Sentences with phrase «human prostate tumor»

Coffin described how lab workers there had transplanted human prostate tumor cells into an immune - deficient lab mouse, a common procedure for procuring a colony of cells, or a human cell line, for further study.

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Researchers have injected mice with human breast, ovary, colon, bladder, brain, liver and prostate tumors, and their new drug has killed the tumors every time.

Capsaicin additionally produced a significant deceleration of the development of prostate tumors created simply by those human cell lines grown in mouse models.

Introducing human prostate cancer cell lines into mice, Wu and his colleagues saw a particular enzyme called MAOA activate a cascade of signals that made it easier for tumor cells to invade and grow in bone.

They also tested other cancer lines — human cervical, lung and prostate cancers — and found that they responded to the patterned tumor environments in the same way.

Using cultured cells derived from human tumors of the breast and prostate gland, they confirmed that the IL6R / STAT3 / miR -34 a feedback loop is also activated in other tumor types.

Almost 10 years to the day after the human genome sequence was completed, a group of researchers has unveiled the first whole genome sequences of prostate tumors.

Further research uncovered a broad spectrum of cell surface stem cell markers (e.g., CD133, CD44, and CD24) that allow the identification of CSCs in human solid tumors, including brain, breast, prostate, pancreas, liver, ovary, skin, colon cancers, and melanoma (3 - 6)(Figure 1 based on 7).

Although persistent loss of IGF - 1R expression ultimately induced cell stasis and death, both of these processes are regulated by the tumor suppressor gene p53 that is commonly mutated in human prostate cancers.

Tags: Acute Myeloid Leukemia, Andrew Hsieh, Basic Sciences, Clinical Research, Harmit Malik, Human Biology, Jesse Bloom, Marie Bleakley, Prostate Cancer, Transplant and Immunotherapy, Tumor specific translational research, Vaccine development - Viral cancers

In a series of lab experiments with cell lines, human xenograft tumors in mice and primary human prostate cancer samples, the researchers demonstrated that miR - 34a inhibits prostate cancer stem cells by suppressing CD44.

Flavopiridol inhibits several cellular kinases and has demonstrated cytostatic and cytotoxic activity in vitro and in vivo in numerous human tumor cell lines and xenograft models (including human breast, prostate, and lung carcinoma) at clinically achievable concentrations.

Important features of XMRV biology include (1) tropism for a variety of cell lines, including prostate cancer DU145 and LNCaP cells [27], [43], [48], and human neural cell types [57], (2) adaptations that promote growth in prostate epithelium and human - derived prostate cancer cell lines including an androgen response element in the promoter region [58] and downregulation of APOBEC3G [59], and (3) cellular effects with potential oncogenic properties including increased tumor aggressiveness mediated by downregulation of p27 [60] and differential regulation of several microRNAs [61].

The most frequent tumors in human — cancer of the colon, breast, lung, and prostate — all involve mutations in tumor suppressor genes.

Still, by the 1990s DuPont knew that the chemical caused cancerous tumors in the testes, pancreases, and livers of lab animals, and there was even evidence of human DNA damage and links to prostate cancer in workers exposed to PFOA.

Phytates have been shown to inhibit the growth of human leukemia cells, colon cancer cells, both estrogen receptor - positive and negative breast cancer cells, voicebox cancer, cervical cancer, prostate cancer, liver tumors, pancreatic, melanoma, and muscle cancers.