Not exact matches
Introducing
human prostate cancer cell lines into mice, Wu and his colleagues saw a particular enzyme called MAOA activate a cascade of signals that made it easier for
tumor cells to invade and grow in bone.
They also tested other
cancer lines —
human cervical, lung and
prostate cancers — and found that they responded to the patterned
tumor environments in the same way.
Further research uncovered a broad spectrum of cell surface stem cell markers (e.g., CD133, CD44, and CD24) that allow the identification of CSCs in
human solid
tumors, including brain, breast,
prostate, pancreas, liver, ovary, skin, colon
cancers, and melanoma (3 - 6)(Figure 1 based on 7).
Although persistent loss of IGF - 1R expression ultimately induced cell stasis and death, both of these processes are regulated by the
tumor suppressor gene p53 that is commonly mutated in
human prostate cancers.
Tags: Acute Myeloid Leukemia, Andrew Hsieh, Basic Sciences, Clinical Research, Harmit Malik,
Human Biology, Jesse Bloom, Marie Bleakley,
Prostate Cancer, Transplant and Immunotherapy,
Tumor specific translational research, Vaccine development - Viral
cancers
In a series of lab experiments with cell lines,
human xenograft
tumors in mice and primary
human prostate cancer samples, the researchers demonstrated that miR - 34a inhibits
prostate cancer stem cells by suppressing CD44.
Important features of XMRV biology include (1) tropism for a variety of cell lines, including
prostate cancer DU145 and LNCaP cells [27], [43], [48], and
human neural cell types [57], (2) adaptations that promote growth in
prostate epithelium and
human - derived
prostate cancer cell lines including an androgen response element in the promoter region [58] and downregulation of APOBEC3G [59], and (3) cellular effects with potential oncogenic properties including increased
tumor aggressiveness mediated by downregulation of p27 [60] and differential regulation of several microRNAs [61].
The most frequent
tumors in
human —
cancer of the colon, breast, lung, and
prostate — all involve mutations in
tumor suppressor genes.
Still, by the 1990s DuPont knew that the chemical caused cancerous
tumors in the testes, pancreases, and livers of lab animals, and there was even evidence of
human DNA damage and links to
prostate cancer in workers exposed to PFOA.
Phytates have been shown to inhibit the growth of
human leukemia cells, colon
cancer cells, both estrogen receptor - positive and negative breast
cancer cells, voicebox
cancer, cervical
cancer,
prostate cancer, liver
tumors, pancreatic, melanoma, and muscle
cancers.