Sentences with phrase «human schizophrenia and autism»

Feng and colleagues Robert Desimone, director of the McGovern Institute, and MIT professor Feng Zhang, a co-inventor of the CRISPR technology (pending U.S. Patent and Trademark Office investigation and ruling), are working with Chinese researchers to develop CRISPR - modified macaques — a monkey found in many Old World environments — to model human schizophrenia and autism.

Not exact matches

Scientists used CRISPR - Cas9 to shed light on why people with 15q13.3 microdeletion syndrome — a rare human genetic disorder — are more likely to develop brain disorders like autism spectrum disorder, epilepsy and schizophrenia (Karun K. Singh, abstract 103.05, see attached summary).

Further research showed that fetal mice bred to lack these molecules — like animals lacking MHCI, and like humans with autism or schizophrenia — undergo inadequate synaptic pruning in some parts of their brains.

Though these findings have been obtained in mice, the scientists hypothesize that disrupted coordination between the development of the microglia and that of the brain contributes to an increased risk of such neurodevelopmental disorders as autism and schizophrenia in human beings.

With their new method, Zhang and her colleagues hope to soon begin looking at the unique properties of human astrocyte cells in a range of disease types, including Alzheimer's, ALS, stroke, injury, autism, and schizophrenia.

In humans, the cerebellum's extensive connectivity with the rest of the brain suggests it does far more than learn motor skills: it has been shown to have a part in both perception and cognition, with recent work linking cerebellar dysfunction to such complex diseases as schizophrenia and autism.

Still, Dudley feels that evolutionary genetic analysis can help identify the most relevant genes and pathological mechanisms at play in schizophrenia and possibly other mental illnesses that preferentially affect humans — that is, neurodevelopmental disorders related to higher cognition and GABA activity, including autism and attention - deficit / hyperactivity disorder.

«It's been suggested,» Dudley explains, «that the emergence of human speech and language bears a relationship with schizophrenia genetics and, incidentally, autism.»

On the negative side, the researchers found that many of the genes whose activity is unique to modern humans are linked to diseases like Alzheimer's disease, autism and schizophrenia, suggesting that these recent changes in our brain may underlie some of the psychiatric disorders that are so common in humans today.

Now researchers at UC San Francisco have taken the first step toward a comprehensive atlas of gene expression in cells across the developing human brain, making available new insights into how specific cells and gene networks contribute to building this most complex of organs, and serving as a resource for researchers around the world to study the interplay between these genetic programs and neurodevelopmental disorders such as autism, intellectual disability and schizophrenia.

By modeling early development of the human cerebral cortex, researchers hope to better study disorders like autism, epilepsy, and schizophrenia.

He has developed novel cellular models of neurological diseases (schizophrenia, MS, autism, Alzheimer's, Parkinson's) using human induced pluripotent stem cells (iPSCs) derived from donor patients and differentiated to specific neuronal cell types.

This offers interesting opportunities for interpreting mechanisms of genetic contribution to human disease such as schizophrenia, autism, and rheumatoid arthritis.

Dendrite development, the Jans have shown, may hold a key to unraveling nerve regeneration, touch perception, and human mental disorders such as autism and schizophrenia.

We are also interested in the human diseases that affect learning and memory, including Alzheimer's, schizophrenia, bipolar disorder, autism, and ADHD.

These knockouts may be important models for human brain diseases that affect working memory including Alzheimer's Disease, schizophrenia, autism, and ADHD.

Based on their effect on neurons, as well as their locations in the genome, the researchers think that many of the HARs guide genes involved in brain development, as well as psychiatric diseases that are uniquely human, such as autism and schizophrenia.

Integrating human genetic data with proteomic data showed that Arc - PSD95 complexes are enriched in schizophrenia, intellectual disability, autism, and epilepsy mutations and normal variants in intelligence.

A tour of the latest neuroscience of schizophrenia, autism, Alzheimer's disease, ecstatic epilepsy, Cotard's syndrome, out - of - body experiences, and other disorders — revealing the awesome power of the human sense of self from a master of science journalism