetes, ovarian cancer, postpartum depression, and rheumatoid arthritis.

Rodriguez wondered if the same association might exist in humans, so she analyzed ovarian cells from women undergoing in vitro fertilization at Johns Hopkins» infertility clinic.

In the paper, published in the now - defunct online journal e-biomed, West, Lanza and their colleagues showed that they could pull a nucleus from a human egg cell, replace it with a whole adult ovarian cell and generate an embryo that divided into six cells.

So he implanted various human tumors — including ovarian, breast, colon, liver, and brain — into mice and then injected the animals with antibodies that disable CD47.

Tiny particles bring deadly rain Nanobacteria have been implicated in human diseases from clogged arteries to ovarian cancer.

Then the researchers turned to the lab, where they exposed human liver, breast, colon, ovarian, and other cancer cells to the drugs, which appeared to make it easier for the cells to migrate.

Beyond lung cancer, TiY is able to target TICs in 28 types of human cell lines derived from the central nervous system, melanoma, breast, renal, ovarian, colon, and prostate cancer.

The discovery sheds new light on our understanding of the genetic complexity underpinning variations in human pigmentation, and could advance our knowledge of conditions linked to pigmentation, such as skin, testicular, prostate and ovarian cancers.

In addition to the afatinib - resistant NSCLC cells, the researchers tested the neratinib and valproic acid combination on cell lines derived from human pancreatic and ovarian cancers containing K - Ras mutations and N - Ras mutations, respectively.

Nagrath, director of Rice's Laboratory for Systems Biology of Human Diseases, said the new metabolic analysis indicates that ovarian cancer may be susceptible to multidrug cocktails, particularly if the amounts of the drugs can be tailored to match the metabolic profile of a patient's tumor.

A HUMAN ovary grown in the lab from slivers of ovarian tissue has been able to turn an immature egg into one that is ready to be fertilised.

The program works by connecting computer - generated drug profiles — including mechanisms of action, clinical efficacy, and side effects — with information about how a molecule may interact with human proteins in specific diseases, such as ovarian cancer.

Researchers at Rice University's Laboratory for Systems Biology of Human Diseases analyzed the metabolic profiles of hundreds of ovarian tumors and discovered a new test to determine whether ovarian cancer cells have the potential to metastasize.

The team began by identifying hundreds of genes frequently mutated in human cancers: 200 implicated in breast cancer, 170 linked to ovarian cancer, and 134 involved in DNA repair, which is compromised in many types of cancer.

The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response of breast and ovarian tumor cells to common classes of chemotherapy treatment.

In humans, colon cancer often spreads to the liver and forms small tumors that are difficult to detect, similar to ovarian tumors.

As recent data suggest, PSMA is an important cancer antigen expressed on many human prostate, bladder, renal as well as ovarian cancers, so additional study of the possible benefits of this therapy are important.»

If you believe, for example, that granulosa cells and other very early features of ovarian ecology set up the polarities that ultimately determine the quality of a human egg, as Albertini does, then certain techniques widely used in IVF may be subtly perturbing the very mechanisms that eggs use to establish a plan to build an embryo and maximize the chances that it will develop properly.

Female rats exposed in the womb to high doses of several chemicals — including pesticides and plasticizers — developed cysts resembling human polycystic ovarian syndrome and premature menopause, according to the study published in PLoS One in July.

In the test tube, the nanogenerators killed leukaemia, lymphoma, breast, ovarian, neuroblastoma, and prostate human cancer cells.

The authors studied a standard panel of 60 established human tumor cell lines representing nine different human cancers, as well as several specimens of human primary ovarian cancer.

In addition to the inherited breast and ovarian cancer, her research interests include genetics of hearing loss, the genetic bases of schizophrenia, genetics of systemic lupus erythematosus, and human genetic diversity and evolution.

The Xie Lab demonstrated that differentiation - defective Drosophila ovarian germline stem cells (GSCs), behaving like human cancer stem cells, can out - compete normal stem cells for a position in the niche.

Ovarian Cancer: CXCR4 is overexpressed in human advanced and metastatic ovarian Ovarian Cancer: CXCR4 is overexpressed in human advanced and metastatic ovarian ovarian cancer.

Biological Function of Ribosomal Protein L10 on Cell Behavior in Human Epithelial Ovarian Cancer Jimin Shi, Lingyun Zhang, Daibing Zhou, Jinguo Zhang, Qunbo Lin, Wencai Guan, Jihong Zhang, Weimin Ren, Guoxiong Xu J. Cancer 2018; 9 (4): 745 - 756.

December 17, 2013 Cancer genetics pioneer Janet Rowley, 1925 - 2013 A pioneer in connecting the development of cancer with genetic abnormalities, Janet D. Rowley, MD, the Blum - Riese Distinguished Service Professor of Medicine, Molecular Genetics & Cell Biology and Human Genetics at the University of Chicago, died from complications of ovarian cancer on December, 17, 2013, at her home.

Fast - forward two decades and what do we really know about these two human genes and their connection to ovarian and breast cancers?

Building on 30 years of research, this achievement outlines three fundamental steps that successfully took ovarian tissue samples and nurtured them into human eggs to a point of full maturity.