As proof - of - principle of the potential efficacy, Zhang's team grew
human ovarian tumors in immunocompromised mice, then injected short - interfering RNAs to block the tumors» growth using RNA interference against FAL1.
Not exact matches
Shih, Wang and their colleagues tested fostamatinib's power to reduce
tumor size in mice implanted with
human ovarian cancer cells that were resistant to paclitaxel.
So he implanted various
human tumors — including
ovarian, breast, colon, liver, and brain — into mice and then injected the animals with antibodies that disable CD47.
Nagrath, director of Rice's Laboratory for Systems Biology of
Human Diseases, said the new metabolic analysis indicates that
ovarian cancer may be susceptible to multidrug cocktails, particularly if the amounts of the drugs can be tailored to match the metabolic profile of a patient's
tumor.
Researchers at Rice University's Laboratory for Systems Biology of
Human Diseases analyzed the metabolic profiles of hundreds of
ovarian tumors and discovered a new test to determine whether
ovarian cancer cells have the potential to metastasize.
The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple
human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response of breast and
ovarian tumor cells to common classes of chemotherapy treatment.
In
humans, colon cancer often spreads to the liver and forms small
tumors that are difficult to detect, similar to
ovarian tumors.
The authors studied a standard panel of 60 established
human tumor cell lines representing nine different
human cancers, as well as several specimens of
human primary
ovarian cancer.
Matsuzaki J, Gnjatic S, Mhawech - Fauceglia P, Beck A, Miller A, Tsuji T, Eppolito C, Qian F, Lele S, Shrikant P, Old LJ, Odunsi K. (2010) NY - ESO - 1 specific
tumor infiltrating CD8 + T cells in
human ovarian cancer: negative regulation by LAG - 3 and PD - 1.
Tags: AACR 2017, aacr 2018, Breast Cancer, Christopher J Kemp, Clinical Research, Colorectal Cancer, Eddie Mendez, genomics, head neck cancers,
Human Biology,
Ovarian Cancer, Pancreatic Cancer, precision medicine, Public Health Sciences, solid
tumors, uterine cancer, Vijayakrishna Gadi
Human Warnings: Carcinogenesis: Nitrofurazone has been shown to produce mammary
tumors in rats and
ovarian tumors in mice.