«From many candidates, we chose one that is both easily distinguished from
human serum proteins and an unambiguous indicator of the bacteria,» Turko says.
Not exact matches
Larger biomarker signatures can be detected with technology from CDI Laboratories, which offers microarrays of functional
human proteins (over 20,000 on a single array) to test the antibodies present in
human liquid biopsy samples, such as blood,
serum, plasma, CSF, or tissue lysates.
Now, researchers from the Department of Chemistry at Imperial College London have come up with a system that is specific, flexible, and can detect single
protein biomarkers directly in
human serum (a pool of fluid separated from blood).
The researchers found that resistin, an immune
protein commonly found in
human serum, instigates an inappropriate inflammatory response to worm infections, impairing the clearance of the worm.
Based on the observation that obese mice, rats, and
humans all had elevated
serum concentrations of a
protein called GDF15 compared to lean controls, Yumei Xiong and colleagues set out to develop therapies derived from the molecule.
Bone morphogenetic
protein signaling is involved in
human mesenchymal stem cell survival in
serum - free medium.
This
protein binds to murine monoclonal antibodies of defined epitope specificity and HIV - 1 converted
human serum polyclonal antibodies in ELISA and Western
This CFP - 10
protein reacts with
human TB
serum in ELISA and Western ELISA.
This
protein binds to murine monoclonal antibodies of defined epitope specificity and
human serum polyclonal antibodies in ELISA and Western ELISA.
Lack of cross-reactivity between the Bacillus thuringiensis derived
protein Cry1F in maize grain and dust mite Der p 7
protein with
human sera positive for Der p 7 - IgE.
Immunoblot analysis using mouse monoclonal antibody to
human IgM detected IgM to cytomegalovirus (CMV)- specific
proteins (150, 42, 38, 32, and 28 kDa) in 74 (38 %) of 197 seropositive
serum samples from 197 individuals in three subject groups: 43 surgical patients, 31 patients with solid tumors, and 123 healthy individuals.
Dr. Herta Spencer, of the Veterans Administration Hospital in Hines, Illinois, explains that the animal and
human studies that correlated calcium loss with high
protein diets used isolated, fractionated amino acids from milk or eggs.19 Her studies show that when
protein is given as meat, subjects do not show any increase in calcium excreted, or any significant change in
serum calcium, even over a long period.20 Other investigators found that a high -
protein intake increased calcium absorption when dietary calcium was adequate or high, but not when calcium intake was a low 500 mg per day.21
In
humans, unlike rodents, severe calorie restriction does not reduce
serum iGF - 1 concentration unless
protein intake is also reduced.
Excessive
protein intake represents a useless metabolic load to the infant, but if the
protein amount is reduced in infant formulas more toward the standard value of
human milk, this causes a reduction in the tryptophan and taurine concentrations in the
serum of formula - fed infants, even when they contain excess whey
protein.
One measured fluid, electrolyte, and renal indices of hydration over eleven days of caffeine consumption in
human subjects, finding that doses of up to 6 mg caffeine per kilogram of body weight had no effect on body mass, urine osmolality (urine concentration), urine specific gravity (concentration of excreted materials in urine), urine color, urine volume, sodium excretion, potassium secretion, creatinine content, blood urea nitrogen (forms when
protein breaks down), and
serum levels of sodium and potassium.