The Monash BDI researchers worked in collaboration with Canadian - based company Kinexus, and used an antibody microarray to simultaneously investigate hundreds of factors involved in cell signalling that were modulated by HCV replication, including
human protein kinases.
This collaborative project between industrial and academic scientists will continue to expand the KCGS with the goal of fully covering
all human protein kinases.
The human protein kinase HIPK2 phosphorylates and downregulates the methyl - binding transcription factor ZBTB4.
Not exact matches
No. 5,817,479, entitled
Human Kinase Homologs, claims 44 ESTs which are fragments of genes encoding
protein kinases.
Cunningham and her postdoc at the time, Christine Kirvan, found that the antibodies literally bind to
human neurons, activating an enzyme called calcium / calmodulin - dependent
protein (CaM)
kinase II.
The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model
human breast cancer cell line and found that it effectively blocked the
protein cyclin - dependent
kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.
There are over 500 known
human kinases and 10s of thousands of possible
proteins they can target.
The sequence similarity between MAD - 3 and pp40 includes a casein
kinase II and consensus tyrosine phosphorylation site, as well as five repeats of a sequence found in the
human erythrocyte
protein ankyrin.
«About 2 percent, or nearly 500, of all
human genes are dedicated to coding
protein kinases and over 50 percent of
kinases are linked to various
human diseases.»
It is no surprise, then, that having faulty
protein kinases may lead to a number of
human conditions, including cardiovascular diseases, cancer and diabetes.
Kim and colleagues are interested in studying the activation mechanism of
protein kinase G I (PKG I) because a mutation of PKG I has been shown to cause thoracic aortic disease, as Kim and his collaborators showed in a previous publication in the American Journal of
Human Genetics.
Rho -
kinase inhibitor Y - 27632 and hypoxia synergistically enhance chondrocytic phenotype and change the S100
protein profile in
human chondrosarcoma cells
This thesis primarily investigates the effects of mechanical cyclic stretching, a 5 % low oxygen atmosphere and the Rho -
kinase inhibitor, Y - 27632, on
protein responses in chondrocytic
human chondrosarcoma (HCS - 2 / 8) cells.
In their latest research, the Joslin team performed many experiments to explore the actions of these two
proteins, called centromere
protein A (CENP - A) and polo - like
kinase - 1 (PLK1), in mice and in cells from
humans and mice.
Molecular interaction and functional regulation of ClC - 3 by Ca2 + / calmodulin - dependent
protein kinase II (CaMKII) in
human malignant glioma.
The
protein kinase B - RAF is mutated in approximately 8 % of
human cancers.
Confocal images of P150 dystrophic retina transplanted with hNPCctx — GDNF and double stained with antibodies against
human nuclear antigen (red) and either (A) recoverin, a photoreceptor and cone bipolar cell marker (green), or (B)
protein kinase Cα (PKCα), a bipolar cell marker (green).
University of Wisconsin A chemical - genetic library of
human cell lines for evaluating pharmacologic inhibition of
protein kinases
Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of
human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G
protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G
protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation,
human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs,
kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G
protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP
protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G
protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G
protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G
protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting
protein kinases as well as
protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G
protein - coupled receptors Richard Neubig, USA (Past Core Member)- G
protein signaling; academic drug discovery Stefan Offermanns, Germany - G
protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G
protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters
Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated
protein kinase; APP, amyloid precursor
protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent
protein kinase kinase β; CHMP2B, charged multivesicular body
protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting
protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding
protein - 1; Epac, exchange
protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated
kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion
kinase family - interacting
protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating
protein; GR, guanidine retinoid; GSK3, glycogen synthase
kinase 3; HD, Huntington's disease; hiPSC,
human induced pluripotent stem cell; hVps, mammalian vacuolar
protein sorting homologue; IKK, inhibitor of nuclear factor κB
kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal
kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat
kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13
protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal
protein S6
kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent
kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 -
kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related
protein kinase; PINK1, PTEN - induced
kinase 1; PKA,
protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding
protein; raptor, regulatory - associated
protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment
protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like
kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane
protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar
protein sorting
Genistein Inhibits Both Estrogen and Growth Factor — stimulated Proliferation of
Human Breast Cancer Cells Cell Growth & Differentiation 1996 (Oct); 7 (10): 1345 — 1351 Genistein is a naturally occurring dietary
protein tyrosine
kinase (PTK) inhibitor that is hypothesized to be responsible for the lower rate of breast cancer observed in Asian women consuming soy.
Itani SI, Ruderman NB, Schmieder F, Boden G. Lipid - Induced Insulin Resistance in
Human Muscle Is Associated With Changes in Diacylglycerol,
Protein Kinase C, and IκB - α.