Sentences with phrase «human platelets»

"Human platelets" refers to small cells in our blood that help with clotting, stopping bleeding when we get cut or injured. Full definition
David Kaplan, Ph.D., professor and Director of the NIH P41 Resource Center on Tissue Engineering, Alessandra Balduini, M.D., and their collaborators have focused on forming bone marrow models with these components and other growth factors to imitate and support the formation of functional human platelets.
The findings, published April 28 in Cell Metabolism, are the first comprehensive lipidomic profile of human platelets in response to stimulation and aspirin treatment.
DG041 is a novel, first - in - class, orally - administered small molecule which has been shown in preclinical studies to be a selective and potent antagonist of the EP3 receptor for prostaglandin E2 (PGE2), inhibiting human platelet aggregation in a dose - dependent manner.
In preclinical in vitro studies DG041 has been shown to inhibit human platelet aggregation induced by PGE2, and to do so in a dose - dependent manner.
The group also studied human platelets with a similar sugary disguise.
Researchers funded by the National Institute of Biomedical Imaging and Bioengineering at Tufts University and their collaborators have successfully developed a 3 - dimensional (3D) tissue - engineered model of bone marrow that can produce functional human platelets outside the body (ex vivo).
Protease - activated receptor (PAR) 1 and PAR4 differentially regulate factor V expression from human platelets.
The team first pre-screened human platelets to narrow the field of drug - like compounds, then generated an activity - based protein profile using one of these compounds to single out proteins that play a role in platelet activation.
Co-author, «Pathway for the Formation of D - 3 Phosphate Containing Inositol Phospholipids in Intact Human Platelets,» The Journal of Biological Chemistry, December 1990
A team led by researchers at the Tufts University School of Engineering and the University of Pavia has reported development of the first three - dimensional tissue system that reproduces the complex structure and physiology of human bone marrow and successfully generates functional human platelets.
Top, the bioreactor that can make fully functional human platelets.
A team led by researchers at Tufts University School of Engineering and the University of Pavia has reported development of the first three - dimensional tissue system that reproduces the complex structure and physiology of human bone marrow and successfully generates functional human platelets.
«This is an elegant example of how to deconstruct a complex process into its basic elements, and then build it back up, brick by brick, to give you a basic structure you need for the product you are looking for — in this case a human platelet made to order,» said Rosemarie Hunziker, PhD, program director of Tissue Engineering at NIBIB.
A new study — the first to apply a new screening technique to human platelets — netted a potential drug target for preventing dangerous blood clots in high - risk people.
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