Xu and his team, which includes researchers from Penn's departments of Dermatology and Biology, as well as the New Jersey Institute of Technology, started with
human skin cells called dermal fibroblasts.
Not exact matches
We referred to the news that these
cells,
called induced pluripotent stem
cells (iPSCs), could be made from
human skin....
For the new study, the team used a
cell - reprogramming technique (similar to those used to reprogram
skin cells into stem
cells) to generate
human DRG - type sensory neurons from ordinary
skin cells called fibroblasts.
Researchers at the Fund for the Replacement of Animals in Medical Experiments (FRAME) in Nottingham, have just finished the first stage of development, which draws on research showing that
human skin cells produce chemicals
called cytokines when exposed to chemicals that are irritants.
The ability of scientists to convert
human skin cells into other
cell types, such as neurons, has the potential to enhance understanding of disease and lead to finding new ways to heal damaged tissues and organs, a field
called regenerative medicine.
«We used
human skin cells that we obtained from patients affected with ALS and converted them into neurons via a technology
called induced pluripotent stem
cell production,» she explains.
Using a process
called cellular reprogramming, the researchers take a patient's
skin cells, convert them into so -
called induced pluripotent stem (iPS)
cells, which can differentiate into all the
cells within the
human body.
Instead, they simply exposed
human skin cells to four natural gene switches,
called transcription factors.
In findings appearing online today in
Cell Stem
Cell, researchers in the laboratory of Gladstone Investigator Yadong Huang, MD, PhD, describe how they transferred a single gene
called Sox2 into both mouse and
human skin cells.